YBR207W / FTH1

Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR207W / FTH1

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:2.96|P-value:1.50E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.03|P-value:1.28E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.37|P-value:2.41E-5 ID:SGTC_442|Compound:cape|FD-Score:2.92|P-value:1.82E-4 ID:SGTC_462|Compound:ag-879|FD-Score:2.59|P-value:7.66E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.24|P-value:4.82E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:2.54|P-value:9.48E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.76|P-value:4.44E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:2.72|P-value:4.38E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.47|P-value:1.14E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:2.64|P-value:6.05E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:2.66|P-value:5.71E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:2.53|P-value:9.57E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.02|P-value:1.12E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.26|P-value:1.03E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.90|P-value:1.27E-6 ID:SGTC_1270|Compound:0831-1170|FD-Score:4.20|P-value:1.46E-7 ID:SGTC_1271|Compound:0832-2808|FD-Score:2.76|P-value:3.60E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-3.20|P-value:5.75E-5 ID:SGTC_1947|Compound:st076332|FD-Score:-3.37|P-value:2.47E-5 ID:SGTC_1988|Compound:st071872|FD-Score:3.01|P-value:1.18E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.79|P-value:1.88E-6 ID:SGTC_2107|Compound:5363541|FD-Score:4.26|P-value:9.93E-8 ID:SGTC_2121|Compound:5257820|FD-Score:2.91|P-value:1.89E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.52|P-value:8.73E-6 ID:SGTC_2150|Compound:5556613|FD-Score:3.10|P-value:7.73E-5 ID:SGTC_2158|Compound:5657123|FD-Score:2.59|P-value:7.61E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-2.95|P-value:1.89E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.60|P-value:5.50E-6 ID:SGTC_2415|Compound:st077333|FD-Score:4.60|P-value:1.00E-8 ID:SGTC_2450|Compound:5739737|FD-Score:-2.58|P-value:9.37E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:4.38|P-value:4.53E-8 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.00|P-value:1.24E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.81|P-value:1.65E-6 ID:SGTC_2693|Compound:st077581|FD-Score:4.39|P-value:4.37E-8 ID:SGTC_2788|Compound:5282734|FD-Score:2.92|P-value:1.78E-4 ID:SGTC_2839|Compound:9003951|FD-Score:2.98|P-value:1.37E-4 ID:SGTC_2891|Compound:9063876|FD-Score:2.58|P-value:7.92E-4 ID:SGTC_2898|Compound:9056270|FD-Score:3.41|P-value:1.57E-5 ID:SGTC_2961|Compound:9083290|FD-Score:-3.31|P-value:3.37E-5 ID:SGTC_2962|Compound:9082311|FD-Score:-3.00|P-value:1.53E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:2.96|P-value:1.50E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.03|P-value:1.28E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.37|P-value:2.41E-5 ID:SGTC_442|Compound:cape|FD-Score:2.92|P-value:1.82E-4 ID:SGTC_462|Compound:ag-879|FD-Score:2.59|P-value:7.66E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.24|P-value:4.82E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:2.54|P-value:9.48E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.76|P-value:4.44E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:2.72|P-value:4.38E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.47|P-value:1.14E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:2.64|P-value:6.05E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:2.66|P-value:5.71E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:2.53|P-value:9.57E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.02|P-value:1.12E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.26|P-value:1.03E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.90|P-value:1.27E-6 ID:SGTC_1270|Compound:0831-1170|FD-Score:4.20|P-value:1.46E-7 ID:SGTC_1271|Compound:0832-2808|FD-Score:2.76|P-value:3.60E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-3.20|P-value:5.75E-5 ID:SGTC_1947|Compound:st076332|FD-Score:-3.37|P-value:2.47E-5 ID:SGTC_1988|Compound:st071872|FD-Score:3.01|P-value:1.18E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.79|P-value:1.88E-6 ID:SGTC_2107|Compound:5363541|FD-Score:4.26|P-value:9.93E-8 ID:SGTC_2121|Compound:5257820|FD-Score:2.91|P-value:1.89E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.52|P-value:8.73E-6 ID:SGTC_2150|Compound:5556613|FD-Score:3.10|P-value:7.73E-5 ID:SGTC_2158|Compound:5657123|FD-Score:2.59|P-value:7.61E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-2.95|P-value:1.89E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.60|P-value:5.50E-6 ID:SGTC_2415|Compound:st077333|FD-Score:4.60|P-value:1.00E-8 ID:SGTC_2450|Compound:5739737|FD-Score:-2.58|P-value:9.37E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:4.38|P-value:4.53E-8 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.00|P-value:1.24E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.81|P-value:1.65E-6 ID:SGTC_2693|Compound:st077581|FD-Score:4.39|P-value:4.37E-8 ID:SGTC_2788|Compound:5282734|FD-Score:2.92|P-value:1.78E-4 ID:SGTC_2839|Compound:9003951|FD-Score:2.98|P-value:1.37E-4 ID:SGTC_2891|Compound:9063876|FD-Score:2.58|P-value:7.92E-4 ID:SGTC_2898|Compound:9056270|FD-Score:3.41|P-value:1.57E-5 ID:SGTC_2961|Compound:9083290|FD-Score:-3.31|P-value:3.37E-5 ID:SGTC_2962|Compound:9082311|FD-Score:-3.00|P-value:1.53E-4

Top fitness defect scores for YBR207W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2415 st077333 4.60 57.7 µM 1.00E-8 28 2.10E-6
2 SGTC_2693 st077581 4.39 40.7 µM 4.37E-8 23 5.74E-6
3 SGTC_2605 digitonin 4.38 300.0 nM 4.53E-8 16 5.89E-6
4 SGTC_2107 5363541 4.26 170.2 µM 9.93E-8 6 1.01E-5
5 SGTC_996 3970-0799 4.26 1.8 µM 1.03E-7 72 1.03E-5
6 SGTC_1270 0831-1170 4.20 17.3 µM 1.46E-7 9 1.31E-5
7 SGTC_2616 abietic acid 3.81 100.0 µM 1.65E-6 35 6.94E-5
8 SGTC_2103 5378138 3.79 10.0 µM 1.88E-6 20 7.58E-5
9 SGTC_2316 5844804 3.60 197.4 µM 5.50E-6 46 1.59E-4
10 SGTC_2130 NSC 7 3.52 2.5 µM 8.73E-6 copper-dependent oxidative stress 48 2.18E-4
11 SGTC_669 0108-0021 3.47 26.2 µM 1.14E-5 fatty acid desaturase (OLE1) 114 2.62E-4
12 SGTC_2898 9056270 3.41 58.4 µM 1.57E-5 9 3.27E-4
13 SGTC_2150 5556613 3.10 200.0 µM 7.73E-5 48 9.83E-4
14 SGTC_882 0843-0131 3.02 351.0 µM 1.12E-4 51 0.00127
15 SGTC_1988 st071872 3.01 53.4 µM 1.18E-4 42 0.00131
16 SGTC_2608 thymoquinone 3.00 42.7 µM 1.24E-4 55 0.00136
17 SGTC_2839 9003951 2.98 26.0 µM 1.37E-4 50 0.00146
18 SGTC_39 0986-0283 2.96 58.4 µM 1.50E-4 calcium & mitochondrial duress 89 0.00155
19 SGTC_2788 5282734 2.92 71.4 µM 1.78E-4 116 0.00175
20 SGTC_442 cape 2.92 100.0 µM 1.82E-4 43 0.00178

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.338 2.82E-90 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.312 1.03E-76 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.294 9.08E-68 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.291 1.79E-66 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.288 5.76E-65 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.285 1.07E-63 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.281 6.41E-62 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.279 6.81E-61 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.267 7.81E-56 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.252 8.42E-50 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.250 7.64E-49 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.249 1.74E-48 YDL171C GLT1 hom NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
0.246 2.71E-47 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.244 8.27E-47 YPR010C RPA135 het RNA polymerase I second largest subunit A135
0.238 1.49E-44 YDR339C FCF1 het Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p