YBR210W / ERV15

Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR210W / ERV15

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:2.94|P-value:7.51E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.20|P-value:2.77E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.52|P-value:7.34E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:3.29|P-value:1.93E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:-3.46|P-value:1.09E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.16|P-value:3.25E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:-3.68|P-value:4.10E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.37|P-value:1.55E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.17|P-value:3.14E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.01|P-value:5.93E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.27|P-value:2.14E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.27|P-value:2.10E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.10|P-value:4.21E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.52|P-value:8.18E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:2.96|P-value:7.02E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.02|P-value:5.65E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.45|P-value:9.90E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.33|P-value:1.65E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.68|P-value:3.69E-5 ID:SGTC_1603|Compound:st002045|FD-Score:-3.15|P-value:3.71E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-3.02|P-value:6.27E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-3.04|P-value:5.82E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-3.21|P-value:3.02E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-4.46|P-value:8.83E-7 ID:SGTC_2287|Compound:7945887|FD-Score:-3.77|P-value:2.74E-5 ID:SGTC_2451|Compound:5856223|FD-Score:5.07|P-value:2.43E-8 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.09|P-value:4.67E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-4.24|P-value:2.84E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-2.94|P-value:8.23E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.63|P-value:5.18E-5 ID:SGTC_2888|Compound:9058547|FD-Score:3.54|P-value:6.81E-5 ID:SGTC_2942|Compound:9052777|FD-Score:-3.29|P-value:2.20E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-5.36|P-value:4.62E-9 ID:SGTC_2948|Compound:9070189|FD-Score:-2.94|P-value:8.26E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.58|P-value:6.37E-5 ID:SGTC_2952|Compound:9073731|FD-Score:-3.03|P-value:5.95E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.68|P-value:3.58E-5 ID:SGTC_3056|Compound:9094900|FD-Score:3.54|P-value:6.78E-5 ID:SGTC_3|Compound:0833-0587|FD-Score:2.94|P-value:7.51E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.20|P-value:2.77E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.52|P-value:7.34E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:3.29|P-value:1.93E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:-3.46|P-value:1.09E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.16|P-value:3.25E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:-3.68|P-value:4.10E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.37|P-value:1.55E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.17|P-value:3.14E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.01|P-value:5.93E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.27|P-value:2.14E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.27|P-value:2.10E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.10|P-value:4.21E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.52|P-value:8.18E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:2.96|P-value:7.02E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.02|P-value:5.65E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.45|P-value:9.90E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.33|P-value:1.65E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.68|P-value:3.69E-5 ID:SGTC_1603|Compound:st002045|FD-Score:-3.15|P-value:3.71E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-3.02|P-value:6.27E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-3.04|P-value:5.82E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-3.21|P-value:3.02E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-4.46|P-value:8.83E-7 ID:SGTC_2287|Compound:7945887|FD-Score:-3.77|P-value:2.74E-5 ID:SGTC_2451|Compound:5856223|FD-Score:5.07|P-value:2.43E-8 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.09|P-value:4.67E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-4.24|P-value:2.84E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-2.94|P-value:8.23E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.63|P-value:5.18E-5 ID:SGTC_2888|Compound:9058547|FD-Score:3.54|P-value:6.81E-5 ID:SGTC_2942|Compound:9052777|FD-Score:-3.29|P-value:2.20E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-5.36|P-value:4.62E-9 ID:SGTC_2948|Compound:9070189|FD-Score:-2.94|P-value:8.26E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.58|P-value:6.37E-5 ID:SGTC_2952|Compound:9073731|FD-Score:-3.03|P-value:5.95E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.68|P-value:3.58E-5 ID:SGTC_3056|Compound:9094900|FD-Score:3.54|P-value:6.78E-5

Top fitness defect scores for YBR210W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2451 5856223 5.07 45.7 µM 2.43E-8 6 2.01E-7
2 SGTC_3028 9087778 3.68 49.5 µM 3.58E-5 20 1.15E-4
3 SGTC_1418 3966-3099 3.68 2.4 µM 3.69E-5 29 1.17E-4
4 SGTC_3056 9094900 3.54 49.5 µM 6.78E-5 37 2.00E-4
5 SGTC_2888 9058547 3.54 13.0 µM 6.81E-5 12 2.00E-4
6 SGTC_361 000s-0510 3.52 1.4 µM 7.34E-5 47 2.14E-4
7 SGTC_1338 1486-1223 3.45 76.0 µM 9.90E-5 37 2.78E-4
8 SGTC_1370 2001-0092 3.33 44.6 µM 1.65E-4 64 4.32E-4
9 SGTC_605 1315-0399 3.29 119.0 µM 1.93E-4 Golgi 53 4.97E-4
10 SGTC_1098 clofazimine 3.27 15.1 µM 2.10E-4 heme biosynthesis & mitochondrial translocase 59 5.35E-4
11 SGTC_1043 0916-0009 3.27 19.3 µM 2.14E-4 49 5.44E-4
12 SGTC_121 0557-0495 3.20 61.3 µM 2.77E-4 calcium & mitochondrial duress 109 6.80E-4
13 SGTC_937 3122-0005 3.17 46.7 µM 3.14E-4 53 7.59E-4
14 SGTC_624 k048-0052 3.16 28.0 µM 3.25E-4 Golgi 41 7.82E-4
15 SGTC_1115 galangin 3.10 695.7 nM 4.21E-4 RPP1 & pyrimidine depletion 47 9.81E-4
16 SGTC_1334 1486-0610 3.02 236.0 µM 5.65E-4 60S ribosome export 56 0.00127
17 SGTC_956 1185-0240 3.01 191.0 µM 5.93E-4 67 0.00132
18 SGTC_1205 4161-2785 2.96 76.0 µM 7.02E-4 71 0.00153
19 SGTC_3 0833-0587 2.94 95.6 µM 7.51E-4 redox potentiating 62 0.00163
20 SGTC_967 1306-0166 2.84 352.0 µM 0.00108 90 0.00223

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.37E-12 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.107 5.82E-10 YLR120C YPS1 hom Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.106 6.42E-10 YLL028W TPO1 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
0.103 2.39E-9 YML101C CUE4 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication
0.093 6.52E-8 YKL071W_p YKL071W_p hom Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.089 2.74E-7 YER085C_p YER085C_p hom Putative protein of unknown function
0.087 4.19E-7 YLR368W MDM30 hom F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains
0.085 7.46E-7 YDR487C RIB3 het 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration
0.084 9.98E-7 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.084 1.13E-6 YPL138C SPP1 hom Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein
0.082 2.22E-6 YMR318C ADH6 hom NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress
0.079 5.04E-6 YGL110C CUE3 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
0.078 5.44E-6 YEL034W HYP2 het Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.077 7.65E-6 YMR105C PGM2 hom Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress
0.076 1.10E-5 YDR496C PUF6 hom Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis