YBR225W_p

Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR225W / YBR225W

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:3.25|P-value:2.97E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.84|P-value:3.30E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.67|P-value:7.03E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.12|P-value:5.97E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.13|P-value:6.50E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:3.23|P-value:3.15E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.13|P-value:4.71E-4 ID:SGTC_719|Compound:2810-4230|FD-Score:-3.35|P-value:2.59E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.81|P-value:2.82E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.16|P-value:5.19E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:-3.04|P-value:8.01E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:-3.37|P-value:2.38E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:4.30|P-value:2.87E-6 ID:SGTC_1115|Compound:galangin|FD-Score:3.92|P-value:1.72E-5 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.29|P-value:2.49E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.73|P-value:4.13E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.66|P-value:5.49E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:6.91|P-value:1.75E-13 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.10|P-value:5.22E-4 ID:SGTC_1571|Compound:st070080|FD-Score:-3.14|P-value:5.58E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.66|P-value:5.42E-5 ID:SGTC_1684|Compound:st024538|FD-Score:-3.26|P-value:3.55E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.01|P-value:7.25E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.09|P-value:5.31E-4 ID:SGTC_1797|Compound:st048695|FD-Score:3.04|P-value:6.37E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.04|P-value:8.01E-4 ID:SGTC_2246|Compound:7293507|FD-Score:4.09|P-value:7.96E-6 ID:SGTC_2362|Compound:9071156|FD-Score:3.15|P-value:4.31E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.52|P-value:9.83E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.02|P-value:1.11E-5 ID:SGTC_2815|Compound:7968870|FD-Score:3.67|P-value:5.39E-5 ID:SGTC_2850|Compound:9015429|FD-Score:-3.21|P-value:4.34E-4 ID:SGTC_2859|Compound:9028643|FD-Score:3.40|P-value:1.65E-4 ID:SGTC_2932|Compound:9016711|FD-Score:2.98|P-value:8.11E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.31|P-value:2.36E-4 ID:SGTC_3343|Compound:9148379|FD-Score:3.62|P-value:6.67E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:3.25|P-value:2.97E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.84|P-value:3.30E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.67|P-value:7.03E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.12|P-value:5.97E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.13|P-value:6.50E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:3.23|P-value:3.15E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.13|P-value:4.71E-4 ID:SGTC_719|Compound:2810-4230|FD-Score:-3.35|P-value:2.59E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.81|P-value:2.82E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.16|P-value:5.19E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:-3.04|P-value:8.01E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:-3.37|P-value:2.38E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:4.30|P-value:2.87E-6 ID:SGTC_1115|Compound:galangin|FD-Score:3.92|P-value:1.72E-5 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.29|P-value:2.49E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.73|P-value:4.13E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.66|P-value:5.49E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:6.91|P-value:1.75E-13 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.10|P-value:5.22E-4 ID:SGTC_1571|Compound:st070080|FD-Score:-3.14|P-value:5.58E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.66|P-value:5.42E-5 ID:SGTC_1684|Compound:st024538|FD-Score:-3.26|P-value:3.55E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.01|P-value:7.25E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.09|P-value:5.31E-4 ID:SGTC_1797|Compound:st048695|FD-Score:3.04|P-value:6.37E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.04|P-value:8.01E-4 ID:SGTC_2246|Compound:7293507|FD-Score:4.09|P-value:7.96E-6 ID:SGTC_2362|Compound:9071156|FD-Score:3.15|P-value:4.31E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.52|P-value:9.83E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.02|P-value:1.11E-5 ID:SGTC_2815|Compound:7968870|FD-Score:3.67|P-value:5.39E-5 ID:SGTC_2850|Compound:9015429|FD-Score:-3.21|P-value:4.34E-4 ID:SGTC_2859|Compound:9028643|FD-Score:3.40|P-value:1.65E-4 ID:SGTC_2932|Compound:9016711|FD-Score:2.98|P-value:8.11E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.31|P-value:2.36E-4 ID:SGTC_3343|Compound:9148379|FD-Score:3.62|P-value:6.67E-5

Top fitness defect scores for YBR225W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1457 k015-0032 6.91 57.3 µM 1.75E-13 3 2.38E-12
2 SGTC_958 1222-0007 4.30 33.0 µM 2.87E-6 22 8.59E-6
3 SGTC_435 c-PAF 4.13 6.7 µM 6.50E-6 36 1.81E-5
4 SGTC_2246 7293507 4.09 91.6 µM 7.96E-6 26 2.17E-5
5 SGTC_2582 agaric acid 4.02 100.0 µM 1.11E-5 redox potentiating 309 2.94E-5
6 SGTC_1115 galangin 3.92 695.7 nM 1.72E-5 RPP1 & pyrimidine depletion 15 4.38E-5
7 SGTC_817 1391-0715 3.81 46.0 µM 2.82E-5 21 6.85E-5
8 SGTC_1259 0671-0132 3.73 43.0 µM 4.13E-5 30 9.69E-5
9 SGTC_2815 7968870 3.67 71.4 µM 5.39E-5 31 1.23E-4
10 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 3.66 67.5 µM 5.42E-5 57 1.24E-4
11 SGTC_1261 0712-0010 3.66 12.7 µM 5.49E-5 RNA processing & uracil transport 31 1.26E-4
12 SGTC_3343 9148379 3.62 19.0 µM 6.67E-5 9 1.50E-4
13 SGTC_2363 9053361 3.52 176.0 µM 9.83E-5 Golgi 48 2.13E-4
14 SGTC_2859 9028643 3.40 45.5 µM 1.65E-4 29 3.42E-4
15 SGTC_3210 9128157 3.31 49.5 µM 2.36E-4 79 4.73E-4
16 SGTC_1138 3761-0006 3.29 1.0 µM 2.49E-4 21 4.96E-4
17 SGTC_39 0986-0283 3.25 58.4 µM 2.97E-4 calcium & mitochondrial duress 65 5.83E-4
18 SGTC_568 1193-0097 3.23 7.5 µM 3.15E-4 ERAD & cell cycle 198 6.15E-4
19 SGTC_2362 9071156 3.15 126.0 µM 4.31E-4 34 8.18E-4
20 SGTC_716 1683-5115 3.13 658.0 µM 4.71E-4 53 8.86E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.203 2.09E-32 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.158 3.93E-20 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.155 1.48E-19 YJL049W_p YJL049W_p hom Putative protein of unknown function; YJL049W is a non-essential gene
0.149 3.56E-18 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.136 2.91E-15 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.134 5.59E-15 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.131 2.87E-14 YOR010C TIR2 hom Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
0.128 9.97E-14 YIL111W COX5B hom Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
0.124 6.79E-13 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.122 1.55E-12 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.118 8.28E-12 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.108 3.99E-10 YFR029W PTR3 het Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
0.102 2.80E-9 YBR082C UBC4 hom Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication
0.102 3.15E-9 YJL043W_p YJL043W_p hom Putative protein of unknown function; YJL043W is a non-essential gene
0.102 3.56E-9 YJL157C FAR1 hom Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress