YBR239C_p / ERT1

Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR239C / ERT1

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.27|P-value:2.25E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.11|P-value:4.21E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.53|P-value:7.56E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:4.22|P-value:2.81E-6 ID:SGTC_321|Compound:4534-3890|FD-Score:4.04|P-value:6.85E-6 ID:SGTC_469|Compound:w7|FD-Score:-2.92|P-value:6.61E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:2.94|P-value:8.16E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:-2.86|P-value:8.16E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.73|P-value:3.07E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:2.94|P-value:8.16E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:-2.95|P-value:5.86E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:2.95|P-value:7.76E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.50|P-value:8.50E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:2.90|P-value:9.41E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-4.48|P-value:4.68E-7 ID:SGTC_1251|Compound:0490-5699|FD-Score:-2.91|P-value:6.70E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.17|P-value:3.34E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.17|P-value:3.40E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.48|P-value:9.22E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.71|P-value:1.26E-7 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.44|P-value:1.09E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-3.64|P-value:3.23E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.81|P-value:2.11E-5 ID:SGTC_2165|Compound:5727197|FD-Score:3.14|P-value:3.78E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.27|P-value:1.63E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.71|P-value:2.38E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.38|P-value:8.08E-7 ID:SGTC_2478|Compound:5763493|FD-Score:-3.61|P-value:3.77E-5 ID:SGTC_2483|Compound:5729050|FD-Score:4.07|P-value:6.15E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:4.34|P-value:1.47E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.19|P-value:3.10E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.36|P-value:1.52E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.22|P-value:2.74E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-3.10|P-value:3.29E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-3.15|P-value:2.63E-4 ID:SGTC_3161|Compound:9100388|FD-Score:3.75|P-value:2.78E-5 ID:SGTC_3206|Compound:9114350|FD-Score:2.94|P-value:8.17E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.66|P-value:2.89E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-2.88|P-value:7.51E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.20|P-value:2.96E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-4.49|P-value:4.34E-7 ID:SGTC_65|Compound:0798-0905|FD-Score:3.27|P-value:2.25E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.11|P-value:4.21E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.53|P-value:7.56E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:4.22|P-value:2.81E-6 ID:SGTC_321|Compound:4534-3890|FD-Score:4.04|P-value:6.85E-6 ID:SGTC_469|Compound:w7|FD-Score:-2.92|P-value:6.61E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:2.94|P-value:8.16E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:-2.86|P-value:8.16E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.73|P-value:3.07E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:2.94|P-value:8.16E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:-2.95|P-value:5.86E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:2.95|P-value:7.76E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.50|P-value:8.50E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:2.90|P-value:9.41E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-4.48|P-value:4.68E-7 ID:SGTC_1251|Compound:0490-5699|FD-Score:-2.91|P-value:6.70E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.17|P-value:3.34E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.17|P-value:3.40E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.48|P-value:9.22E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.71|P-value:1.26E-7 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.44|P-value:1.09E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-3.64|P-value:3.23E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.81|P-value:2.11E-5 ID:SGTC_2165|Compound:5727197|FD-Score:3.14|P-value:3.78E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.27|P-value:1.63E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.71|P-value:2.38E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.38|P-value:8.08E-7 ID:SGTC_2478|Compound:5763493|FD-Score:-3.61|P-value:3.77E-5 ID:SGTC_2483|Compound:5729050|FD-Score:4.07|P-value:6.15E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:4.34|P-value:1.47E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.19|P-value:3.10E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.36|P-value:1.52E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.22|P-value:2.74E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-3.10|P-value:3.29E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-3.15|P-value:2.63E-4 ID:SGTC_3161|Compound:9100388|FD-Score:3.75|P-value:2.78E-5 ID:SGTC_3206|Compound:9114350|FD-Score:2.94|P-value:8.17E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.66|P-value:2.89E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-2.88|P-value:7.51E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.20|P-value:2.96E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-4.49|P-value:4.34E-7

Top fitness defect scores for YBR239C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2563 tomatine 4.34 8.5 µM 1.47E-6 29 6.98E-6
2 SGTC_213 1246-0773 4.22 967.0 nM 2.81E-6 16 1.22E-5
3 SGTC_2483 5729050 4.07 27.2 µM 6.15E-6 21 2.40E-5
4 SGTC_321 4534-3890 4.04 65.3 µM 6.85E-6 RPP1 & pyrimidine depletion 2 2.63E-5
5 SGTC_2056 5235370 3.81 200.0 µM 2.11E-5 45 6.94E-5
6 SGTC_3161 9100388 3.75 49.5 µM 2.78E-5 iron homeostasis 10 8.80E-5
7 SGTC_753 1322-0200 3.73 289.0 µM 3.07E-5 29 9.61E-5
8 SGTC_102 gallobenzophenone 3.53 83.6 µM 7.56E-5 redox potentiating 55 2.09E-4
9 SGTC_1181 1222-0449 3.50 220.0 µM 8.50E-5 37 2.31E-4
10 SGTC_1350 1495-0454 3.48 146.0 µM 9.22E-5 49 2.48E-4
11 SGTC_1698 5-fluorocytosine 3.44 1.1 µM 1.09E-4 exosome 17 2.86E-4
12 SGTC_2713 st079149 3.36 53.4 µM 1.52E-4 40 3.83E-4
13 SGTC_65 0798-0905 3.27 35.0 µM 2.25E-4 calcium & mitochondrial duress 135 5.37E-4
14 SGTC_3085 9117376 3.22 49.5 µM 2.74E-4 30 6.38E-4
15 SGTC_3309 9129340 3.20 25.8 µM 2.96E-4 43 6.81E-4
16 SGTC_2614 arthonioic acid 3.19 13.4 µM 3.10E-4 47 7.09E-4
17 SGTC_1293 1000-1278 3.17 195.0 µM 3.34E-4 42 7.56E-4
18 SGTC_1343 1487-0095 3.17 224.0 µM 3.40E-4 28 7.68E-4
19 SGTC_2165 5727197 3.14 32.1 µM 3.78E-4 74 8.42E-4
20 SGTC_81 0411-0046 3.11 10.0 µM 4.21E-4 47 9.25E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.222 1.16E-38 YNL253W TEX1 hom Protein involved in mRNA export, component of the transcription export (TREX) complex
0.172 1.52E-23 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.147 9.88E-18 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.144 7.01E-17 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.138 9.76E-16 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.136 2.33E-15 YLR285W NNT1 hom S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination
0.135 3.45E-15 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.135 4.89E-15 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.127 1.32E-13 YJR099W YUH1 hom Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
0.123 8.71E-13 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.121 2.12E-12 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.118 7.48E-12 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.117 1.21E-11 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.116 1.49E-11 YDR189W SLY1 het Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
0.114 3.75E-11 YDL187C_d YDL187C_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data