YBR241C_p

Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR241C / YBR241C

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:3.24|P-value:2.18E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:2.81|P-value:1.96E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:2.50|P-value:8.21E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:-2.62|P-value:5.37E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-2.55|P-value:7.03E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:2.73|P-value:2.84E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-2.73|P-value:3.13E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:2.60|P-value:5.11E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.10|P-value:5.40E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:-2.50|P-value:9.00E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:4.51|P-value:6.95E-9 ID:SGTC_666|Compound:0272-0154|FD-Score:-2.77|P-value:2.72E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:2.71|P-value:3.20E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:-2.74|P-value:3.05E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.31|P-value:1.55E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:2.91|P-value:1.21E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.92|P-value:4.00E-7 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.27|P-value:2.19E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:2.78|P-value:2.30E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:2.49|P-value:8.27E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:2.75|P-value:2.66E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.88|P-value:6.03E-7 ID:SGTC_1527|Compound:coumarin|FD-Score:3.29|P-value:1.75E-5 ID:SGTC_1642|Compound:st009582|FD-Score:2.98|P-value:8.52E-5 ID:SGTC_1683|Compound:st010134|FD-Score:-2.49|P-value:9.29E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.02|P-value:7.19E-5 ID:SGTC_1947|Compound:st076332|FD-Score:-2.82|P-value:2.11E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.35|P-value:1.23E-5 ID:SGTC_1977|Compound:st070720|FD-Score:3.47|P-value:6.26E-6 ID:SGTC_1984|Compound:st072354|FD-Score:-2.92|P-value:1.31E-4 ID:SGTC_1998|Compound:st075797|FD-Score:2.51|P-value:7.80E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-2.85|P-value:1.86E-4 ID:SGTC_2148|Compound:5546263|FD-Score:2.49|P-value:8.37E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.03|P-value:7.47E-5 ID:SGTC_2295|Compound:7971645|FD-Score:2.57|P-value:6.04E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-2.85|P-value:1.82E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-2.50|P-value:8.93E-4 ID:SGTC_2402|Compound:5553605|FD-Score:2.64|P-value:4.45E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.13|P-value:4.06E-5 ID:SGTC_2487|Compound:5918373|FD-Score:2.78|P-value:2.26E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:2.91|P-value:1.22E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.47|P-value:1.05E-8 ID:SGTC_2625|Compound:euphol|FD-Score:2.90|P-value:1.28E-4 ID:SGTC_2812|Compound:7970281|FD-Score:2.48|P-value:8.74E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-2.70|P-value:3.72E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-3.94|P-value:4.06E-7 ID:SGTC_2982|Compound:9019404|FD-Score:-3.83|P-value:8.06E-7 ID:SGTC_3020|Compound:9089140|FD-Score:3.19|P-value:2.85E-5 ID:SGTC_3024|Compound:9090631|FD-Score:3.18|P-value:3.03E-5 ID:SGTC_3031|Compound:9088762|FD-Score:-3.24|P-value:2.47E-5 ID:SGTC_3170|Compound:9103054|FD-Score:-2.61|P-value:5.51E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.18|P-value:3.06E-5 ID:SGTC_3306|Compound:9127676|FD-Score:-2.50|P-value:8.83E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.24|P-value:2.18E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:2.81|P-value:1.96E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:2.50|P-value:8.21E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:-2.62|P-value:5.37E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-2.55|P-value:7.03E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:2.73|P-value:2.84E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-2.73|P-value:3.13E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:2.60|P-value:5.11E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.10|P-value:5.40E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:-2.50|P-value:9.00E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:4.51|P-value:6.95E-9 ID:SGTC_666|Compound:0272-0154|FD-Score:-2.77|P-value:2.72E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:2.71|P-value:3.20E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:-2.74|P-value:3.05E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.31|P-value:1.55E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:2.91|P-value:1.21E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.92|P-value:4.00E-7 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.27|P-value:2.19E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:2.78|P-value:2.30E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:2.49|P-value:8.27E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:2.75|P-value:2.66E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.88|P-value:6.03E-7 ID:SGTC_1527|Compound:coumarin|FD-Score:3.29|P-value:1.75E-5 ID:SGTC_1642|Compound:st009582|FD-Score:2.98|P-value:8.52E-5 ID:SGTC_1683|Compound:st010134|FD-Score:-2.49|P-value:9.29E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.02|P-value:7.19E-5 ID:SGTC_1947|Compound:st076332|FD-Score:-2.82|P-value:2.11E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.35|P-value:1.23E-5 ID:SGTC_1977|Compound:st070720|FD-Score:3.47|P-value:6.26E-6 ID:SGTC_1984|Compound:st072354|FD-Score:-2.92|P-value:1.31E-4 ID:SGTC_1998|Compound:st075797|FD-Score:2.51|P-value:7.80E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-2.85|P-value:1.86E-4 ID:SGTC_2148|Compound:5546263|FD-Score:2.49|P-value:8.37E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.03|P-value:7.47E-5 ID:SGTC_2295|Compound:7971645|FD-Score:2.57|P-value:6.04E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-2.85|P-value:1.82E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-2.50|P-value:8.93E-4 ID:SGTC_2402|Compound:5553605|FD-Score:2.64|P-value:4.45E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.13|P-value:4.06E-5 ID:SGTC_2487|Compound:5918373|FD-Score:2.78|P-value:2.26E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:2.91|P-value:1.22E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.47|P-value:1.05E-8 ID:SGTC_2625|Compound:euphol|FD-Score:2.90|P-value:1.28E-4 ID:SGTC_2812|Compound:7970281|FD-Score:2.48|P-value:8.74E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-2.70|P-value:3.72E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-3.94|P-value:4.06E-7 ID:SGTC_2982|Compound:9019404|FD-Score:-3.83|P-value:8.06E-7 ID:SGTC_3020|Compound:9089140|FD-Score:3.19|P-value:2.85E-5 ID:SGTC_3024|Compound:9090631|FD-Score:3.18|P-value:3.03E-5 ID:SGTC_3031|Compound:9088762|FD-Score:-3.24|P-value:2.47E-5 ID:SGTC_3170|Compound:9103054|FD-Score:-2.61|P-value:5.51E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.18|P-value:3.06E-5 ID:SGTC_3306|Compound:9127676|FD-Score:-2.50|P-value:8.83E-4

Top fitness defect scores for YBR241C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_662 k832-1615 4.51 104.0 µM 6.95E-9 10 3.26E-6
2 SGTC_1039 k821-0043 3.92 94.0 µM 4.00E-7 Golgi 24 4.43E-5
3 SGTC_1977 st070720 3.47 65.3 µM 6.26E-6 19 2.62E-4
4 SGTC_1955 wogonin 3.35 32.4 µM 1.23E-5 28 4.05E-4
5 SGTC_773 4358-1457 3.31 44.6 µM 1.55E-5 61 4.72E-4
6 SGTC_1527 coumarin 3.29 137.0 µM 1.75E-5 52 5.10E-4
7 SGTC_67 0335-0847 3.24 266.0 µM 2.18E-5 ubiquinone biosynthesis & proteasome 162 5.87E-4
8 SGTC_3020 9089140 3.19 49.5 µM 2.85E-5 56 6.99E-4
9 SGTC_3024 9090631 3.18 49.5 µM 3.03E-5 19 7.28E-4
10 SGTC_3211 9128781 3.18 49.5 µM 3.06E-5 109 7.33E-4
11 SGTC_2484 5809818 3.13 12.0 µM 4.06E-5 44 8.80E-4
12 SGTC_1939 st074455 3.02 53.6 µM 7.19E-5 78 0.00128
13 SGTC_1642 st009582 2.98 77.7 µM 8.52E-5 RPP1 & pyrimidine depletion 56 0.00143
14 SGTC_841 0251-0215 2.91 91.2 µM 1.21E-4 125 0.00179
15 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 2.91 54.6 µM 1.22E-4 RPP1 & pyrimidine depletion 82 0.00181
16 SGTC_2625 euphol 2.90 100.0 µM 1.28E-4 91 0.00186
17 SGTC_75 0159-0059 2.81 199.0 µM 1.96E-4 fatty acid desaturase (OLE1) 81 0.00245
18 SGTC_2487 5918373 2.78 44.0 µM 2.26E-4 77 0.00269
19 SGTC_1167 k781-0610 2.78 148.0 µM 2.30E-4 RNA processing & uracil transport 82 0.00272
20 SGTC_1430 4049-0248 2.75 69.1 µM 2.66E-4 89 0.00300

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 5.19E-22 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.155 1.43E-19 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.154 3.93E-19 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.147 9.84E-18 YOR213C SAS5 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
0.145 3.29E-17 YEL066W HPA3 hom D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
0.136 3.36E-15 YFR014C CMK1 hom Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication
0.135 4.53E-15 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.130 3.91E-14 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.127 1.65E-13 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.127 1.86E-13 YLR053C_p YLR053C_p hom Putative protein of unknown function
0.125 3.86E-13 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.123 9.53E-13 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.123 1.04E-12 YOL071W EMI5 hom Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.122 1.16E-12 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.122 1.19E-12 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine