YBR250W / SPO23

Protein of unknown function; associates with meiosis-specific protein Spo1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR250W / SPO23

Click on Significant Values for Screen Details ID:SGTC_129|Compound:0088-0017|FD-Score:4.02|P-value:3.90E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:3.51|P-value:2.87E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-5.10|P-value:2.58E-7 ID:SGTC_389|Compound:tpck|FD-Score:3.23|P-value:7.68E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.26|P-value:6.76E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.25|P-value:7.01E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:4.59|P-value:3.28E-6 ID:SGTC_446|Compound:go6976|FD-Score:3.24|P-value:7.36E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.20|P-value:8.19E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-4.53|P-value:4.10E-6 ID:SGTC_787|Compound:4152-0075|FD-Score:3.70|P-value:1.39E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.65|P-value:1.68E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.10|P-value:2.79E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:-3.22|P-value:7.58E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.15|P-value:2.27E-5 ID:SGTC_1688|Compound:st021091|FD-Score:-3.94|P-value:5.21E-5 ID:SGTC_1703|Compound:st026983|FD-Score:-3.50|P-value:2.91E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.17|P-value:9.31E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.36|P-value:4.83E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-3.54|P-value:2.44E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.66|P-value:1.60E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.51|P-value:2.89E-4 ID:SGTC_2063|Compound:5246145|FD-Score:-3.15|P-value:9.61E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.66|P-value:1.63E-4 ID:SGTC_2071|Compound:5230951|FD-Score:4.59|P-value:3.28E-6 ID:SGTC_2072|Compound:5231554|FD-Score:3.53|P-value:2.62E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.38|P-value:4.54E-4 ID:SGTC_2076|Compound:5212012|FD-Score:-3.81|P-value:8.77E-5 ID:SGTC_2311|Compound:7694451|FD-Score:3.98|P-value:4.72E-5 ID:SGTC_2402|Compound:5553605|FD-Score:3.15|P-value:9.92E-4 ID:SGTC_2473|Compound:5854593|FD-Score:3.75|P-value:1.16E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.52|P-value:2.74E-4 ID:SGTC_2967|Compound:9089538|FD-Score:-5.06|P-value:3.15E-7 ID:SGTC_2969|Compound:9091408|FD-Score:-3.28|P-value:6.28E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:4.02|P-value:3.90E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:3.51|P-value:2.87E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-5.10|P-value:2.58E-7 ID:SGTC_389|Compound:tpck|FD-Score:3.23|P-value:7.68E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.26|P-value:6.76E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.25|P-value:7.01E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:4.59|P-value:3.28E-6 ID:SGTC_446|Compound:go6976|FD-Score:3.24|P-value:7.36E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.20|P-value:8.19E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-4.53|P-value:4.10E-6 ID:SGTC_787|Compound:4152-0075|FD-Score:3.70|P-value:1.39E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.65|P-value:1.68E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.10|P-value:2.79E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:-3.22|P-value:7.58E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.15|P-value:2.27E-5 ID:SGTC_1688|Compound:st021091|FD-Score:-3.94|P-value:5.21E-5 ID:SGTC_1703|Compound:st026983|FD-Score:-3.50|P-value:2.91E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.17|P-value:9.31E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.36|P-value:4.83E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-3.54|P-value:2.44E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.66|P-value:1.60E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.51|P-value:2.89E-4 ID:SGTC_2063|Compound:5246145|FD-Score:-3.15|P-value:9.61E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.66|P-value:1.63E-4 ID:SGTC_2071|Compound:5230951|FD-Score:4.59|P-value:3.28E-6 ID:SGTC_2072|Compound:5231554|FD-Score:3.53|P-value:2.62E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.38|P-value:4.54E-4 ID:SGTC_2076|Compound:5212012|FD-Score:-3.81|P-value:8.77E-5 ID:SGTC_2311|Compound:7694451|FD-Score:3.98|P-value:4.72E-5 ID:SGTC_2402|Compound:5553605|FD-Score:3.15|P-value:9.92E-4 ID:SGTC_2473|Compound:5854593|FD-Score:3.75|P-value:1.16E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.52|P-value:2.74E-4 ID:SGTC_2967|Compound:9089538|FD-Score:-5.06|P-value:3.15E-7 ID:SGTC_2969|Compound:9091408|FD-Score:-3.28|P-value:6.28E-4

Top fitness defect scores for YBR250W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_426 0988-0037 4.59 14.6 µM 3.28E-6 ERAD & cell cycle 21 2.22E-6
2 SGTC_2071 5230951 4.59 39.9 µM 3.28E-6 TSC3-RPN4 12 2.22E-6
3 SGTC_1381 2324-0066 4.15 62.1 µM 2.27E-5 26 1.64E-5
4 SGTC_1083 didemethylchlorpromazine sulfoxide 4.10 707.4 nM 2.79E-5 redox potentiating 70 2.03E-5
5 SGTC_129 0088-0017 4.02 176.6 µM 3.90E-5 65 2.87E-5
6 SGTC_2311 7694451 3.98 200.0 µM 4.72E-5 15 3.50E-5
7 SGTC_2473 5854593 3.75 8.9 µM 1.16E-4 15 8.87E-5
8 SGTC_787 4152-0075 3.70 138.0 µM 1.39E-4 27 1.07E-4
9 SGTC_1829 berberine 3.66 14.4 µM 1.60E-4 60S ribosome export 25 1.24E-4
10 SGTC_2070 5230947 3.66 200.0 µM 1.63E-4 13 1.26E-4
11 SGTC_834 0312-0008 3.65 75.7 µM 1.68E-4 NEO1 51 1.30E-4
12 SGTC_2072 5231554 3.53 129.0 µM 2.62E-4 17 2.06E-4
13 SGTC_2752 diclazuril 3.52 33.1 µM 2.74E-4 150 2.15E-4
14 SGTC_213 1246-0773 3.51 967.0 nM 2.87E-4 35 2.26E-4
15 SGTC_1983 st071813 3.51 46.9 µM 2.89E-4 RPP1 & pyrimidine depletion 32 2.28E-4
16 SGTC_2074 5212007 3.38 75.4 µM 4.54E-4 27 3.63E-4
17 SGTC_1724 st037281 3.36 8.3 µM 4.83E-4 67 3.87E-4
18 SGTC_421 streptovitacin 3.26 30.0 mM 6.76E-4 57 5.48E-4
19 SGTC_425 3825-7017 3.25 13.1 µM 7.01E-4 50 5.69E-4
20 SGTC_446 go6976 3.24 132.0 µM 7.36E-4 35 5.98E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.43E-16 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.141 1.82E-16 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.141 2.67E-16 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.107 6.04E-10 YBR218C PYC2 hom Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication
0.100 7.41E-9 YPR066W UBA3 hom Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
0.099 9.61E-9 YER110C KAP123 hom Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1
0.094 5.70E-8 YKL091C YKL091C hom Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study
0.093 6.76E-8 YOL014W_p YOL014W_p hom Putative protein of unknown function
0.093 7.66E-8 YCL001W-B_p YCL001W-B_p hom Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication
0.083 1.53E-6 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.081 2.80E-6 YPL212C PUS1 hom tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA
0.075 1.31E-5 YIR021W-A_p YIR021W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.075 1.42E-5 YDL233W_p MFG1_p hom Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene
0.074 1.65E-5 YBR103W SIF2 hom WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
0.074 1.74E-5 YBR216C YBP1 hom Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication