HIPHOP chemogenomics database

YBR262C / AIM5

Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture

Zygosity: Homozygous strain

fixedexpanded
Profile for YBR262C / AIM5

Click on Significant Values for Screen Details

Top fitness defect scores for YBR262C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2808	7946468	5.39	45.5 µM	7.43E-11		11	3.55E-8
2	SGTC_769	0302-0231	4.76	76.0 µM	7.31E-9		20	9.64E-7
3	SGTC_2602	kawain	4.12	100.0 µM	4.65E-7		20	1.92E-5
4	SGTC_2568	diosmetin	4.07	100.0 µM	6.32E-7		22	2.40E-5
5	SGTC_640	3381-0960	4.02	37.1 µM	8.17E-7		10	2.88E-5
6	SGTC_2309	7664088	4.00	163.9 µM	9.29E-7		28	3.16E-5
7	SGTC_655	k060-0012	3.56	42.0 µM	1.09E-5		24	1.88E-4
8	SGTC_456	gingerol	3.46	170.0 µM	1.82E-5		34	2.72E-4
9	SGTC_2749	bexarotene	3.40	57.4 µM	2.43E-5		43	3.34E-4
10	SGTC_2806	7952793	3.38	58.4 µM	2.77E-5		43	3.68E-4
11	SGTC_2329	6138490	3.16	200.0 µM	7.90E-5		71	7.85E-4
12	SGTC_795	0685-0265	3.13	78.0 µM	9.31E-5	excess fatty acid	60	8.84E-4
13	SGTC_2255	7941087	2.96	197.4 µM	2.02E-4		83	0.00155
14	SGTC_334	1502-1024	2.93	68.5 µM	2.30E-4		53	0.00171
15	SGTC_164	4100-3994	2.91	89.6 µM	2.45E-4		96	0.00179
16	SGTC_2935	9038016	2.86	30.0 µM	3.15E-4		73	0.00214
17	SGTC_2046	4110841	2.84	106.0 µM	3.39E-4	iron homeostasis	71	0.00226
18	SGTC_2752	diclazuril	2.82	33.1 µM	3.73E-4		219	0.00242
19	SGTC_1563	conessine	2.79	56.1 µM	4.23E-4		78	0.00265
20	SGTC_606	k015-0008	2.79	38.6 µM	4.26E-4		71	0.00267

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.328	4.84E-85	YBL036C	YBL036C	hom	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.292	7.09E-67	YKL171W	NNK1	hom	Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.274	6.68E-59	YOR298C-A	MBF1	hom	Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.246	2.74E-47	YLR205C	HMX1	hom	ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.236	9.44E-44	YLR353W	BUD8	hom	Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.233	1.64E-42	YER172C	BRR2	het	RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.223	5.91E-39	YKL179C	COY1	hom	Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.220	3.31E-38	YAL060W	BDH1	hom	NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
0.219	1.11E-37	YMR115W	MGR3	hom	Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.216	1.15E-36	YLR016C	PML1	hom	Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.210	7.11E-35	YAL061W_p	BDH2_p	hom	Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3
0.201	6.59E-32	YEL026W	SNU13	het	RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
0.200	9.39E-32	YBL015W	ACH1	hom	Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.199	3.41E-31	YJR127C	RSF2	hom	Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.193	1.45E-29	YCL035C	GRX1	hom	Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress