YBR276C / PPS1

Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR276C / PPS1

Click on Significant Values for Screen Details ID:SGTC_130|Compound:0136-0219|FD-Score:3.40|P-value:5.32E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:3.12|P-value:1.81E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-3.36|P-value:1.10E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.55|P-value:2.55E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:-4.68|P-value:1.19E-7 ID:SGTC_440|Compound:fluspirilene|FD-Score:-5.29|P-value:2.39E-9 ID:SGTC_496|Compound:calpeptin|FD-Score:3.37|P-value:6.05E-5 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:-3.05|P-value:4.11E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:-5.23|P-value:3.72E-9 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.57|P-value:4.26E-5 ID:SGTC_555|Compound:4296-0685|FD-Score:-3.84|P-value:1.19E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.36|P-value:1.13E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.58|P-value:2.22E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.11|P-value:3.22E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.30|P-value:5.08E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.48|P-value:3.75E-7 ID:SGTC_1115|Compound:galangin|FD-Score:3.80|P-value:7.51E-6 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.90|P-value:4.44E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:4.15|P-value:1.16E-6 ID:SGTC_1400|Compound:3771-8998|FD-Score:2.71|P-value:9.41E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.89|P-value:4.63E-6 ID:SGTC_1608|Compound:st001473|FD-Score:-3.28|P-value:1.61E-4 ID:SGTC_1614|Compound:st002383|FD-Score:-3.54|P-value:4.93E-5 ID:SGTC_1620|Compound:st003704|FD-Score:4.00|P-value:2.67E-6 ID:SGTC_1739|Compound:st037196|FD-Score:2.86|P-value:5.36E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.00|P-value:2.97E-4 ID:SGTC_1751|Compound:st044839|FD-Score:3.05|P-value:2.40E-4 ID:SGTC_1758|Compound:st042942|FD-Score:5.09|P-value:3.81E-9 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.63|P-value:3.13E-14 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.58|P-value:2.27E-5 ID:SGTC_2602|Compound:kawain|FD-Score:3.14|P-value:1.64E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-3.63|P-value:3.29E-5 ID:SGTC_2992|Compound:9074591|FD-Score:-3.25|P-value:1.78E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-2.97|P-value:5.79E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.40|P-value:5.32E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:3.12|P-value:1.81E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-3.36|P-value:1.10E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.55|P-value:2.55E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:-4.68|P-value:1.19E-7 ID:SGTC_440|Compound:fluspirilene|FD-Score:-5.29|P-value:2.39E-9 ID:SGTC_496|Compound:calpeptin|FD-Score:3.37|P-value:6.05E-5 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:-3.05|P-value:4.11E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:-5.23|P-value:3.72E-9 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.57|P-value:4.26E-5 ID:SGTC_555|Compound:4296-0685|FD-Score:-3.84|P-value:1.19E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.36|P-value:1.13E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.58|P-value:2.22E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.11|P-value:3.22E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.30|P-value:5.08E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.48|P-value:3.75E-7 ID:SGTC_1115|Compound:galangin|FD-Score:3.80|P-value:7.51E-6 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.90|P-value:4.44E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:4.15|P-value:1.16E-6 ID:SGTC_1400|Compound:3771-8998|FD-Score:2.71|P-value:9.41E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.89|P-value:4.63E-6 ID:SGTC_1608|Compound:st001473|FD-Score:-3.28|P-value:1.61E-4 ID:SGTC_1614|Compound:st002383|FD-Score:-3.54|P-value:4.93E-5 ID:SGTC_1620|Compound:st003704|FD-Score:4.00|P-value:2.67E-6 ID:SGTC_1739|Compound:st037196|FD-Score:2.86|P-value:5.36E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.00|P-value:2.97E-4 ID:SGTC_1751|Compound:st044839|FD-Score:3.05|P-value:2.40E-4 ID:SGTC_1758|Compound:st042942|FD-Score:5.09|P-value:3.81E-9 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.63|P-value:3.13E-14 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.58|P-value:2.27E-5 ID:SGTC_2602|Compound:kawain|FD-Score:3.14|P-value:1.64E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-3.63|P-value:3.29E-5 ID:SGTC_2992|Compound:9074591|FD-Score:-3.25|P-value:1.78E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-2.97|P-value:5.79E-4

Top fitness defect scores for YBR276C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2583 asiatic acid 6.63 100.0 µM 3.13E-14 5 1.63E-11
2 SGTC_1758 st042942 5.09 75.2 µM 3.81E-9 8 1.76E-7
3 SGTC_1083 didemethylchlorpromazine sulfoxide 4.30 707.4 nM 5.08E-7 redox potentiating 60 8.54E-6
4 SGTC_1343 1487-0095 4.15 224.0 µM 1.16E-6 8 1.65E-5
5 SGTC_1620 st003704 4.00 16.5 µM 2.67E-6 13 3.19E-5
6 SGTC_1607 st000305 3.89 50.6 µM 4.63E-6 13 4.93E-5
7 SGTC_1115 galangin 3.80 695.7 nM 7.51E-6 RPP1 & pyrimidine depletion 19 7.24E-5
8 SGTC_563 tetrahydrosecaminediol 3.58 614.0 µM 2.22E-5 amide catabolism 21 1.71E-4
9 SGTC_2594 a-mangostin 3.58 100.0 µM 2.27E-5 43 1.74E-4
10 SGTC_408 cantharidin 3.55 100.0 µM 2.55E-5 cell wall signaling 33 1.91E-4
11 SGTC_130 0136-0219 3.40 337.7 µM 5.32E-5 43 3.43E-4
12 SGTC_496 calpeptin 3.37 138.0 µM 6.05E-5 33 3.80E-4
13 SGTC_2602 kawain 3.14 100.0 µM 1.64E-4 67 8.38E-4
14 SGTC_382 3229-0966 3.12 23.2 µM 1.81E-4 49 9.08E-4
15 SGTC_1751 st044839 3.05 27.2 µM 2.40E-4 Golgi 30 0.00113
16 SGTC_1748 st037455 3.00 53.6 µM 2.97E-4 81 0.00134
17 SGTC_1270 0831-1170 2.90 17.3 µM 4.44E-4 56 0.00185
18 SGTC_1739 st037196 2.86 92.5 µM 5.36E-4 78 0.00215
19 SGTC_1400 3771-8998 2.71 51.5 µM 9.41E-4 43 0.00336
20 SGTC_1618 st003135 2.69 44.5 µM 0.00101 68 0.00356

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.202 3.16E-32 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.178 2.67E-25 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.170 4.32E-23 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.162 3.32E-21 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
0.162 3.38E-21 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.152 8.15E-19 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.146 2.16E-17 YHR132W-A IGO2 hom Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p
0.142 1.27E-16 YLR346C_p YLR346C_p hom Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
0.140 3.76E-16 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.138 1.03E-15 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.137 1.44E-15 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.134 7.16E-15 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.134 8.23E-15 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.133 9.44E-15 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.125 3.63E-13 YLR241W_p YLR241W_p hom Putative protein of unknown function, may be involved in detoxification