YBR289W / SNF5

Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR289W / SNF5

Click on Significant Values for Screen Details ID:SGTC_103|Compound:0844-0104|FD-Score:-3.82|P-value:1.13E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-2.80|P-value:8.49E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.26|P-value:1.40E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-6.59|P-value:2.55E-13 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.71|P-value:1.02E-7 ID:SGTC_912|Compound:3474-0017|FD-Score:-4.35|P-value:7.85E-7 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-2.85|P-value:7.16E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:-3.84|P-value:1.01E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:-5.42|P-value:1.28E-9 ID:SGTC_987|Compound:1497-1013|FD-Score:-3.52|P-value:4.65E-5 ID:SGTC_989|Compound:1501-0895|FD-Score:-5.30|P-value:2.80E-9 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.51|P-value:4.78E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:-3.70|P-value:2.03E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:-5.43|P-value:1.21E-9 ID:SGTC_1172|Compound:0370-0043|FD-Score:-5.04|P-value:1.47E-8 ID:SGTC_1181|Compound:1222-0449|FD-Score:-7.29|P-value:7.60E-16 ID:SGTC_1183|Compound:1254-0324|FD-Score:-3.33|P-value:1.04E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:-4.73|P-value:8.96E-8 ID:SGTC_1226|Compound:3909-7979|FD-Score:-4.94|P-value:2.58E-8 ID:SGTC_1229|Compound:0139-0193|FD-Score:-5.92|P-value:4.13E-11 ID:SGTC_1235|Compound:benzylparaben|FD-Score:-4.18|P-value:1.89E-6 ID:SGTC_1273|Compound:0849-0096|FD-Score:-2.97|P-value:4.57E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.20|P-value:1.79E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:-4.40|P-value:5.88E-7 ID:SGTC_1294|Compound:1000-1494|FD-Score:-4.69|P-value:1.13E-7 ID:SGTC_1300|Compound:1094-0077|FD-Score:-2.82|P-value:8.01E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:-5.88|P-value:5.29E-11 ID:SGTC_1311|Compound:1190-0148|FD-Score:-3.19|P-value:1.89E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:-3.13|P-value:2.42E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-6.50|P-value:5.26E-13 ID:SGTC_1331|Compound:1472-0049|FD-Score:-4.25|P-value:1.29E-6 ID:SGTC_1344|Compound:1488-0097|FD-Score:-3.48|P-value:5.54E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-2.91|P-value:5.75E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:-2.79|P-value:8.79E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.38|P-value:8.28E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.03|P-value:3.57E-4 ID:SGTC_1657|Compound:st012939|FD-Score:-4.05|P-value:3.62E-6 ID:SGTC_1743|Compound:st037606|FD-Score:-3.28|P-value:1.29E-4 ID:SGTC_1970|Compound:st070122|FD-Score:-3.06|P-value:3.12E-4 ID:SGTC_1973|Compound:st070275|FD-Score:-3.25|P-value:1.48E-4 ID:SGTC_1974|Compound:st069448|FD-Score:-2.89|P-value:6.13E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-2.99|P-value:4.12E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-3.55|P-value:3.99E-5 ID:SGTC_2104|Compound:5389443|FD-Score:-2.97|P-value:4.58E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-3.19|P-value:1.84E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-4.63|P-value:1.64E-7 ID:SGTC_2272|Compound:7805186|FD-Score:-2.83|P-value:7.71E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.00|P-value:9.51E-4 ID:SGTC_2483|Compound:5729050|FD-Score:-2.84|P-value:7.48E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-3.77|P-value:1.45E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.46|P-value:1.57E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.13|P-value:5.90E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-3.74|P-value:1.69E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.17|P-value:4.91E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.08|P-value:7.07E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.48|P-value:1.42E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-2.86|P-value:6.81E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-4.30|P-value:1.02E-6 ID:SGTC_2974|Compound:9094440|FD-Score:3.01|P-value:9.01E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-3.04|P-value:3.37E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-3.42|P-value:6.97E-5 ID:SGTC_3217|Compound:9129673|FD-Score:-3.93|P-value:6.64E-6 ID:SGTC_3244|Compound:9134489|FD-Score:3.47|P-value:1.49E-4 ID:SGTC_3247|Compound:9135149|FD-Score:-2.94|P-value:5.06E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-2.99|P-value:4.17E-4 ID:SGTC_3316|Compound:9136639|FD-Score:-4.81|P-value:5.76E-8 ID:SGTC_3333|Compound:9141820|FD-Score:-5.02|P-value:1.61E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.82|P-value:1.13E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-2.80|P-value:8.49E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.26|P-value:1.40E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-6.59|P-value:2.55E-13 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.71|P-value:1.02E-7 ID:SGTC_912|Compound:3474-0017|FD-Score:-4.35|P-value:7.85E-7 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-2.85|P-value:7.16E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:-3.84|P-value:1.01E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:-5.42|P-value:1.28E-9 ID:SGTC_987|Compound:1497-1013|FD-Score:-3.52|P-value:4.65E-5 ID:SGTC_989|Compound:1501-0895|FD-Score:-5.30|P-value:2.80E-9 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.51|P-value:4.78E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:-3.70|P-value:2.03E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:-5.43|P-value:1.21E-9 ID:SGTC_1172|Compound:0370-0043|FD-Score:-5.04|P-value:1.47E-8 ID:SGTC_1181|Compound:1222-0449|FD-Score:-7.29|P-value:7.60E-16 ID:SGTC_1183|Compound:1254-0324|FD-Score:-3.33|P-value:1.04E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:-4.73|P-value:8.96E-8 ID:SGTC_1226|Compound:3909-7979|FD-Score:-4.94|P-value:2.58E-8 ID:SGTC_1229|Compound:0139-0193|FD-Score:-5.92|P-value:4.13E-11 ID:SGTC_1235|Compound:benzylparaben|FD-Score:-4.18|P-value:1.89E-6 ID:SGTC_1273|Compound:0849-0096|FD-Score:-2.97|P-value:4.57E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.20|P-value:1.79E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:-4.40|P-value:5.88E-7 ID:SGTC_1294|Compound:1000-1494|FD-Score:-4.69|P-value:1.13E-7 ID:SGTC_1300|Compound:1094-0077|FD-Score:-2.82|P-value:8.01E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:-5.88|P-value:5.29E-11 ID:SGTC_1311|Compound:1190-0148|FD-Score:-3.19|P-value:1.89E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:-3.13|P-value:2.42E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-6.50|P-value:5.26E-13 ID:SGTC_1331|Compound:1472-0049|FD-Score:-4.25|P-value:1.29E-6 ID:SGTC_1344|Compound:1488-0097|FD-Score:-3.48|P-value:5.54E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-2.91|P-value:5.75E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:-2.79|P-value:8.79E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.38|P-value:8.28E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.03|P-value:3.57E-4 ID:SGTC_1657|Compound:st012939|FD-Score:-4.05|P-value:3.62E-6 ID:SGTC_1743|Compound:st037606|FD-Score:-3.28|P-value:1.29E-4 ID:SGTC_1970|Compound:st070122|FD-Score:-3.06|P-value:3.12E-4 ID:SGTC_1973|Compound:st070275|FD-Score:-3.25|P-value:1.48E-4 ID:SGTC_1974|Compound:st069448|FD-Score:-2.89|P-value:6.13E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-2.99|P-value:4.12E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-3.55|P-value:3.99E-5 ID:SGTC_2104|Compound:5389443|FD-Score:-2.97|P-value:4.58E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-3.19|P-value:1.84E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-4.63|P-value:1.64E-7 ID:SGTC_2272|Compound:7805186|FD-Score:-2.83|P-value:7.71E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.00|P-value:9.51E-4 ID:SGTC_2483|Compound:5729050|FD-Score:-2.84|P-value:7.48E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-3.77|P-value:1.45E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.46|P-value:1.57E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.13|P-value:5.90E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-3.74|P-value:1.69E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.17|P-value:4.91E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.08|P-value:7.07E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.48|P-value:1.42E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-2.86|P-value:6.81E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-4.30|P-value:1.02E-6 ID:SGTC_2974|Compound:9094440|FD-Score:3.01|P-value:9.01E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-3.04|P-value:3.37E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-3.42|P-value:6.97E-5 ID:SGTC_3217|Compound:9129673|FD-Score:-3.93|P-value:6.64E-6 ID:SGTC_3244|Compound:9134489|FD-Score:3.47|P-value:1.49E-4 ID:SGTC_3247|Compound:9135149|FD-Score:-2.94|P-value:5.06E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-2.99|P-value:4.17E-4 ID:SGTC_3316|Compound:9136639|FD-Score:-4.81|P-value:5.76E-8 ID:SGTC_3333|Compound:9141820|FD-Score:-5.02|P-value:1.61E-8

Top fitness defect scores for YBR289W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2949 9072542 3.48 2.2 µM 1.42E-4 TSC3-RPN4 56 2.48E-4
2 SGTC_3244 9134489 3.47 49.5 µM 1.49E-4 32 2.58E-4
3 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 3.46 63.6 µM 1.57E-4 61 2.71E-4
4 SGTC_2690 usnic acid 3.17 100.0 µM 4.91E-4 64 7.52E-4
5 SGTC_2536 dehydroabietamide 3.13 32.0 µM 5.90E-4 81 8.89E-4
6 SGTC_2944 9067346 3.08 25.6 µM 7.07E-4 70 0.00105
7 SGTC_2974 9094440 3.01 9.7 µM 9.01E-4 ergosterol biosynthesis 97 0.00130
8 SGTC_2467 5474540 3.00 200.0 µM 9.51E-4 63 0.00136
9 SGTC_2691 st077356 2.98 60.2 µM 0.00101 79 0.00144
10 SGTC_1746 st038117 2.94 42.0 µM 0.00117 84 0.00165
11 SGTC_383 2324-0395 2.91 7.4 µM 0.00130 azole & statin 104 0.00181
12 SGTC_1891 st059073 2.86 26.2 µM 0.00153 TSC3-RPN4 76 0.00210
13 SGTC_1055 3448-0672 2.81 86.0 µM 0.00183 98 0.00247
14 SGTC_1056 3448-1962 2.78 115.0 µM 0.00207 amide catabolism 80 0.00275
15 SGTC_1948 st076329 2.77 66.6 µM 0.00214 100 0.00283
16 SGTC_1895 st058434 2.76 18.3 µM 0.00217 66 0.00287
17 SGTC_2460 5552655 2.76 174.2 µM 0.00222 amide catabolism 101 0.00293
18 SGTC_3330 9141424 2.74 71.4 µM 0.00231 amide catabolism 80 0.00304
19 SGTC_2692 st077426 2.73 47.7 µM 0.00245 91 0.00321
20 SGTC_1617 st002906 2.71 78.0 µM 0.00262 104 0.00340

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 2.60E-12 YHL025W SNF6 hom Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions
0.081 2.90E-6 YER014C-A BUD25 hom Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
0.076 1.11E-5 YNL080C EOS1 hom Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene
0.076 1.15E-5 YEL038W UTR4 hom Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus
0.075 1.20E-5 YNL297C MON2 hom Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins
0.071 3.46E-5 YHR123W EPT1 hom sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication
0.066 1.28E-4 YMR160W YMR160W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene; relative distribution within the vacuolar membrane changes upon DNA replication stress
0.066 1.35E-4 YPR098C YPR098C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.066 1.41E-4 YLR022C SDO1 het Essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes
0.064 2.11E-4 YOR140W SFL1 hom Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
0.064 2.15E-4 YOR114W_p YOR114W_p hom Putative protein of unknown function; null mutant is viable
0.061 3.67E-4 YCL029C BIK1 hom Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170
0.060 5.45E-4 YGL234W ADE5,7 hom Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
0.059 5.94E-4 YPL085W SEC16 het COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p
0.059 6.14E-4 YAL054C ACS1 hom Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions