YCL022C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL022C / YCL022C

Click on Significant Values for Screen Details ID:SGTC_153|Compound:4077-0274|FD-Score:3.42|P-value:5.48E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-2.83|P-value:9.84E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.01|P-value:3.18E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:-4.11|P-value:3.15E-6 ID:SGTC_337|Compound:1315-0038|FD-Score:3.31|P-value:8.76E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.02|P-value:4.84E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-3.97|P-value:6.48E-6 ID:SGTC_783|Compound:0848-0141|FD-Score:-4.50|P-value:3.59E-7 ID:SGTC_865|Compound:0488-0499|FD-Score:4.04|P-value:2.55E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:2.77|P-value:8.13E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:5.28|P-value:1.41E-9 ID:SGTC_977|Compound:1348-1378|FD-Score:-4.11|P-value:3.14E-6 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.04|P-value:4.39E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.10|P-value:3.49E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-2.92|P-value:7.10E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:2.78|P-value:8.01E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.02|P-value:4.86E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:2.90|P-value:4.99E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-2.97|P-value:5.76E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.46|P-value:4.46E-5 ID:SGTC_1746|Compound:st038117|FD-Score:-3.52|P-value:5.63E-5 ID:SGTC_1749|Compound:st037932|FD-Score:-3.36|P-value:1.16E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-2.98|P-value:5.58E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-2.97|P-value:5.80E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.74|P-value:9.27E-4 ID:SGTC_2139|Compound:5578692|FD-Score:2.82|P-value:6.77E-4 ID:SGTC_2282|Compound:7944268|FD-Score:2.92|P-value:4.57E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-3.29|P-value:1.54E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.14|P-value:1.89E-4 ID:SGTC_2435|Compound:5706476|FD-Score:2.83|P-value:6.69E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-2.87|P-value:8.56E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:2.91|P-value:4.74E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.12|P-value:3.15E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.56|P-value:4.77E-5 ID:SGTC_3009|Compound:9080819|FD-Score:3.89|P-value:5.50E-6 ID:SGTC_3070|Compound:9117005|FD-Score:-3.93|P-value:7.97E-6 ID:SGTC_3225|Compound:9130819|FD-Score:4.09|P-value:1.98E-6 ID:SGTC_3242|Compound:9133940|FD-Score:2.82|P-value:6.92E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.42|P-value:5.48E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-2.83|P-value:9.84E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.01|P-value:3.18E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:-4.11|P-value:3.15E-6 ID:SGTC_337|Compound:1315-0038|FD-Score:3.31|P-value:8.76E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.02|P-value:4.84E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-3.97|P-value:6.48E-6 ID:SGTC_783|Compound:0848-0141|FD-Score:-4.50|P-value:3.59E-7 ID:SGTC_865|Compound:0488-0499|FD-Score:4.04|P-value:2.55E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:2.77|P-value:8.13E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:5.28|P-value:1.41E-9 ID:SGTC_977|Compound:1348-1378|FD-Score:-4.11|P-value:3.14E-6 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.04|P-value:4.39E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.10|P-value:3.49E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-2.92|P-value:7.10E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:2.78|P-value:8.01E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.02|P-value:4.86E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:2.90|P-value:4.99E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-2.97|P-value:5.76E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.46|P-value:4.46E-5 ID:SGTC_1746|Compound:st038117|FD-Score:-3.52|P-value:5.63E-5 ID:SGTC_1749|Compound:st037932|FD-Score:-3.36|P-value:1.16E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-2.98|P-value:5.58E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-2.97|P-value:5.80E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.74|P-value:9.27E-4 ID:SGTC_2139|Compound:5578692|FD-Score:2.82|P-value:6.77E-4 ID:SGTC_2282|Compound:7944268|FD-Score:2.92|P-value:4.57E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-3.29|P-value:1.54E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.14|P-value:1.89E-4 ID:SGTC_2435|Compound:5706476|FD-Score:2.83|P-value:6.69E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-2.87|P-value:8.56E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:2.91|P-value:4.74E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.12|P-value:3.15E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.56|P-value:4.77E-5 ID:SGTC_3009|Compound:9080819|FD-Score:3.89|P-value:5.50E-6 ID:SGTC_3070|Compound:9117005|FD-Score:-3.93|P-value:7.97E-6 ID:SGTC_3225|Compound:9130819|FD-Score:4.09|P-value:1.98E-6 ID:SGTC_3242|Compound:9133940|FD-Score:2.82|P-value:6.92E-4

Top fitness defect scores for YCL022C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_874 0599-0792 5.28 117.0 µM 1.41E-9 11 6.45E-8
2 SGTC_3225 9130819 4.09 49.5 µM 1.98E-6 amide catabolism 25 2.19E-5
3 SGTC_865 0488-0499 4.04 301.0 µM 2.55E-6 16 2.68E-5
4 SGTC_3009 9080819 3.89 71.4 µM 5.50E-6 18 4.97E-5
5 SGTC_1739 st037196 3.46 92.5 µM 4.46E-5 39 2.67E-4
6 SGTC_153 4077-0274 3.42 519.7 µM 5.48E-5 32 3.15E-4
7 SGTC_337 1315-0038 3.31 354.0 µM 8.76E-5 amide catabolism 45 4.60E-4
8 SGTC_2376 9072922 3.14 81.3 µM 1.89E-4 71 8.54E-4
9 SGTC_326 k292-0812 3.01 17.5 µM 3.18E-4 28 0.00130
10 SGTC_2282 7944268 2.92 200.0 µM 4.57E-4 RPP1 & pyrimidine depletion 94 0.00174
11 SGTC_2642 cholecalciferol 2.91 100.0 µM 4.74E-4 51 0.00179
12 SGTC_1276 0871-0068 2.90 94.2 µM 4.99E-4 54 0.00187
13 SGTC_2435 5706476 2.83 10.6 µM 6.69E-4 83 0.00236
14 SGTC_2139 5578692 2.82 56.5 µM 6.77E-4 superoxide 55 0.00239
15 SGTC_3242 9133940 2.82 49.5 µM 6.92E-4 58 0.00243
16 SGTC_1186 1319-0216 2.78 26.0 µM 8.01E-4 81 0.00273
17 SGTC_871 0574-0004 2.77 149.0 µM 8.13E-4 122 0.00277
18 SGTC_2126 5251174 2.74 33.9 µM 9.27E-4 133 0.00307
19 SGTC_2104 5389443 2.72 200.0 µM 0.00100 85 0.00327
20 SGTC_1128 3448-9350 2.70 235.0 µM 0.00106 92 0.00344

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 9.75E-19 YCL002C_p YCL002C_p hom Putative protein of unknown function; YCL002C is not an essential gene
0.093 7.48E-8 YEL056W HAT2 hom Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
0.090 1.69E-7 YLR289W GUF1 hom Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor
0.089 3.11E-7 YDR029W_d YDR029W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.087 3.85E-7 YHR124W NDT80 hom Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)
0.086 6.81E-7 YPL116W HOS3 hom Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
0.084 9.70E-7 YNL324W_d YNL324W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.083 1.53E-6 YOR375C GDH1 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication
0.081 2.64E-6 YBR138C_p YBR138C_p hom Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene
0.078 5.51E-6 YIL011W TIR3 hom Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
0.077 7.27E-6 YGR134W CAF130 hom Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
0.074 1.93E-5 YGR153W_p YGR153W_p hom Putative protein of unknown function
0.073 2.08E-5 YFR039C_p YFR039C_p hom Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces
0.070 4.63E-5 YLL039C UBI4 hom Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress
0.070 4.85E-5 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization