HIPHOP chemogenomics database

YCL046W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C

Zygosity: Homozygous strain

fixedexpanded
Profile for YCL046W / YCL046W

Click on Significant Values for Screen Details

Top fitness defect scores for YCL046W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1750	st081859	19.50	2.4 µM	7.77E-84	endomembrane recycling	17	4.38E-85
2	SGTC_67	0335-0847	8.63	266.0 µM	7.49E-18	ubiquinone biosynthesis & proteasome	34	3.08E-18
3	SGTC_2696	st077691	7.83	74.3 µM	5.25E-15		2	2.40E-15
4	SGTC_279	1273-0055	5.92	2.9 µM	2.81E-9	azole & statin	15	1.62E-9
5	SGTC_3076	9116187	5.14	49.5 µM	2.13E-7		5	1.34E-7
6	SGTC_1675	st018485	5.10	24.5 µM	2.70E-7	60S ribosome export	11	1.70E-7
7	SGTC_176	1486-1328	5.09	72.8 µM	2.88E-7		30	1.82E-7
8	SGTC_1830	st055982	4.80	50.3 µM	1.19E-6		5	7.77E-7
9	SGTC_163	1327-0036	4.59	7.5 µM	3.40E-6		80	2.26E-6
10	SGTC_1550	gossypolone	4.56	36.6 µM	3.85E-6		5	2.57E-6
11	SGTC_2084	5306078	4.53	60.6 µM	4.39E-6		8	2.94E-6
12	SGTC_2241	6772625	4.52	37.8 µM	4.66E-6		16	3.13E-6
13	SGTC_562	3772-2733	4.45	112.0 µM	6.27E-6	ERG2	65	4.23E-6
14	SGTC_2450	5739737	4.44	12.9 µM	6.75E-6		13	4.57E-6
15	SGTC_684	1140-0066	4.36	328.0 µM	9.62E-6	Golgi	14	6.56E-6
16	SGTC_3173	9105693	4.27	49.5 µM	1.45E-5		14	9.98E-6
17	SGTC_2588	indole-3-carbinol	4.24	100.0 µM	1.65E-5		38	1.14E-5
18	SGTC_1770	st043884	4.23	66.3 µM	1.67E-5		11	1.15E-5
19	SGTC_2149	5554786	4.12	194.8 µM	2.66E-5	cell wall signaling	32	1.86E-5
20	SGTC_2594	a-mangostin	4.11	100.0 µM	2.84E-5		28	1.99E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.429	4.66E-150	YMR126C_p	DLT1_p	hom	Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.356	7.96E-101	YPR029C	APL4	hom	Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.346	7.47E-95	YPR153W	YPR153W	hom	Putative protein of unknown function
0.314	2.09E-77	YKL098W	MTC2	hom	Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.288	7.44E-65	YJR088C	EMC2	hom	Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.276	1.15E-59	YML072C	TCB3	hom	Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.261	3.07E-53	YMR007W_d	YMR007W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.246	2.77E-47	YPL077C_p	YPL077C_p	hom	Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.225	1.16E-39	YKL207W	EMC3	hom	Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111
0.220	7.46E-38	YCL045C	EMC1	hom	Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090
0.215	3.10E-36	YLR169W_d	YLR169W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.213	1.16E-35	YBR255W	MTC4	hom	Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1
0.207	1.23E-33	YGR202C	PCT1	hom	Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.205	4.67E-33	YHL019C	APM2	hom	Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.205	5.35E-33	YKL136W_d	YKL136W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C