YCL049C_p

Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL049C / YCL049C

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:4.14|P-value:1.27E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.18|P-value:5.37E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.18|P-value:5.43E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.16|P-value:6.61E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.14|P-value:7.15E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:3.24|P-value:4.92E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.11|P-value:7.99E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.27|P-value:4.53E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.57|P-value:1.40E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.48|P-value:2.00E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.43|P-value:2.48E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.29|P-value:4.16E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:-3.74|P-value:6.01E-5 ID:SGTC_904|Compound:1141-0088|FD-Score:3.31|P-value:3.78E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.01|P-value:2.27E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.32|P-value:3.17E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:4.03|P-value:2.07E-5 ID:SGTC_1274|Compound:0865-0114|FD-Score:-3.08|P-value:7.75E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.11|P-value:7.99E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:4.89|P-value:3.29E-7 ID:SGTC_1407|Compound:3909-7909|FD-Score:4.05|P-value:1.90E-5 ID:SGTC_1444|Compound:4112-3581|FD-Score:4.53|P-value:2.03E-6 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.20|P-value:5.64E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.49|P-value:2.40E-6 ID:SGTC_1570|Compound:verbenone|FD-Score:6.68|P-value:4.87E-12 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.14|P-value:7.10E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-3.49|P-value:1.70E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.68|P-value:9.01E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-5.24|P-value:3.89E-8 ID:SGTC_1981|Compound:st071826|FD-Score:3.63|P-value:1.13E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.30|P-value:3.93E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.31|P-value:3.84E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.06|P-value:9.31E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.05|P-value:9.62E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.28|P-value:4.33E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.31|P-value:3.32E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:6.21|P-value:1.24E-10 ID:SGTC_2591|Compound:skatole|FD-Score:3.49|P-value:1.93E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.67|P-value:8.22E-5 ID:SGTC_2625|Compound:euphol|FD-Score:3.99|P-value:2.44E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.79|P-value:5.02E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:5.70|P-value:3.15E-9 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.08|P-value:8.63E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.61|P-value:1.19E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.23|P-value:4.55E-4 ID:SGTC_2859|Compound:9028643|FD-Score:3.93|P-value:3.26E-5 ID:SGTC_2975|Compound:9084847|FD-Score:-4.19|P-value:8.34E-6 ID:SGTC_48|Compound:0382-0018|FD-Score:4.14|P-value:1.27E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.18|P-value:5.37E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.18|P-value:5.43E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.16|P-value:6.61E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.14|P-value:7.15E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:3.24|P-value:4.92E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.11|P-value:7.99E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.27|P-value:4.53E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.57|P-value:1.40E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.48|P-value:2.00E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.43|P-value:2.48E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.29|P-value:4.16E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:-3.74|P-value:6.01E-5 ID:SGTC_904|Compound:1141-0088|FD-Score:3.31|P-value:3.78E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.01|P-value:2.27E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.32|P-value:3.17E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:4.03|P-value:2.07E-5 ID:SGTC_1274|Compound:0865-0114|FD-Score:-3.08|P-value:7.75E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.11|P-value:7.99E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:4.89|P-value:3.29E-7 ID:SGTC_1407|Compound:3909-7909|FD-Score:4.05|P-value:1.90E-5 ID:SGTC_1444|Compound:4112-3581|FD-Score:4.53|P-value:2.03E-6 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.20|P-value:5.64E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.49|P-value:2.40E-6 ID:SGTC_1570|Compound:verbenone|FD-Score:6.68|P-value:4.87E-12 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.14|P-value:7.10E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-3.49|P-value:1.70E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.68|P-value:9.01E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-5.24|P-value:3.89E-8 ID:SGTC_1981|Compound:st071826|FD-Score:3.63|P-value:1.13E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.30|P-value:3.93E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.31|P-value:3.84E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.06|P-value:9.31E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.05|P-value:9.62E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.28|P-value:4.33E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.31|P-value:3.32E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:6.21|P-value:1.24E-10 ID:SGTC_2591|Compound:skatole|FD-Score:3.49|P-value:1.93E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.67|P-value:8.22E-5 ID:SGTC_2625|Compound:euphol|FD-Score:3.99|P-value:2.44E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.79|P-value:5.02E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:5.70|P-value:3.15E-9 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.08|P-value:8.63E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.61|P-value:1.19E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.23|P-value:4.55E-4 ID:SGTC_2859|Compound:9028643|FD-Score:3.93|P-value:3.26E-5 ID:SGTC_2975|Compound:9084847|FD-Score:-4.19|P-value:8.34E-6

Top fitness defect scores for YCL049C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1570 verbenone 6.68 133.0 µM 4.87E-12 1 1.18E-11
2 SGTC_2581 avocatin a 6.21 64.0 µM 1.24E-10 sphingolipid biosynthesis & PDR1 16 2.65E-10
3 SGTC_2686 alizarin 5.70 95.4 µM 3.15E-9 RPP1 & pyrimidine depletion 9 5.93E-9
4 SGTC_1345 1488-0192 4.89 31.4 µM 3.29E-7 6 5.17E-7
5 SGTC_1444 4112-3581 4.53 28.0 µM 2.03E-6 2 2.98E-6
6 SGTC_1520 flindersine 4.49 88.0 µM 2.40E-6 18 3.50E-6
7 SGTC_48 0382-0018 4.14 55.0 µM 1.27E-5 4 1.74E-5
8 SGTC_1407 3909-7909 4.05 12.3 µM 1.90E-5 60S ribosome export 13 2.57E-5
9 SGTC_1123 mangostin 4.03 811.3 nM 2.07E-5 mitochondrial response to ROS 37 2.79E-5
10 SGTC_1017 4239-0030 4.01 168.0 µM 2.27E-5 25 3.05E-5
11 SGTC_2625 euphol 3.99 100.0 µM 2.44E-5 27 3.27E-5
12 SGTC_2859 9028643 3.93 45.5 µM 3.26E-5 15 4.33E-5
13 SGTC_1938 st074717 3.68 56.4 µM 9.01E-5 18 1.15E-4
14 SGTC_1981 st071826 3.63 47.0 µM 1.13E-4 21 1.43E-4
15 SGTC_2761 levamisole 3.61 97.9 µM 1.19E-4 24 1.50E-4
16 SGTC_774 k060-0086 3.57 136.0 µM 1.40E-4 28 1.76E-4
17 SGTC_2591 skatole 3.49 100.0 µM 1.93E-4 36 2.40E-4
18 SGTC_833 3852-0053 3.48 558.0 µM 2.00E-4 30 2.48E-4
19 SGTC_859 0439-0102 3.43 54.6 µM 2.48E-4 redox potentiating 26 3.05E-4
20 SGTC_904 1141-0088 3.31 396.0 µM 3.78E-4 30 4.59E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 4.92E-11 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.110 2.03E-10 YJL158C CIS3 hom Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
0.109 2.57E-10 YDR242W AMD2 hom Putative amidase
0.107 4.21E-10 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.102 2.81E-9 YNL306W MRPS18 het Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins
0.099 8.81E-9 YKL174C TPO5 hom Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles
0.092 7.94E-8 YGR207C CIR1 hom Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response
0.092 8.09E-8 YLR276C DBP9 het DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
0.092 9.41E-8 YMR103C_d YMR103C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.089 2.54E-7 YJR044C VPS55 hom Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)
0.089 2.77E-7 YMR130W_p YMR130W_p hom Putative protein of unknown function; YMR130W is not an essential gene
0.087 3.93E-7 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.087 4.08E-7 YBR213W MET8 hom Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.084 9.65E-7 YMR164C MSS11 hom Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals
0.084 1.19E-6 YLR267W_p BOP2_p hom Protein of unknown function