YCL074W

Pseudogene: encodes fragment of Ty Pol protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL074W / YCL074W

Click on Significant Values for Screen Details ID:SGTC_345|Compound:1362-0200|FD-Score:-3.19|P-value:5.10E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.23|P-value:4.29E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.80|P-value:4.68E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.68|P-value:7.89E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.28|P-value:5.16E-6 ID:SGTC_693|Compound:4161-2696|FD-Score:4.23|P-value:6.82E-6 ID:SGTC_873|Compound:0591-4978|FD-Score:3.75|P-value:5.77E-5 ID:SGTC_883|Compound:0850-0245|FD-Score:4.72|P-value:6.10E-7 ID:SGTC_936|Compound:3005-4620|FD-Score:-4.19|P-value:7.94E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:-5.59|P-value:4.23E-9 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.31|P-value:3.43E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:4.25|P-value:6.27E-6 ID:SGTC_1889|Compound:st059080|FD-Score:3.94|P-value:2.59E-5 ID:SGTC_1891|Compound:st059073|FD-Score:-3.55|P-value:1.28E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-4.05|P-value:1.52E-5 ID:SGTC_1906|Compound:st060206|FD-Score:4.20|P-value:8.03E-6 ID:SGTC_2476|Compound:5806916|FD-Score:-3.37|P-value:2.57E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-4.10|P-value:1.21E-5 ID:SGTC_2902|Compound:5787006|FD-Score:-4.74|P-value:5.28E-7 ID:SGTC_2908|Compound:7930301|FD-Score:-4.94|P-value:1.77E-7 ID:SGTC_2910|Compound:7948405|FD-Score:-5.53|P-value:6.18E-9 ID:SGTC_2914|Compound:7968218|FD-Score:-5.50|P-value:7.17E-9 ID:SGTC_2955|Compound:9076254|FD-Score:-3.34|P-value:2.84E-4 ID:SGTC_3206|Compound:9114350|FD-Score:3.33|P-value:3.11E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.19|P-value:5.10E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.23|P-value:4.29E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.80|P-value:4.68E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.68|P-value:7.89E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.28|P-value:5.16E-6 ID:SGTC_693|Compound:4161-2696|FD-Score:4.23|P-value:6.82E-6 ID:SGTC_873|Compound:0591-4978|FD-Score:3.75|P-value:5.77E-5 ID:SGTC_883|Compound:0850-0245|FD-Score:4.72|P-value:6.10E-7 ID:SGTC_936|Compound:3005-4620|FD-Score:-4.19|P-value:7.94E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:-5.59|P-value:4.23E-9 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.31|P-value:3.43E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:4.25|P-value:6.27E-6 ID:SGTC_1889|Compound:st059080|FD-Score:3.94|P-value:2.59E-5 ID:SGTC_1891|Compound:st059073|FD-Score:-3.55|P-value:1.28E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-4.05|P-value:1.52E-5 ID:SGTC_1906|Compound:st060206|FD-Score:4.20|P-value:8.03E-6 ID:SGTC_2476|Compound:5806916|FD-Score:-3.37|P-value:2.57E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-4.10|P-value:1.21E-5 ID:SGTC_2902|Compound:5787006|FD-Score:-4.74|P-value:5.28E-7 ID:SGTC_2908|Compound:7930301|FD-Score:-4.94|P-value:1.77E-7 ID:SGTC_2910|Compound:7948405|FD-Score:-5.53|P-value:6.18E-9 ID:SGTC_2914|Compound:7968218|FD-Score:-5.50|P-value:7.17E-9 ID:SGTC_2955|Compound:9076254|FD-Score:-3.34|P-value:2.84E-4 ID:SGTC_3206|Compound:9114350|FD-Score:3.33|P-value:3.11E-4

Top fitness defect scores for YCL074W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_883 0850-0245 4.72 24.6 µM 6.10E-7 cell wall 16 1.16E-6
2 SGTC_1289 0976-0073 4.25 69.1 µM 6.27E-6 9 1.06E-5
3 SGTC_693 4161-2696 4.23 114.0 µM 6.82E-6 5 1.14E-5
4 SGTC_1906 st060206 4.20 94.7 µM 8.03E-6 15 1.34E-5
5 SGTC_1889 st059080 3.94 5.2 µM 2.59E-5 16 4.06E-5
6 SGTC_359 0081-0058 3.80 15.9 µM 4.68E-5 60S ribosome export 51 7.12E-5
7 SGTC_873 0591-4978 3.75 488.0 µM 5.77E-5 21 8.67E-5
8 SGTC_392 N-ethylmaleimide 3.68 8.3 µM 7.89E-5 RNA pol III & RNase P/MRP 21 1.17E-4
9 SGTC_3206 9114350 3.33 49.5 µM 3.11E-4 40 4.29E-4
10 SGTC_1029 k015-0030 3.31 64.7 µM 3.43E-4 57 4.72E-4
11 SGTC_2762 leflunomide 2.92 42.1 µM 0.00134 84 0.00172
12 SGTC_2947 9072639 2.92 7.7 µM 0.00136 tubulin folding & SWR complex 106 0.00175
13 SGTC_701 4424-0219 2.91 185.0 µM 0.00141 calcium & mitochondrial duress 61 0.00180
14 SGTC_2889 9059656 2.83 52.0 µM 0.00183 47 0.00232
15 SGTC_1274 0865-0114 2.82 173.0 µM 0.00189 74 0.00238
16 SGTC_2805 7950783 2.82 58.4 µM 0.00189 84 0.00239
17 SGTC_810 3825-7150 2.80 143.0 µM 0.00204 60S ribosome export 52 0.00256
18 SGTC_3239 9133757 2.78 49.5 µM 0.00219 20 0.00275
19 SGTC_2979 9012552 2.76 45.5 µM 0.00231 31 0.00289
20 SGTC_2907 7721985 2.74 69.9 µM 0.00248 96 0.00309

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.176 1.01E-24 YPR167C MET16 hom 3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism
0.123 9.09E-13 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.121 1.70E-12 YDR300C PRO1 hom Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication
0.104 1.51E-9 YDL215C GDH2 hom NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
0.100 7.23E-9 YHR071W PCL5 hom Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
0.093 5.92E-8 YGR040W KSS1 hom Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
0.090 1.82E-7 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.085 8.10E-7 YKL030W_d YKL030W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
0.084 1.16E-6 YKL094W YJU3 hom Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
0.079 5.14E-6 YER066C-A_d YER066C-A_d hom Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W
0.079 5.25E-6 YDL104C QRI7 hom Highly conserved mitochondrial protein, essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification
0.077 7.63E-6 YLR241W_p YLR241W_p hom Putative protein of unknown function, may be involved in detoxification
0.076 9.68E-6 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.074 1.99E-5 YER147C SCC4 het Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
0.074 1.99E-5 YBR230C OM14 hom Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron