YCR020C-A / MAK31

Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR020C-A / MAK31

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.06|P-value:7.21E-8 ID:SGTC_72|Compound:0744-0168|FD-Score:3.02|P-value:8.10E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.76|P-value:1.16E-12 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.25|P-value:4.37E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-3.66|P-value:9.02E-5 ID:SGTC_385|Compound:1494-0393|FD-Score:2.96|P-value:9.93E-4 ID:SGTC_389|Compound:tpck|FD-Score:3.73|P-value:5.17E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:3.09|P-value:6.46E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:3.22|P-value:4.01E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.04|P-value:7.70E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.19|P-value:4.40E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.05|P-value:9.05E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.90|P-value:2.44E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:3.08|P-value:6.50E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.00|P-value:8.82E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.06|P-value:7.10E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-3.38|P-value:2.68E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.06|P-value:8.85E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.50|P-value:1.69E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:5.31|P-value:1.70E-8 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.92|P-value:2.92E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.79|P-value:3.21E-7 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.20|P-value:4.20E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:-4.07|P-value:1.54E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:-3.43|P-value:2.22E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:5.92|P-value:4.12E-10 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.40|P-value:1.96E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.30|P-value:2.96E-4 ID:SGTC_1784|Compound:st039334|FD-Score:-3.04|P-value:9.33E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.07|P-value:6.87E-4 ID:SGTC_1902|Compound:st060212|FD-Score:3.44|P-value:1.70E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.25|P-value:3.55E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.73|P-value:5.12E-5 ID:SGTC_2058|Compound:5236698|FD-Score:-3.03|P-value:9.63E-4 ID:SGTC_2193|Compound:5925765|FD-Score:4.08|P-value:1.07E-5 ID:SGTC_2264|Compound:7948757|FD-Score:-3.41|P-value:2.45E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.72|P-value:6.94E-5 ID:SGTC_2270|Compound:7924575|FD-Score:-6.38|P-value:2.84E-11 ID:SGTC_2279|Compound:7948423|FD-Score:-3.71|P-value:7.13E-5 ID:SGTC_2308|Compound:7584454|FD-Score:5.28|P-value:2.09E-8 ID:SGTC_2425|Compound:5628681|FD-Score:-4.05|P-value:1.65E-5 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.04|P-value:7.63E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.04|P-value:7.47E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.23|P-value:4.77E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.11|P-value:5.83E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.55|P-value:1.07E-4 ID:SGTC_2707|Compound:st078556|FD-Score:3.06|P-value:7.12E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.58|P-value:9.50E-5 ID:SGTC_2927|Compound:9011802|FD-Score:3.21|P-value:4.04E-4 ID:SGTC_2948|Compound:9070189|FD-Score:4.12|P-value:8.93E-6 ID:SGTC_2951|Compound:9072950|FD-Score:3.85|P-value:3.09E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.01|P-value:8.41E-4 ID:SGTC_3219|Compound:9131112|FD-Score:6.77|P-value:1.06E-12 ID:SGTC_3254|Compound:9136651|FD-Score:-3.06|P-value:8.86E-4 ID:SGTC_3347|Compound:9188721|FD-Score:-3.26|P-value:4.35E-4 ID:SGTC_3352|Compound:9151559|FD-Score:-3.48|P-value:1.86E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.06|P-value:7.21E-8 ID:SGTC_72|Compound:0744-0168|FD-Score:3.02|P-value:8.10E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.76|P-value:1.16E-12 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.25|P-value:4.37E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-3.66|P-value:9.02E-5 ID:SGTC_385|Compound:1494-0393|FD-Score:2.96|P-value:9.93E-4 ID:SGTC_389|Compound:tpck|FD-Score:3.73|P-value:5.17E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:3.09|P-value:6.46E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:3.22|P-value:4.01E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.04|P-value:7.70E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.19|P-value:4.40E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.05|P-value:9.05E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.90|P-value:2.44E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:3.08|P-value:6.50E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.00|P-value:8.82E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.06|P-value:7.10E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-3.38|P-value:2.68E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.06|P-value:8.85E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.50|P-value:1.69E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:5.31|P-value:1.70E-8 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.92|P-value:2.92E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.79|P-value:3.21E-7 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.20|P-value:4.20E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:-4.07|P-value:1.54E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:-3.43|P-value:2.22E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:5.92|P-value:4.12E-10 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.40|P-value:1.96E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.30|P-value:2.96E-4 ID:SGTC_1784|Compound:st039334|FD-Score:-3.04|P-value:9.33E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.07|P-value:6.87E-4 ID:SGTC_1902|Compound:st060212|FD-Score:3.44|P-value:1.70E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.25|P-value:3.55E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.73|P-value:5.12E-5 ID:SGTC_2058|Compound:5236698|FD-Score:-3.03|P-value:9.63E-4 ID:SGTC_2193|Compound:5925765|FD-Score:4.08|P-value:1.07E-5 ID:SGTC_2264|Compound:7948757|FD-Score:-3.41|P-value:2.45E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.72|P-value:6.94E-5 ID:SGTC_2270|Compound:7924575|FD-Score:-6.38|P-value:2.84E-11 ID:SGTC_2279|Compound:7948423|FD-Score:-3.71|P-value:7.13E-5 ID:SGTC_2308|Compound:7584454|FD-Score:5.28|P-value:2.09E-8 ID:SGTC_2425|Compound:5628681|FD-Score:-4.05|P-value:1.65E-5 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.04|P-value:7.63E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.04|P-value:7.47E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.23|P-value:4.77E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.11|P-value:5.83E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.55|P-value:1.07E-4 ID:SGTC_2707|Compound:st078556|FD-Score:3.06|P-value:7.12E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.58|P-value:9.50E-5 ID:SGTC_2927|Compound:9011802|FD-Score:3.21|P-value:4.04E-4 ID:SGTC_2948|Compound:9070189|FD-Score:4.12|P-value:8.93E-6 ID:SGTC_2951|Compound:9072950|FD-Score:3.85|P-value:3.09E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.01|P-value:8.41E-4 ID:SGTC_3219|Compound:9131112|FD-Score:6.77|P-value:1.06E-12 ID:SGTC_3254|Compound:9136651|FD-Score:-3.06|P-value:8.86E-4 ID:SGTC_3347|Compound:9188721|FD-Score:-3.26|P-value:4.35E-4 ID:SGTC_3352|Compound:9151559|FD-Score:-3.48|P-value:1.86E-4

Top fitness defect scores for YCR020C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3219 9131112 6.77 49.5 µM 1.06E-12 Golgi 11 6.25E-12
2 SGTC_138 0850-0259 6.76 40.9 µM 1.16E-12 cell wall 82 6.83E-12
3 SGTC_1426 4048-4480 5.92 71.7 µM 4.12E-10 60S ribosome export 2 1.65E-9
4 SGTC_1127 asiatic acid 5.31 681.4 nM 1.70E-8 6 5.36E-8
5 SGTC_2308 7584454 5.28 197.6 µM 2.09E-8 7 6.48E-8
6 SGTC_58 0957-0393 5.06 9.0 µM 7.21E-8 cell wall 279 2.06E-7
7 SGTC_1134 3477-0009 4.79 42.5 µM 3.21E-7 23 8.32E-7
8 SGTC_2948 9070189 4.12 9.4 µM 8.93E-6 plasma membrane duress 40 1.86E-5
9 SGTC_2193 5925765 4.08 200.0 µM 1.07E-5 5 2.21E-5
10 SGTC_700 3453-2283 3.90 142.0 µM 2.44E-5 amide catabolism 24 4.77E-5
11 SGTC_2951 9072950 3.85 58.1 µM 3.09E-5 ERG2 27 5.94E-5
12 SGTC_1940 st075990 3.73 51.1 µM 5.12E-5 60S ribosome export 27 9.52E-5
13 SGTC_389 tpck 3.73 16.7 µM 5.17E-5 32 9.61E-5
14 SGTC_2739 tacrine 3.58 100.9 µM 9.50E-5 heme requiring 28 1.70E-4
15 SGTC_2693 st077581 3.55 40.7 µM 1.07E-4 52 1.90E-4
16 SGTC_1902 st060212 3.44 70.5 µM 1.70E-4 22 2.93E-4
17 SGTC_1444 4112-3581 3.40 28.0 µM 1.96E-4 28 3.33E-4
18 SGTC_1531 st059297 3.30 52.4 µM 2.96E-4 43 4.91E-4
19 SGTC_1932 st074806 3.25 40.9 µM 3.55E-4 57 5.81E-4
20 SGTC_603 3794-0023 3.22 45.9 µM 4.01E-4 26 6.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.194 1.18E-29 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.188 4.13E-28 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.179 1.83E-25 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.177 4.68E-25 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.176 1.10E-24 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.172 8.38E-24 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.171 2.84E-23 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.163 2.21E-21 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.161 5.56E-21 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
0.160 1.40E-20 YML057C-A_d YML057C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W
0.155 1.69E-19 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.153 4.64E-19 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.152 8.61E-19 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.151 1.28E-18 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.150 1.98E-18 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress