YCR021C / HSP30

Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR021C / HSP30

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:2.85|P-value:7.63E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:-2.81|P-value:8.41E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.41|P-value:7.02E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:-6.14|P-value:3.81E-12 ID:SGTC_438|Compound:sphingosine|FD-Score:-4.81|P-value:4.05E-8 ID:SGTC_529|Compound:4076-0302|FD-Score:3.30|P-value:1.20E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.36|P-value:9.45E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:2.83|P-value:8.10E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.27|P-value:1.29E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.56|P-value:3.80E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.28|P-value:1.28E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.00|P-value:4.28E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.63|P-value:1.20E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.32|P-value:7.14E-7 ID:SGTC_1468|Compound:k284-1086|FD-Score:-2.92|P-value:5.58E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.65|P-value:2.27E-5 ID:SGTC_1518|Compound:st038567|FD-Score:-3.19|P-value:1.84E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.06|P-value:3.15E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.58|P-value:3.45E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-2.87|P-value:6.85E-4 ID:SGTC_1982|Compound:st072467|FD-Score:2.94|P-value:5.41E-4 ID:SGTC_2180|Compound:6301957|FD-Score:4.57|P-value:1.84E-7 ID:SGTC_2182|Compound:6325192|FD-Score:4.76|P-value:5.69E-8 ID:SGTC_2380|Compound:9035439|FD-Score:-3.26|P-value:1.34E-4 ID:SGTC_2382|Compound:9035899|FD-Score:-3.68|P-value:1.99E-5 ID:SGTC_2385|Compound:9074692|FD-Score:-4.59|P-value:1.56E-7 ID:SGTC_2388|Compound:9080168|FD-Score:-4.46|P-value:3.23E-7 ID:SGTC_2455|Compound:5377712|FD-Score:-3.55|P-value:3.73E-5 ID:SGTC_2468|Compound:5987765|FD-Score:2.81|P-value:8.82E-4 ID:SGTC_2474|Compound:5321570|FD-Score:-2.95|P-value:4.93E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.65|P-value:2.33E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:2.82|P-value:8.49E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.24|P-value:1.49E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.46|P-value:5.83E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.14|P-value:2.35E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:2.86|P-value:7.42E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-3.02|P-value:3.65E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.06|P-value:3.29E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:2.85|P-value:7.63E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:-2.81|P-value:8.41E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.41|P-value:7.02E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:-6.14|P-value:3.81E-12 ID:SGTC_438|Compound:sphingosine|FD-Score:-4.81|P-value:4.05E-8 ID:SGTC_529|Compound:4076-0302|FD-Score:3.30|P-value:1.20E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.36|P-value:9.45E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:2.83|P-value:8.10E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.27|P-value:1.29E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.56|P-value:3.80E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.28|P-value:1.28E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.00|P-value:4.28E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.63|P-value:1.20E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.32|P-value:7.14E-7 ID:SGTC_1468|Compound:k284-1086|FD-Score:-2.92|P-value:5.58E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.65|P-value:2.27E-5 ID:SGTC_1518|Compound:st038567|FD-Score:-3.19|P-value:1.84E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.06|P-value:3.15E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.58|P-value:3.45E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-2.87|P-value:6.85E-4 ID:SGTC_1982|Compound:st072467|FD-Score:2.94|P-value:5.41E-4 ID:SGTC_2180|Compound:6301957|FD-Score:4.57|P-value:1.84E-7 ID:SGTC_2182|Compound:6325192|FD-Score:4.76|P-value:5.69E-8 ID:SGTC_2380|Compound:9035439|FD-Score:-3.26|P-value:1.34E-4 ID:SGTC_2382|Compound:9035899|FD-Score:-3.68|P-value:1.99E-5 ID:SGTC_2385|Compound:9074692|FD-Score:-4.59|P-value:1.56E-7 ID:SGTC_2388|Compound:9080168|FD-Score:-4.46|P-value:3.23E-7 ID:SGTC_2455|Compound:5377712|FD-Score:-3.55|P-value:3.73E-5 ID:SGTC_2468|Compound:5987765|FD-Score:2.81|P-value:8.82E-4 ID:SGTC_2474|Compound:5321570|FD-Score:-2.95|P-value:4.93E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.65|P-value:2.33E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:2.82|P-value:8.49E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.24|P-value:1.49E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.46|P-value:5.83E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.14|P-value:2.35E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:2.86|P-value:7.42E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-3.02|P-value:3.65E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.06|P-value:3.29E-4

Top fitness defect scores for YCR021C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2182 6325192 4.76 200.0 µM 5.69E-8 Golgi 7 9.50E-7
2 SGTC_2180 6301957 4.57 200.0 µM 1.84E-7 RSC complex & mRNA processing 3 2.47E-6
3 SGTC_1701 st028638 3.58 40.4 µM 3.45E-5 22 1.74E-4
4 SGTC_999 4022-0066 3.56 22.7 µM 3.80E-5 Golgi 60 1.89E-4
5 SGTC_2546 rhodinyl acetate 3.46 100.0 µM 5.83E-5 21 2.68E-4
6 SGTC_551 k048-0028 3.36 34.9 µM 9.45E-5 39 3.97E-4
7 SGTC_529 4076-0302 3.30 30.3 µM 1.20E-4 mitochondrial processes 36 4.82E-4
8 SGTC_2563 tomatine 3.14 8.5 µM 2.35E-4 94 8.35E-4
9 SGTC_3143 9086658 3.06 49.5 µM 3.29E-4 103 0.00110
10 SGTC_1355 1499-0035 3.00 1.7 µM 4.28E-4 66 0.00136
11 SGTC_1982 st072467 2.94 71.9 µM 5.41E-4 92 0.00165
12 SGTC_2621 lithochol-11-enic acid 2.86 100.0 µM 7.42E-4 92 0.00214
13 SGTC_6 0844-0013 2.85 19.8 µM 7.63E-4 237 0.00219
14 SGTC_696 1560-0013 2.83 611.0 µM 8.10E-4 80 0.00230
15 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 2.82 3.7 µM 8.49E-4 244 0.00239
16 SGTC_2468 5987765 2.81 72.9 µM 8.82E-4 59 0.00247
17 SGTC_1491 4138-0063 2.74 26.5 µM 0.00115 43 0.00307
18 SGTC_101 0490-5701 2.72 117.5 µM 0.00124 73 0.00327
19 SGTC_2179 6298986 2.71 200.0 µM 0.00127 heme requiring 75 0.00332
20 SGTC_1510 1123-0200 2.70 71.5 µM 0.00132 132 0.00343

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.283 9.98E-63 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.225 1.17E-39 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.221 1.78E-38 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.219 1.18E-37 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.213 1.18E-35 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.210 8.65E-35 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.206 1.86E-33 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.203 1.30E-32 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.203 2.01E-32 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.200 1.70E-31 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.192 2.61E-29 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.188 3.59E-28 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.188 4.80E-28 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.187 1.20E-27 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.179 1.41E-25 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress