YCR022C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR022C / YCR022C

Click on Significant Values for Screen Details ID:SGTC_165|Compound:k038-0023|FD-Score:3.68|P-value:2.81E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:-3.24|P-value:1.75E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.19|P-value:2.15E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:2.97|P-value:5.83E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.54|P-value:4.52E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.03|P-value:4.54E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.18|P-value:2.21E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.55|P-value:4.32E-5 ID:SGTC_487|Compound:nimodipine|FD-Score:3.22|P-value:2.15E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:5.66|P-value:2.69E-10 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.37|P-value:9.71E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:3.95|P-value:7.67E-6 ID:SGTC_813|Compound:k007-0158|FD-Score:-2.80|P-value:9.65E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.47|P-value:7.12E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:2.93|P-value:6.71E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:2.98|P-value:5.47E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:2.87|P-value:8.54E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:-2.88|P-value:7.29E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.59|P-value:4.22E-5 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.08|P-value:3.71E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.67|P-value:2.87E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-5.28|P-value:2.81E-9 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:-2.86|P-value:7.78E-4 ID:SGTC_1647|Compound:st011722|FD-Score:2.94|P-value:6.57E-4 ID:SGTC_1721|Compound:st082152|FD-Score:2.95|P-value:6.32E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.33|P-value:1.35E-4 ID:SGTC_1776|Compound:st049249|FD-Score:2.98|P-value:5.61E-4 ID:SGTC_1853|Compound:st056710|FD-Score:4.45|P-value:5.45E-7 ID:SGTC_1864|Compound:st057645|FD-Score:3.29|P-value:1.56E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-3.06|P-value:3.60E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.96|P-value:6.06E-6 ID:SGTC_2068|Compound:5226020|FD-Score:3.15|P-value:2.82E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-2.86|P-value:7.88E-4 ID:SGTC_2137|Compound:5261020|FD-Score:-3.07|P-value:3.47E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-3.56|P-value:4.23E-5 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-2.97|P-value:5.12E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.63|P-value:2.99E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.55|P-value:5.16E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:3.19|P-value:2.43E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.46|P-value:6.55E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.55|P-value:2.57E-7 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.90|P-value:8.30E-6 ID:SGTC_2602|Compound:kawain|FD-Score:5.20|P-value:5.83E-9 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.16|P-value:2.74E-4 ID:SGTC_2646|Compound:retinol|FD-Score:-2.84|P-value:8.38E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.54|P-value:5.22E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.46|P-value:6.62E-5 ID:SGTC_2865|Compound:9030313|FD-Score:2.96|P-value:5.99E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.91|P-value:9.35E-6 ID:SGTC_2938|Compound:9059746|FD-Score:-3.48|P-value:5.95E-5 ID:SGTC_2989|Compound:9073649|FD-Score:2.85|P-value:9.12E-4 ID:SGTC_3089|Compound:9117425|FD-Score:4.78|P-value:8.06E-8 ID:SGTC_3094|Compound:9117742|FD-Score:-3.19|P-value:2.12E-4 ID:SGTC_3097|Compound:9117246|FD-Score:-3.68|P-value:2.40E-5 ID:SGTC_3153|Compound:9100258|FD-Score:2.83|P-value:9.83E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-3.63|P-value:3.08E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.50|P-value:6.37E-5 ID:SGTC_3228|Compound:9131799|FD-Score:3.26|P-value:1.82E-4 ID:SGTC_3241|Compound:9133421|FD-Score:3.16|P-value:2.71E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.46|P-value:7.51E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:3.68|P-value:2.81E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:-3.24|P-value:1.75E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.19|P-value:2.15E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:2.97|P-value:5.83E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.54|P-value:4.52E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.03|P-value:4.54E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.18|P-value:2.21E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.55|P-value:4.32E-5 ID:SGTC_487|Compound:nimodipine|FD-Score:3.22|P-value:2.15E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:5.66|P-value:2.69E-10 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.37|P-value:9.71E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:3.95|P-value:7.67E-6 ID:SGTC_813|Compound:k007-0158|FD-Score:-2.80|P-value:9.65E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.47|P-value:7.12E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:2.93|P-value:6.71E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:2.98|P-value:5.47E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:2.87|P-value:8.54E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:-2.88|P-value:7.29E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.59|P-value:4.22E-5 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.08|P-value:3.71E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.67|P-value:2.87E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-5.28|P-value:2.81E-9 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:-2.86|P-value:7.78E-4 ID:SGTC_1647|Compound:st011722|FD-Score:2.94|P-value:6.57E-4 ID:SGTC_1721|Compound:st082152|FD-Score:2.95|P-value:6.32E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.33|P-value:1.35E-4 ID:SGTC_1776|Compound:st049249|FD-Score:2.98|P-value:5.61E-4 ID:SGTC_1853|Compound:st056710|FD-Score:4.45|P-value:5.45E-7 ID:SGTC_1864|Compound:st057645|FD-Score:3.29|P-value:1.56E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-3.06|P-value:3.60E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.96|P-value:6.06E-6 ID:SGTC_2068|Compound:5226020|FD-Score:3.15|P-value:2.82E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-2.86|P-value:7.88E-4 ID:SGTC_2137|Compound:5261020|FD-Score:-3.07|P-value:3.47E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-3.56|P-value:4.23E-5 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-2.97|P-value:5.12E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.63|P-value:2.99E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.55|P-value:5.16E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:3.19|P-value:2.43E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.46|P-value:6.55E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.55|P-value:2.57E-7 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.90|P-value:8.30E-6 ID:SGTC_2602|Compound:kawain|FD-Score:5.20|P-value:5.83E-9 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.16|P-value:2.74E-4 ID:SGTC_2646|Compound:retinol|FD-Score:-2.84|P-value:8.38E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.54|P-value:5.22E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.46|P-value:6.62E-5 ID:SGTC_2865|Compound:9030313|FD-Score:2.96|P-value:5.99E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.91|P-value:9.35E-6 ID:SGTC_2938|Compound:9059746|FD-Score:-3.48|P-value:5.95E-5 ID:SGTC_2989|Compound:9073649|FD-Score:2.85|P-value:9.12E-4 ID:SGTC_3089|Compound:9117425|FD-Score:4.78|P-value:8.06E-8 ID:SGTC_3094|Compound:9117742|FD-Score:-3.19|P-value:2.12E-4 ID:SGTC_3097|Compound:9117246|FD-Score:-3.68|P-value:2.40E-5 ID:SGTC_3153|Compound:9100258|FD-Score:2.83|P-value:9.83E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-3.63|P-value:3.08E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.50|P-value:6.37E-5 ID:SGTC_3228|Compound:9131799|FD-Score:3.26|P-value:1.82E-4 ID:SGTC_3241|Compound:9133421|FD-Score:3.16|P-value:2.71E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.46|P-value:7.51E-5

Top fitness defect scores for YCR022C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_592 k241-0073 5.66 46.5 µM 2.69E-10 7 7.59E-9
2 SGTC_2602 kawain 5.20 100.0 µM 5.83E-9 5 9.86E-8
3 SGTC_3089 9117425 4.78 49.5 µM 8.06E-8 9 8.81E-7
4 SGTC_1853 st056710 4.45 91.2 µM 5.45E-7 amide catabolism 17 4.35E-6
5 SGTC_787 4152-0075 3.95 138.0 µM 7.67E-6 23 3.96E-5
6 SGTC_2871 9038510 3.91 13.0 µM 9.35E-6 16 4.68E-5
7 SGTC_165 k038-0023 3.68 64.4 µM 2.81E-5 ubiquinone biosynthesis & proteasome 94 1.17E-4
8 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 3.67 85.4 µM 2.87E-5 30 1.20E-4
9 SGTC_1534 6-azauridine 3.59 81.6 µM 4.22E-5 RNA pol III & RNase P/MRP 37 1.65E-4
10 SGTC_2531 methyl deoxycholate 3.55 70.1 µM 5.16E-5 37 1.96E-4
11 SGTC_2729 fluphenazine 3.54 10.7 µM 5.22E-5 26 1.98E-4
12 SGTC_3203 9113543 3.50 49.5 µM 6.37E-5 45 2.34E-4
13 SGTC_814 3342-0569 3.47 96.0 µM 7.12E-5 34 2.56E-4
14 SGTC_3310 9130229 3.46 44.1 µM 7.51E-5 Golgi 43 2.68E-4
15 SGTC_1730 st033808 3.33 45.1 µM 1.35E-4 71 4.40E-4
16 SGTC_1864 st057645 3.29 30.4 µM 1.56E-4 amide catabolism 24 4.96E-4
17 SGTC_3228 9131799 3.26 49.5 µM 1.82E-4 amide catabolism 22 5.63E-4
18 SGTC_487 nimodipine 3.22 119.0 µM 2.15E-4 20 6.48E-4
19 SGTC_2533 agelasine 3.19 13.7 µM 2.43E-4 ERG2 86 7.19E-4
20 SGTC_3241 9133421 3.16 49.5 µM 2.71E-4 PDR1 7 7.87E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.098 1.11E-8 YNR051C BRE5 hom Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A
0.096 2.67E-8 YFR055W_p IRC7_p hom Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner
0.089 2.33E-7 YMR095C SNO1 hom Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
0.087 4.18E-7 YDR068W DOS2 hom Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.087 4.28E-7 YGL110C CUE3 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
0.085 8.33E-7 YLR415C_p YLR415C_p hom Putative protein of unknown function; YLR415C is not an essential gene
0.081 2.82E-6 YER042W MXR1 hom Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan
0.079 4.31E-6 YOL042W NGL1 hom Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.079 4.27E-6 YFR012W DCV1 hom Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication
0.079 5.01E-6 YOR266W PNT1 hom Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine
0.076 1.19E-5 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.074 1.94E-5 YMR092C AIP1 hom Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress
0.074 2.02E-5 YLR190W MMR1 hom Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
0.073 2.04E-5 YER104W RTT105 het Protein with a role in regulation of Ty1 transposition
0.072 2.70E-5 YKR096W ESL2 hom Protein of unknown function that interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain