YCR027C / RHB1

Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR027C / RHB1

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:4.36|P-value:8.41E-6 ID:SGTC_77|Compound:0828-0286|FD-Score:3.55|P-value:2.29E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:4.04|P-value:3.37E-5 ID:SGTC_336|Compound:4111-0029|FD-Score:3.13|P-value:9.93E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.43|P-value:3.54E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.88|P-value:6.43E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.63|P-value:1.63E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:3.86|P-value:7.01E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.64|P-value:1.56E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.28|P-value:5.90E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.52|P-value:2.47E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.22|P-value:7.31E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.16|P-value:9.00E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:-5.85|P-value:3.57E-9 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.33|P-value:5.09E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.02|P-value:3.54E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:-4.03|P-value:3.36E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:3.35|P-value:4.72E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.29|P-value:5.86E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.54|P-value:2.36E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:-4.33|P-value:9.37E-6 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.35|P-value:4.68E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:-3.62|P-value:1.69E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.28|P-value:5.92E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:-4.43|P-value:6.02E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.43|P-value:3.43E-4 ID:SGTC_1652|Compound:st011932|FD-Score:-3.47|P-value:3.04E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.11|P-value:2.43E-5 ID:SGTC_1806|Compound:st050005|FD-Score:3.47|P-value:3.10E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.62|P-value:1.70E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.43|P-value:6.12E-6 ID:SGTC_2146|Compound:5545642|FD-Score:3.23|P-value:7.18E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.29|P-value:5.70E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.33|P-value:5.02E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.83|P-value:7.90E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.84|P-value:8.82E-7 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.16|P-value:9.16E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.32|P-value:9.53E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.21|P-value:7.53E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.69|P-value:1.35E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.99|P-value:3.99E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.32|P-value:5.21E-4 ID:SGTC_2876|Compound:9059903|FD-Score:-4.11|P-value:2.41E-5 ID:SGTC_2933|Compound:9026794|FD-Score:3.64|P-value:1.62E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.64|P-value:1.64E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-3.83|P-value:7.55E-5 ID:SGTC_3107|Compound:9121808|FD-Score:-3.47|P-value:2.95E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.40|P-value:3.82E-4 ID:SGTC_3349|Compound:9149703|FD-Score:4.61|P-value:2.67E-6 ID:SGTC_17|Compound:0960-0276|FD-Score:4.36|P-value:8.41E-6 ID:SGTC_77|Compound:0828-0286|FD-Score:3.55|P-value:2.29E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:4.04|P-value:3.37E-5 ID:SGTC_336|Compound:4111-0029|FD-Score:3.13|P-value:9.93E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.43|P-value:3.54E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.88|P-value:6.43E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.63|P-value:1.63E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:3.86|P-value:7.01E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.64|P-value:1.56E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.28|P-value:5.90E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.52|P-value:2.47E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.22|P-value:7.31E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.16|P-value:9.00E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:-5.85|P-value:3.57E-9 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.33|P-value:5.09E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.02|P-value:3.54E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:-4.03|P-value:3.36E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:3.35|P-value:4.72E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.29|P-value:5.86E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.54|P-value:2.36E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:-4.33|P-value:9.37E-6 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.35|P-value:4.68E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:-3.62|P-value:1.69E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.28|P-value:5.92E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:-4.43|P-value:6.02E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.43|P-value:3.43E-4 ID:SGTC_1652|Compound:st011932|FD-Score:-3.47|P-value:3.04E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.11|P-value:2.43E-5 ID:SGTC_1806|Compound:st050005|FD-Score:3.47|P-value:3.10E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.62|P-value:1.70E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.43|P-value:6.12E-6 ID:SGTC_2146|Compound:5545642|FD-Score:3.23|P-value:7.18E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.29|P-value:5.70E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.33|P-value:5.02E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.83|P-value:7.90E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.84|P-value:8.82E-7 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.16|P-value:9.16E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.32|P-value:9.53E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.21|P-value:7.53E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.69|P-value:1.35E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.99|P-value:3.99E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.32|P-value:5.21E-4 ID:SGTC_2876|Compound:9059903|FD-Score:-4.11|P-value:2.41E-5 ID:SGTC_2933|Compound:9026794|FD-Score:3.64|P-value:1.62E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.64|P-value:1.64E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-3.83|P-value:7.55E-5 ID:SGTC_3107|Compound:9121808|FD-Score:-3.47|P-value:2.95E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.40|P-value:3.82E-4 ID:SGTC_3349|Compound:9149703|FD-Score:4.61|P-value:2.67E-6

Top fitness defect scores for YCR027C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2504 purpurogallin 4.84 52.3 µM 8.82E-7 RPP1 & pyrimidine depletion 8 6.55E-7
2 SGTC_3349 9149703 4.61 23.0 µM 2.67E-6 8 2.04E-6
3 SGTC_2016 5121758 4.43 140.0 µM 6.12E-6 redox potentiating 33 4.75E-6
4 SGTC_17 0960-0276 4.36 49.8 µM 8.41E-6 20 6.59E-6
5 SGTC_1801 st050089 4.11 28.4 µM 2.43E-5 NEO1-PIK1 110 1.95E-5
6 SGTC_323 4013-0906 4.04 34.3 µM 3.37E-5 ERG2 13 2.72E-5
7 SGTC_1110 3-hydroxy-3'-methoxyflavone 4.02 1.2 µM 3.54E-5 iron homeostasis 40 2.86E-5
8 SGTC_2856 9022925 3.99 19.5 µM 3.99E-5 17 3.24E-5
9 SGTC_550 4123-0385 3.88 25.7 µM 6.43E-5 TSC3-RPN4 28 5.28E-5
10 SGTC_843 0310-0051 3.86 143.0 µM 7.01E-5 12 5.77E-5
11 SGTC_2495 cafestol 3.83 54.5 µM 7.90E-5 Golgi 26 6.51E-5
12 SGTC_2797 7859098 3.69 81.8 µM 1.35E-4 33 1.12E-4
13 SGTC_2933 9026794 3.64 32.5 µM 1.62E-4 33 1.36E-4
14 SGTC_2955 9076254 3.64 12.2 µM 1.64E-4 21 1.38E-4
15 SGTC_77 0828-0286 3.55 12.5 µM 2.29E-4 TSC3-RPN4 55 1.94E-4
16 SGTC_1250 0485-0349 3.54 40.2 µM 2.36E-4 47 2.00E-4
17 SGTC_1806 st050005 3.47 60.3 µM 3.10E-4 28 2.64E-4
18 SGTC_549 1661-1316 3.43 519.0 µM 3.54E-4 29 3.02E-4
19 SGTC_1298 1079-1278 3.35 263.0 µM 4.68E-4 DNA damage response 41 4.02E-4
20 SGTC_1123 mangostin 3.35 811.3 nM 4.72E-4 mitochondrial response to ROS 61 4.05E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 2.13E-13 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.109 2.40E-10 YGR121C MEP1 hom Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
0.099 9.41E-9 YOR249C APC5 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress
0.088 3.22E-7 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.085 9.29E-7 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.078 6.22E-6 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.077 8.16E-6 YAR014C BUD14 hom Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress
0.075 1.53E-5 YJR039W_p YJR039W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.074 1.92E-5 YDR446W ECM11 hom Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
0.074 1.92E-5 YDR464W SPP41 het Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
0.074 1.96E-5 YMR306W FKS3 hom Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.073 2.24E-5 YOR253W NAT5 hom Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
0.070 4.77E-5 YKL147C_d YKL147C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
0.070 5.45E-5 YPL250C ICY2 hom Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
0.068 8.18E-5 YPL015C HST2 hom Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export