YCR060W / TAH1

Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR060W / TAH1

Click on Significant Values for Screen Details ID:SGTC_74|Compound:000s-0487|FD-Score:-3.49|P-value:6.82E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.11|P-value:3.42E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-2.91|P-value:7.34E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:4.29|P-value:1.85E-6 ID:SGTC_401|Compound:neomycin|FD-Score:-3.12|P-value:3.16E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.20|P-value:2.26E-6 ID:SGTC_438|Compound:sphingosine|FD-Score:2.96|P-value:7.39E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-2.87|P-value:8.38E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.32|P-value:1.77E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.59|P-value:5.53E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:3.09|P-value:4.49E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:2.99|P-value:6.62E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.36|P-value:1.49E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:4.10|P-value:5.04E-6 ID:SGTC_1205|Compound:4161-2785|FD-Score:6.29|P-value:5.27E-12 ID:SGTC_1368|Compound:1852-0141|FD-Score:-4.53|P-value:3.84E-7 ID:SGTC_1377|Compound:2944-0135|FD-Score:5.09|P-value:1.97E-8 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.33|P-value:1.36E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.33|P-value:1.66E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.01|P-value:6.01E-4 ID:SGTC_1812|Compound:st052057|FD-Score:4.12|P-value:4.42E-6 ID:SGTC_2032|Compound:5185112|FD-Score:2.99|P-value:6.64E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.02|P-value:7.54E-6 ID:SGTC_2175|Compound:5807670|FD-Score:3.37|P-value:1.42E-4 ID:SGTC_2186|Compound:6124449|FD-Score:5.01|P-value:3.23E-8 ID:SGTC_2276|Compound:7947513|FD-Score:-3.56|P-value:4.99E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.25|P-value:2.33E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-3.31|P-value:1.48E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.90|P-value:1.31E-5 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.22|P-value:2.64E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.47|P-value:7.49E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-2.97|P-value:5.82E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.15|P-value:3.46E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.00|P-value:5.15E-4 ID:SGTC_3021|Compound:9087658|FD-Score:2.99|P-value:6.61E-4 ID:SGTC_3023|Compound:9089636|FD-Score:-3.71|P-value:2.49E-5 ID:SGTC_3025|Compound:9087895|FD-Score:3.11|P-value:4.13E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.58|P-value:4.62E-5 ID:SGTC_3138|Compound:9097216|FD-Score:-3.67|P-value:3.04E-5 ID:SGTC_3188|Compound:9110789|FD-Score:4.19|P-value:3.09E-6 ID:SGTC_3202|Compound:9113761|FD-Score:-3.60|P-value:4.26E-5 ID:SGTC_3206|Compound:9114350|FD-Score:-3.44|P-value:8.36E-5 ID:SGTC_3272|Compound:9137413|FD-Score:-2.88|P-value:8.13E-4 ID:SGTC_3336|Compound:9143619|FD-Score:4.92|P-value:5.59E-8 ID:SGTC_3345|Compound:9148410|FD-Score:3.44|P-value:1.06E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.49|P-value:6.82E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.11|P-value:3.42E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-2.91|P-value:7.34E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:4.29|P-value:1.85E-6 ID:SGTC_401|Compound:neomycin|FD-Score:-3.12|P-value:3.16E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.20|P-value:2.26E-6 ID:SGTC_438|Compound:sphingosine|FD-Score:2.96|P-value:7.39E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-2.87|P-value:8.38E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.32|P-value:1.77E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.59|P-value:5.53E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:3.09|P-value:4.49E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:2.99|P-value:6.62E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.36|P-value:1.49E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:4.10|P-value:5.04E-6 ID:SGTC_1205|Compound:4161-2785|FD-Score:6.29|P-value:5.27E-12 ID:SGTC_1368|Compound:1852-0141|FD-Score:-4.53|P-value:3.84E-7 ID:SGTC_1377|Compound:2944-0135|FD-Score:5.09|P-value:1.97E-8 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.33|P-value:1.36E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.33|P-value:1.66E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.01|P-value:6.01E-4 ID:SGTC_1812|Compound:st052057|FD-Score:4.12|P-value:4.42E-6 ID:SGTC_2032|Compound:5185112|FD-Score:2.99|P-value:6.64E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.02|P-value:7.54E-6 ID:SGTC_2175|Compound:5807670|FD-Score:3.37|P-value:1.42E-4 ID:SGTC_2186|Compound:6124449|FD-Score:5.01|P-value:3.23E-8 ID:SGTC_2276|Compound:7947513|FD-Score:-3.56|P-value:4.99E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.25|P-value:2.33E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-3.31|P-value:1.48E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.90|P-value:1.31E-5 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.22|P-value:2.64E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.47|P-value:7.49E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-2.97|P-value:5.82E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.15|P-value:3.46E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.00|P-value:5.15E-4 ID:SGTC_3021|Compound:9087658|FD-Score:2.99|P-value:6.61E-4 ID:SGTC_3023|Compound:9089636|FD-Score:-3.71|P-value:2.49E-5 ID:SGTC_3025|Compound:9087895|FD-Score:3.11|P-value:4.13E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.58|P-value:4.62E-5 ID:SGTC_3138|Compound:9097216|FD-Score:-3.67|P-value:3.04E-5 ID:SGTC_3188|Compound:9110789|FD-Score:4.19|P-value:3.09E-6 ID:SGTC_3202|Compound:9113761|FD-Score:-3.60|P-value:4.26E-5 ID:SGTC_3206|Compound:9114350|FD-Score:-3.44|P-value:8.36E-5 ID:SGTC_3272|Compound:9137413|FD-Score:-2.88|P-value:8.13E-4 ID:SGTC_3336|Compound:9143619|FD-Score:4.92|P-value:5.59E-8 ID:SGTC_3345|Compound:9148410|FD-Score:3.44|P-value:1.06E-4

Top fitness defect scores for YCR060W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1205 4161-2785 6.29 76.0 µM 5.27E-12 7 1.54E-10
2 SGTC_1377 2944-0135 5.09 198.0 µM 1.97E-8 calcium & mitochondrial duress 18 1.78E-7
3 SGTC_2186 6124449 5.01 200.0 µM 3.23E-8 RSC complex & mRNA processing 9 2.72E-7
4 SGTC_3336 9143619 4.92 71.4 µM 5.59E-8 6 4.37E-7
5 SGTC_316 k060-0003 4.29 58.6 µM 1.85E-6 11 8.82E-6
6 SGTC_3188 9110789 4.19 49.5 µM 3.09E-6 iron homeostasis 17 1.37E-5
7 SGTC_1812 st052057 4.12 4.3 µM 4.42E-6 calcium & mitochondrial duress 20 1.87E-5
8 SGTC_1200 1643-0193 4.10 18.4 µM 5.04E-6 14 2.09E-5
9 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 4.02 49.5 µM 7.54E-6 19 2.96E-5
10 SGTC_2763 lisinopril 3.90 49.3 µM 1.31E-5 13 4.76E-5
11 SGTC_916 4466-0038 3.59 42.0 nM 5.53E-5 cell wall 89 1.65E-4
12 SGTC_3345 9148410 3.44 3.6 µM 1.06E-4 16 2.88E-4
13 SGTC_2175 5807670 3.37 165.3 µM 1.42E-4 36 3.73E-4
14 SGTC_1198 1612-1005 3.36 86.7 µM 1.49E-4 28 3.88E-4
15 SGTC_1574 spiramycin 3.33 23.7 µM 1.66E-4 56 4.28E-4
16 SGTC_910 3454-3003 3.32 490.0 µM 1.77E-4 36 4.51E-4
17 SGTC_2408 sulbentine 3.25 18.4 µM 2.33E-4 79 5.71E-4
18 SGTC_2764 methyldopa 3.22 94.7 µM 2.64E-4 46 6.36E-4
19 SGTC_2789 5281112 3.15 71.4 µM 3.46E-4 75 8.04E-4
20 SGTC_3025 9087895 3.11 49.5 µM 4.13E-4 PDR1 62 9.39E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 8.22E-16 YBR261C TAE1 hom AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm
0.125 3.80E-13 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.114 3.19E-11 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.114 3.39E-11 YDL230W PTP1 hom Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
0.114 3.87E-11 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.113 4.52E-11 YLR189C ATG26 hom UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
0.108 3.10E-10 YIL092W_p YIL092W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
0.106 7.21E-10 YJR153W PGU1 hom Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
0.100 6.76E-9 YML058W-A HUG1 hom Protein involved in the Mec1p-mediated checkpoint pathway; transcription is induced by DNA damage; protein abundance increases in response to DNA replication stress
0.099 1.02E-8 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.099 1.02E-8 YCL038C ATG22 hom Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation
0.097 1.82E-8 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.095 3.28E-8 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.094 4.98E-8 YBR165W UBS1 hom Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
0.092 8.12E-8 YOR079C ATX2 hom Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation