YCR088W / ABP1

Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR088W / ABP1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:-3.12|P-value:4.34E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.53|P-value:6.98E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:3.28|P-value:2.35E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:3.43|P-value:1.30E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:-3.47|P-value:1.07E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.43|P-value:1.24E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.23|P-value:2.94E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:2.93|P-value:9.16E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.23|P-value:2.91E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.23|P-value:2.90E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-2.98|P-value:7.38E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:-3.13|P-value:4.20E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:-3.28|P-value:2.30E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.68|P-value:4.30E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:2.92|P-value:9.21E-4 ID:SGTC_1615|Compound:st002656|FD-Score:-2.94|P-value:8.34E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-2.97|P-value:7.57E-4 ID:SGTC_1766|Compound:st045414|FD-Score:4.10|P-value:6.32E-6 ID:SGTC_1953|Compound:st076800|FD-Score:3.43|P-value:1.28E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.02|P-value:6.24E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.23|P-value:2.93E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-2.98|P-value:7.41E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.70|P-value:3.87E-5 ID:SGTC_2305|Compound:7443522|FD-Score:-3.04|P-value:5.90E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-3.82|P-value:2.22E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.65|P-value:4.93E-5 ID:SGTC_2399|Compound:5884133|FD-Score:3.59|P-value:6.67E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-2.96|P-value:7.92E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-2.95|P-value:8.26E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.14|P-value:4.07E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:2.95|P-value:8.29E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:10.50|P-value:1.71E-29 ID:SGTC_2570|Compound:licareol|FD-Score:-4.61|P-value:4.28E-7 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.61|P-value:5.71E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.07|P-value:2.12E-22 ID:SGTC_2601|Compound:securinine|FD-Score:2.94|P-value:8.58E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:4.23|P-value:3.32E-6 ID:SGTC_2620|Compound:irigenin|FD-Score:3.64|P-value:5.18E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.87|P-value:1.89E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.62|P-value:4.31E-7 ID:SGTC_2693|Compound:st077581|FD-Score:-4.34|P-value:1.82E-6 ID:SGTC_2694|Compound:st077685|FD-Score:-3.41|P-value:1.35E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.43|P-value:1.27E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.44|P-value:1.21E-4 ID:SGTC_2912|Compound:7964298|FD-Score:2.93|P-value:9.15E-4 ID:SGTC_2961|Compound:9083290|FD-Score:3.74|P-value:3.31E-5 ID:SGTC_3036|Compound:9090181|FD-Score:3.52|P-value:8.97E-5 ID:SGTC_3103|Compound:9120822|FD-Score:2.92|P-value:9.24E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:-3.12|P-value:4.34E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.53|P-value:6.98E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:3.28|P-value:2.35E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:3.43|P-value:1.30E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:-3.47|P-value:1.07E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.43|P-value:1.24E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.23|P-value:2.94E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:2.93|P-value:9.16E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.23|P-value:2.91E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.23|P-value:2.90E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-2.98|P-value:7.38E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:-3.13|P-value:4.20E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:-3.28|P-value:2.30E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.68|P-value:4.30E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:2.92|P-value:9.21E-4 ID:SGTC_1615|Compound:st002656|FD-Score:-2.94|P-value:8.34E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-2.97|P-value:7.57E-4 ID:SGTC_1766|Compound:st045414|FD-Score:4.10|P-value:6.32E-6 ID:SGTC_1953|Compound:st076800|FD-Score:3.43|P-value:1.28E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.02|P-value:6.24E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.23|P-value:2.93E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-2.98|P-value:7.41E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.70|P-value:3.87E-5 ID:SGTC_2305|Compound:7443522|FD-Score:-3.04|P-value:5.90E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-3.82|P-value:2.22E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.65|P-value:4.93E-5 ID:SGTC_2399|Compound:5884133|FD-Score:3.59|P-value:6.67E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-2.96|P-value:7.92E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-2.95|P-value:8.26E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.14|P-value:4.07E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:2.95|P-value:8.29E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:10.50|P-value:1.71E-29 ID:SGTC_2570|Compound:licareol|FD-Score:-4.61|P-value:4.28E-7 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.61|P-value:5.71E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.07|P-value:2.12E-22 ID:SGTC_2601|Compound:securinine|FD-Score:2.94|P-value:8.58E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:4.23|P-value:3.32E-6 ID:SGTC_2620|Compound:irigenin|FD-Score:3.64|P-value:5.18E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.87|P-value:1.89E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.62|P-value:4.31E-7 ID:SGTC_2693|Compound:st077581|FD-Score:-4.34|P-value:1.82E-6 ID:SGTC_2694|Compound:st077685|FD-Score:-3.41|P-value:1.35E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.43|P-value:1.27E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.44|P-value:1.21E-4 ID:SGTC_2912|Compound:7964298|FD-Score:2.93|P-value:9.15E-4 ID:SGTC_2961|Compound:9083290|FD-Score:3.74|P-value:3.31E-5 ID:SGTC_3036|Compound:9090181|FD-Score:3.52|P-value:8.97E-5 ID:SGTC_3103|Compound:9120822|FD-Score:2.92|P-value:9.24E-4

Top fitness defect scores for YCR088W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2564 betulinic acid 10.50 100.0 µM 1.71E-29 1 3.49E-26
2 SGTC_2582 agaric acid 9.07 100.0 µM 2.12E-22 redox potentiating 84 6.16E-20
3 SGTC_2688 kanamycin b 4.62 96.7 µM 4.31E-7 calcium & mitochondrial duress 282 1.94E-6
4 SGTC_138 0850-0259 4.53 40.9 µM 6.98E-7 cell wall 165 2.97E-6
5 SGTC_2619 obliquin 4.23 87.9 µM 3.32E-6 cell wall 132 1.18E-5
6 SGTC_1766 st045414 4.10 44.8 µM 6.32E-6 RPP1 & pyrimidine depletion 21 2.09E-5
7 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 3.87 100.0 µM 1.89E-5 37 5.51E-5
8 SGTC_2961 9083290 3.74 32.5 µM 3.31E-5 25 9.04E-5
9 SGTC_2310 7668677 3.65 200.0 µM 4.93E-5 44 1.29E-4
10 SGTC_2620 irigenin 3.64 100.0 µM 5.18E-5 47 1.35E-4
11 SGTC_2399 5884133 3.59 200.0 µM 6.67E-5 cell wall signaling 87 1.68E-4
12 SGTC_3036 9090181 3.52 49.5 µM 8.97E-5 11 2.19E-4
13 SGTC_1953 st076800 3.43 12.1 µM 1.28E-4 65 3.00E-4
14 SGTC_185 k048-0037 3.43 25.5 µM 1.30E-4 RSC & ERG11 20 3.04E-4
15 SGTC_158 k038-0087 3.28 26.4 µM 2.35E-4 ubiquinone biosynthesis & proteasome 188 5.13E-4
16 SGTC_898 1000-0849 3.23 28.3 µM 2.90E-4 20 6.19E-4
17 SGTC_593 1203-0218 3.23 61.7 µM 2.91E-4 30 6.22E-4
18 SGTC_2208 7283366 3.23 200.0 µM 2.93E-4 22 6.25E-4
19 SGTC_366 0181-0206 3.23 4.3 µM 2.94E-4 Golgi 75 6.26E-4
20 SGTC_2546 rhodinyl acetate 3.14 100.0 µM 4.07E-4 36 8.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.262 1.66E-53 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.235 1.97E-43 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.224 1.62E-39 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.213 1.21E-35 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.204 9.48E-33 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.203 1.18E-32 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.202 2.26E-32 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.202 2.28E-32 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.201 6.79E-32 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.192 3.29E-29 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.192 3.66E-29 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.186 1.64E-27 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.186 1.81E-27 YBR070C ALG14 het Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases
0.181 5.10E-26 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.174 2.72E-24 YOR051C ETT1 hom Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough