YDL010W / GRX6

Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL010W / GRX6

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:-3.37|P-value:3.12E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.21|P-value:5.38E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.45|P-value:2.29E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-7.82|P-value:9.37E-16 ID:SGTC_52|Compound:0329-0193|FD-Score:4.68|P-value:9.95E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.14|P-value:7.06E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.77|P-value:6.20E-5 ID:SGTC_287|Compound:k060-0039|FD-Score:4.44|P-value:3.10E-6 ID:SGTC_296|Compound:1222-0039|FD-Score:-3.29|P-value:4.14E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:4.14|P-value:1.29E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:3.80|P-value:5.58E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:-5.09|P-value:1.20E-7 ID:SGTC_717|Compound:1532-0246|FD-Score:3.08|P-value:8.65E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.54|P-value:1.62E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.41|P-value:2.62E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.18|P-value:6.16E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:4.27|P-value:7.19E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:5.81|P-value:1.73E-9 ID:SGTC_1351|Compound:1496-0003|FD-Score:5.41|P-value:1.87E-8 ID:SGTC_1356|Compound:1502-0781|FD-Score:-4.88|P-value:3.60E-7 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.07|P-value:8.99E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:-3.31|P-value:3.88E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.36|P-value:3.17E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:4.23|P-value:8.47E-6 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.79|P-value:5.89E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.59|P-value:1.31E-4 ID:SGTC_1646|Compound:st011709|FD-Score:-3.62|P-value:1.20E-4 ID:SGTC_1649|Compound:st011737|FD-Score:3.93|P-value:3.20E-5 ID:SGTC_1836|Compound:st055642|FD-Score:3.16|P-value:6.55E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-6.85|P-value:1.77E-12 ID:SGTC_1852|Compound:st056254|FD-Score:-3.55|P-value:1.58E-4 ID:SGTC_1867|Compound:st057372|FD-Score:-3.87|P-value:4.30E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:-6.45|P-value:2.86E-11 ID:SGTC_1873|Compound:rapamycin|FD-Score:-8.06|P-value:1.27E-16 ID:SGTC_1874|Compound:staurosporine|FD-Score:-5.00|P-value:1.91E-7 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-6.11|P-value:2.63E-10 ID:SGTC_1916|Compound:st067606|FD-Score:-5.67|P-value:4.26E-9 ID:SGTC_1925|Compound:st057770|FD-Score:-3.26|P-value:4.62E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-4.29|P-value:6.67E-6 ID:SGTC_1984|Compound:st072354|FD-Score:-4.32|P-value:5.69E-6 ID:SGTC_1986|Compound:st071812|FD-Score:-3.31|P-value:3.92E-4 ID:SGTC_1987|Compound:st072290|FD-Score:-3.27|P-value:4.45E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.39|P-value:2.92E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-3.11|P-value:7.87E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.29|P-value:4.07E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.57|P-value:1.39E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.71|P-value:8.16E-5 ID:SGTC_2790|Compound:5423970|FD-Score:-3.84|P-value:4.89E-5 ID:SGTC_2848|Compound:9016370|FD-Score:-4.25|P-value:8.07E-6 ID:SGTC_2857|Compound:9024691|FD-Score:3.13|P-value:7.35E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.42|P-value:2.57E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-5.25|P-value:4.83E-8 ID:SGTC_2902|Compound:5787006|FD-Score:-3.57|P-value:1.44E-4 ID:SGTC_2914|Compound:7968218|FD-Score:-3.55|P-value:1.54E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.75|P-value:6.85E-5 ID:SGTC_3028|Compound:9087778|FD-Score:3.22|P-value:5.36E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.74|P-value:7.19E-5 ID:SGTC_3296|Compound:9122258|FD-Score:3.46|P-value:2.17E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.65|P-value:1.01E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:-3.37|P-value:3.12E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.21|P-value:5.38E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.45|P-value:2.29E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-7.82|P-value:9.37E-16 ID:SGTC_52|Compound:0329-0193|FD-Score:4.68|P-value:9.95E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.14|P-value:7.06E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.77|P-value:6.20E-5 ID:SGTC_287|Compound:k060-0039|FD-Score:4.44|P-value:3.10E-6 ID:SGTC_296|Compound:1222-0039|FD-Score:-3.29|P-value:4.14E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:4.14|P-value:1.29E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:3.80|P-value:5.58E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:-5.09|P-value:1.20E-7 ID:SGTC_717|Compound:1532-0246|FD-Score:3.08|P-value:8.65E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.54|P-value:1.62E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.41|P-value:2.62E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.18|P-value:6.16E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:4.27|P-value:7.19E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:5.81|P-value:1.73E-9 ID:SGTC_1351|Compound:1496-0003|FD-Score:5.41|P-value:1.87E-8 ID:SGTC_1356|Compound:1502-0781|FD-Score:-4.88|P-value:3.60E-7 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.07|P-value:8.99E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:-3.31|P-value:3.88E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.36|P-value:3.17E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:4.23|P-value:8.47E-6 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.79|P-value:5.89E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.59|P-value:1.31E-4 ID:SGTC_1646|Compound:st011709|FD-Score:-3.62|P-value:1.20E-4 ID:SGTC_1649|Compound:st011737|FD-Score:3.93|P-value:3.20E-5 ID:SGTC_1836|Compound:st055642|FD-Score:3.16|P-value:6.55E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-6.85|P-value:1.77E-12 ID:SGTC_1852|Compound:st056254|FD-Score:-3.55|P-value:1.58E-4 ID:SGTC_1867|Compound:st057372|FD-Score:-3.87|P-value:4.30E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:-6.45|P-value:2.86E-11 ID:SGTC_1873|Compound:rapamycin|FD-Score:-8.06|P-value:1.27E-16 ID:SGTC_1874|Compound:staurosporine|FD-Score:-5.00|P-value:1.91E-7 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-6.11|P-value:2.63E-10 ID:SGTC_1916|Compound:st067606|FD-Score:-5.67|P-value:4.26E-9 ID:SGTC_1925|Compound:st057770|FD-Score:-3.26|P-value:4.62E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-4.29|P-value:6.67E-6 ID:SGTC_1984|Compound:st072354|FD-Score:-4.32|P-value:5.69E-6 ID:SGTC_1986|Compound:st071812|FD-Score:-3.31|P-value:3.92E-4 ID:SGTC_1987|Compound:st072290|FD-Score:-3.27|P-value:4.45E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.39|P-value:2.92E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-3.11|P-value:7.87E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.29|P-value:4.07E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.57|P-value:1.39E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.71|P-value:8.16E-5 ID:SGTC_2790|Compound:5423970|FD-Score:-3.84|P-value:4.89E-5 ID:SGTC_2848|Compound:9016370|FD-Score:-4.25|P-value:8.07E-6 ID:SGTC_2857|Compound:9024691|FD-Score:3.13|P-value:7.35E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.42|P-value:2.57E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-5.25|P-value:4.83E-8 ID:SGTC_2902|Compound:5787006|FD-Score:-3.57|P-value:1.44E-4 ID:SGTC_2914|Compound:7968218|FD-Score:-3.55|P-value:1.54E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.75|P-value:6.85E-5 ID:SGTC_3028|Compound:9087778|FD-Score:3.22|P-value:5.36E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.74|P-value:7.19E-5 ID:SGTC_3296|Compound:9122258|FD-Score:3.46|P-value:2.17E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.65|P-value:1.01E-4

Top fitness defect scores for YDL010W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1132 3456-3614 5.81 2.5 µM 1.73E-9 tubulin folding & SWR complex 11 3.10E-9
2 SGTC_1351 1496-0003 5.41 46.5 µM 1.87E-8 5 3.12E-8
3 SGTC_52 0329-0193 4.68 875.0 nM 9.95E-7 TSC3-RPN4 18 1.46E-6
4 SGTC_287 k060-0039 4.44 29.6 µM 3.10E-6 4 4.41E-6
5 SGTC_897 1000-0139 4.27 31.4 µM 7.19E-6 24 9.95E-6
6 SGTC_1492 4158-0558 4.23 28.5 µM 8.47E-6 60S ribosome export 11 1.17E-5
7 SGTC_317 4495-0002 4.14 170.0 µM 1.29E-5 8 1.75E-5
8 SGTC_1649 st011737 3.93 51.3 µM 3.20E-5 28 4.22E-5
9 SGTC_344 k064-0035 3.80 6.4 µM 5.58E-5 60S ribosome export 22 7.24E-5
10 SGTC_1509 1326-1131 3.79 80.0 µM 5.89E-5 15 7.64E-5
11 SGTC_213 1246-0773 3.77 967.0 nM 6.20E-5 25 8.02E-5
12 SGTC_2931 9014674 3.75 55.7 µM 6.85E-5 26 8.84E-5
13 SGTC_2391 6285546 3.71 200.0 µM 8.16E-5 23 1.05E-4
14 SGTC_3329 9141233 3.65 27.6 µM 1.01E-4 21 1.29E-4
15 SGTC_1580 hydrocortisone 21-hemisuccinate 3.59 43.2 µM 1.31E-4 28 1.65E-4
16 SGTC_2371 9071574 3.57 200.0 µM 1.39E-4 16 1.75E-4
17 SGTC_3296 9122258 3.46 64.0 µM 2.17E-4 redox potentiating 30 2.70E-4
18 SGTC_39 0986-0283 3.45 58.4 µM 2.29E-4 calcium & mitochondrial duress 56 2.84E-4
19 SGTC_2858 9025781 3.42 9.0 µM 2.57E-4 sphingolipid biosynthesis & PDR1 132 3.18E-4
20 SGTC_807 1315-0151 3.41 48.0 µM 2.62E-4 49 3.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.288 1.39E-64 YDR291W HRQ1 hom 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
0.176 1.17E-24 YOR092W ECM3 hom Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication
0.156 1.08E-19 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.155 1.89E-19 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.154 4.31E-19 YCR007C_p YCR007C_p hom Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
0.149 6.70E-18 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.141 3.00E-16 YLR244C MAP1 hom Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p
0.140 4.07E-16 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.126 2.56E-13 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.121 2.04E-12 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.117 1.05E-11 YOL118C_d YOL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.116 1.81E-11 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.115 2.27E-11 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.115 2.63E-11 YKR061W KTR2 hom Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication
0.111 1.39E-10 YMR114C YMR114C hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene