YDL011C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL011C / YDL011C

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:-3.67|P-value:7.43E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.29|P-value:3.40E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.86|P-value:2.51E-7 ID:SGTC_155|Compound:k072-0202|FD-Score:3.17|P-value:4.73E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.04|P-value:8.49E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.39|P-value:2.36E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.63|P-value:7.63E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.54|P-value:1.28E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:4.14|P-value:8.03E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.11|P-value:5.83E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.76|P-value:5.21E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:3.49|P-value:1.33E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.75|P-value:5.29E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:3.51|P-value:1.24E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:4.04|P-value:1.26E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.02|P-value:9.11E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:5.29|P-value:1.82E-8 ID:SGTC_997|Compound:3996-0078|FD-Score:-3.22|P-value:4.49E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.20|P-value:4.80E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.20|P-value:4.13E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.91|P-value:2.24E-5 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.59|P-value:8.91E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.12|P-value:5.60E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.05|P-value:7.10E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.54|P-value:1.26E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.12|P-value:5.54E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.64|P-value:7.29E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-3.55|P-value:1.23E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.25|P-value:4.02E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-3.51|P-value:1.46E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.39|P-value:2.04E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.58|P-value:9.29E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.12|P-value:6.49E-4 ID:SGTC_2424|Compound:5537928|FD-Score:3.40|P-value:1.93E-4 ID:SGTC_2432|Compound:5630864|FD-Score:-3.00|P-value:9.69E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.73|P-value:5.70E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.76|P-value:4.21E-7 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.59|P-value:1.05E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.25|P-value:3.89E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.14|P-value:5.89E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.94|P-value:1.98E-5 ID:SGTC_2783|Compound:7738165|FD-Score:3.35|P-value:2.30E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.80|P-value:4.23E-5 ID:SGTC_2906|Compound:7926292|FD-Score:3.29|P-value:2.98E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.20|P-value:4.77E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.02|P-value:8.00E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-4.21|P-value:6.84E-6 ID:SGTC_3263|Compound:9137018|FD-Score:-3.34|P-value:2.85E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.21|P-value:3.96E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-3.17|P-value:5.43E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:-3.67|P-value:7.43E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.29|P-value:3.40E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.86|P-value:2.51E-7 ID:SGTC_155|Compound:k072-0202|FD-Score:3.17|P-value:4.73E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.04|P-value:8.49E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.39|P-value:2.36E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.63|P-value:7.63E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.54|P-value:1.28E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:4.14|P-value:8.03E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.11|P-value:5.83E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.76|P-value:5.21E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:3.49|P-value:1.33E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.75|P-value:5.29E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:3.51|P-value:1.24E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:4.04|P-value:1.26E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.02|P-value:9.11E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:5.29|P-value:1.82E-8 ID:SGTC_997|Compound:3996-0078|FD-Score:-3.22|P-value:4.49E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.20|P-value:4.80E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.20|P-value:4.13E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.91|P-value:2.24E-5 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.59|P-value:8.91E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.12|P-value:5.60E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.05|P-value:7.10E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.54|P-value:1.26E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.12|P-value:5.54E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.64|P-value:7.29E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-3.55|P-value:1.23E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.25|P-value:4.02E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-3.51|P-value:1.46E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.39|P-value:2.04E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.58|P-value:9.29E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.12|P-value:6.49E-4 ID:SGTC_2424|Compound:5537928|FD-Score:3.40|P-value:1.93E-4 ID:SGTC_2432|Compound:5630864|FD-Score:-3.00|P-value:9.69E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.73|P-value:5.70E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.76|P-value:4.21E-7 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.59|P-value:1.05E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.25|P-value:3.89E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.14|P-value:5.89E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.94|P-value:1.98E-5 ID:SGTC_2783|Compound:7738165|FD-Score:3.35|P-value:2.30E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.80|P-value:4.23E-5 ID:SGTC_2906|Compound:7926292|FD-Score:3.29|P-value:2.98E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.20|P-value:4.77E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.02|P-value:8.00E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-4.21|P-value:6.84E-6 ID:SGTC_3263|Compound:9137018|FD-Score:-3.34|P-value:2.85E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.21|P-value:3.96E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-3.17|P-value:5.43E-4

Top fitness defect scores for YDL011C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_994 3910-0338 5.29 138.0 µM 1.82E-8 calcium & mitochondrial duress 19 6.28E-8
2 SGTC_545 4218-0007 4.14 221.0 µM 8.03E-6 23 1.77E-5
3 SGTC_763 3453-1109 4.04 128.0 µM 1.26E-5 12 2.68E-5
4 SGTC_2780 5215298 3.94 71.4 µM 1.98E-5 37 4.07E-5
5 SGTC_1005 4092-0690 3.91 4.4 µM 2.24E-5 plasma membrane duress 32 4.57E-5
6 SGTC_1720 st037298 3.64 9.5 µM 7.29E-5 42 1.37E-4
7 SGTC_538 2922-0838 3.63 53.3 µM 7.63E-5 Golgi 43 1.43E-4
8 SGTC_1221 2958-7315 3.59 257.0 µM 8.91E-5 25 1.65E-4
9 SGTC_2415 st077333 3.58 57.7 µM 9.29E-5 68 1.71E-4
10 SGTC_761 k216-0224 3.51 480.0 µM 1.24E-4 35 2.24E-4
11 SGTC_722 3534-0461 3.49 190.0 µM 1.33E-4 PDR1 52 2.39E-4
12 SGTC_2424 5537928 3.40 59.2 µM 1.93E-4 57 3.37E-4
13 SGTC_2363 9053361 3.39 176.0 µM 2.04E-4 Golgi 53 3.56E-4
14 SGTC_2783 7738165 3.35 71.4 µM 2.30E-4 50 3.97E-4
15 SGTC_2906 7926292 3.29 26.4 µM 2.98E-4 49 5.04E-4
16 SGTC_3266 9136860 3.21 49.5 µM 3.96E-4 cell wall 74 6.56E-4
17 SGTC_1004 4084-0029 3.20 199.0 µM 4.13E-4 50 6.83E-4
18 SGTC_155 k072-0202 3.17 43.6 µM 4.73E-4 43 7.74E-4
19 SGTC_1635 st007035 3.12 42.4 µM 5.54E-4 284 8.97E-4
20 SGTC_1230 0170-0365 3.12 3.8 µM 5.60E-4 endomembrane recycling 125 9.06E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.184 9.00E-27 YER171W RAD3 het 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress
0.143 9.65E-17 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.139 7.05E-16 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.125 3.69E-13 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.120 3.51E-12 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.119 4.47E-12 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.115 2.66E-11 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.111 1.03E-10 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.110 1.77E-10 YOR020W-A_p YOR020W-A_p hom Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.110 1.84E-10 YER115C SPR6 hom Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation
0.108 3.54E-10 YGR207C CIR1 hom Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response
0.107 4.83E-10 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.107 5.54E-10 YPL165C SET6 hom SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability
0.106 7.61E-10 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.106 8.56E-10 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification