YDL022W / GPD1

NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL022W / GPD1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:5.13|P-value:2.21E-7 ID:SGTC_43|Compound:0570-0105|FD-Score:3.50|P-value:2.82E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-10.90|P-value:8.26E-27 ID:SGTC_115|Compound:0527-0192|FD-Score:-4.48|P-value:6.62E-6 ID:SGTC_121|Compound:0557-0495|FD-Score:3.18|P-value:8.44E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:4.61|P-value:2.78E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:3.37|P-value:4.46E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:4.39|P-value:7.57E-6 ID:SGTC_496|Compound:calpeptin|FD-Score:-4.06|P-value:3.98E-5 ID:SGTC_500|Compound:h-89|FD-Score:3.67|P-value:1.46E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.60|P-value:2.93E-6 ID:SGTC_601|Compound:0986-0029|FD-Score:4.50|P-value:4.75E-6 ID:SGTC_758|Compound:0868-0029|FD-Score:-10.60|P-value:1.70E-25 ID:SGTC_873|Compound:0591-4978|FD-Score:4.45|P-value:5.93E-6 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.08|P-value:2.91E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.89|P-value:6.35E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.84|P-value:7.63E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.64|P-value:2.04E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.83|P-value:8.05E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:-5.76|P-value:1.01E-8 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.79|P-value:9.34E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.67|P-value:1.46E-4 ID:SGTC_1558|Compound:st069300|FD-Score:-3.23|P-value:8.66E-4 ID:SGTC_1646|Compound:st011709|FD-Score:4.14|P-value:2.22E-5 ID:SGTC_1655|Compound:st012546|FD-Score:-3.25|P-value:8.11E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.99|P-value:4.12E-5 ID:SGTC_1738|Compound:st035555|FD-Score:3.14|P-value:9.64E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.70|P-value:1.34E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.63|P-value:1.69E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.01|P-value:3.81E-5 ID:SGTC_1937|Compound:st074714|FD-Score:4.25|P-value:1.41E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-3.41|P-value:4.69E-4 ID:SGTC_1981|Compound:st071826|FD-Score:-4.09|P-value:3.47E-5 ID:SGTC_2069|Compound:5228469|FD-Score:3.81|P-value:8.66E-5 ID:SGTC_2086|Compound:5274770|FD-Score:6.82|P-value:1.01E-11 ID:SGTC_2103|Compound:5378138|FD-Score:3.63|P-value:1.74E-4 ID:SGTC_2189|Compound:6047310|FD-Score:3.26|P-value:6.46E-4 ID:SGTC_2231|Compound:micatex|FD-Score:3.21|P-value:7.62E-4 ID:SGTC_2318|Compound:6029776|FD-Score:4.22|P-value:1.61E-5 ID:SGTC_2341|Compound:7987486|FD-Score:3.59|P-value:2.02E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.93|P-value:5.41E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.35|P-value:4.70E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.22|P-value:7.40E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.07|P-value:3.02E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.64|P-value:1.67E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.31|P-value:6.52E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.65|P-value:1.95E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.83|P-value:1.01E-6 ID:SGTC_2864|Compound:9034755|FD-Score:-4.16|P-value:2.56E-5 ID:SGTC_2867|Compound:9039098|FD-Score:4.99|P-value:4.52E-7 ID:SGTC_2871|Compound:9038510|FD-Score:5.35|P-value:6.88E-8 ID:SGTC_3008|Compound:9078912|FD-Score:3.27|P-value:6.31E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-4.49|P-value:6.32E-6 ID:SGTC_3266|Compound:9136860|FD-Score:3.18|P-value:8.36E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.43|P-value:3.57E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:5.13|P-value:2.21E-7 ID:SGTC_43|Compound:0570-0105|FD-Score:3.50|P-value:2.82E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-10.90|P-value:8.26E-27 ID:SGTC_115|Compound:0527-0192|FD-Score:-4.48|P-value:6.62E-6 ID:SGTC_121|Compound:0557-0495|FD-Score:3.18|P-value:8.44E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:4.61|P-value:2.78E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:3.37|P-value:4.46E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:4.39|P-value:7.57E-6 ID:SGTC_496|Compound:calpeptin|FD-Score:-4.06|P-value:3.98E-5 ID:SGTC_500|Compound:h-89|FD-Score:3.67|P-value:1.46E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.60|P-value:2.93E-6 ID:SGTC_601|Compound:0986-0029|FD-Score:4.50|P-value:4.75E-6 ID:SGTC_758|Compound:0868-0029|FD-Score:-10.60|P-value:1.70E-25 ID:SGTC_873|Compound:0591-4978|FD-Score:4.45|P-value:5.93E-6 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.08|P-value:2.91E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.89|P-value:6.35E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.84|P-value:7.63E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.64|P-value:2.04E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.83|P-value:8.05E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:-5.76|P-value:1.01E-8 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.79|P-value:9.34E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.67|P-value:1.46E-4 ID:SGTC_1558|Compound:st069300|FD-Score:-3.23|P-value:8.66E-4 ID:SGTC_1646|Compound:st011709|FD-Score:4.14|P-value:2.22E-5 ID:SGTC_1655|Compound:st012546|FD-Score:-3.25|P-value:8.11E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.99|P-value:4.12E-5 ID:SGTC_1738|Compound:st035555|FD-Score:3.14|P-value:9.64E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.70|P-value:1.34E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.63|P-value:1.69E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.01|P-value:3.81E-5 ID:SGTC_1937|Compound:st074714|FD-Score:4.25|P-value:1.41E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-3.41|P-value:4.69E-4 ID:SGTC_1981|Compound:st071826|FD-Score:-4.09|P-value:3.47E-5 ID:SGTC_2069|Compound:5228469|FD-Score:3.81|P-value:8.66E-5 ID:SGTC_2086|Compound:5274770|FD-Score:6.82|P-value:1.01E-11 ID:SGTC_2103|Compound:5378138|FD-Score:3.63|P-value:1.74E-4 ID:SGTC_2189|Compound:6047310|FD-Score:3.26|P-value:6.46E-4 ID:SGTC_2231|Compound:micatex|FD-Score:3.21|P-value:7.62E-4 ID:SGTC_2318|Compound:6029776|FD-Score:4.22|P-value:1.61E-5 ID:SGTC_2341|Compound:7987486|FD-Score:3.59|P-value:2.02E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.93|P-value:5.41E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.35|P-value:4.70E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.22|P-value:7.40E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.07|P-value:3.02E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.64|P-value:1.67E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.31|P-value:6.52E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.65|P-value:1.95E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.83|P-value:1.01E-6 ID:SGTC_2864|Compound:9034755|FD-Score:-4.16|P-value:2.56E-5 ID:SGTC_2867|Compound:9039098|FD-Score:4.99|P-value:4.52E-7 ID:SGTC_2871|Compound:9038510|FD-Score:5.35|P-value:6.88E-8 ID:SGTC_3008|Compound:9078912|FD-Score:3.27|P-value:6.31E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-4.49|P-value:6.32E-6 ID:SGTC_3266|Compound:9136860|FD-Score:3.18|P-value:8.36E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.43|P-value:3.57E-4

Top fitness defect scores for YDL022W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2086 5274770 6.82 176.6 µM 1.01E-11 4 4.52E-12
2 SGTC_2871 9038510 5.35 13.0 µM 6.88E-8 5 4.30E-8
3 SGTC_35 0133-0054 5.13 64.1 µM 2.21E-7 10 1.44E-7
4 SGTC_2867 9039098 4.99 71.4 µM 4.52E-7 iron homeostasis 12 3.03E-7
5 SGTC_2781 5567276 4.83 71.4 µM 1.01E-6 24 6.95E-7
6 SGTC_122 0236-0016 4.61 402.4 µM 2.78E-6 RNA processing & uracil transport 22 1.99E-6
7 SGTC_501 nsc-95397 4.60 161.0 µM 2.93E-6 5 2.10E-6
8 SGTC_601 0986-0029 4.50 62.9 µM 4.75E-6 calcium & mitochondrial duress 23 3.46E-6
9 SGTC_873 0591-4978 4.45 488.0 µM 5.93E-6 9 4.36E-6
10 SGTC_328 k915-0120 4.39 63.5 µM 7.57E-6 TSC3-RPN4 12 5.62E-6
11 SGTC_1937 st074714 4.25 47.2 µM 1.41E-5 35 1.07E-5
12 SGTC_2318 6029776 4.22 164.0 µM 1.61E-5 20 1.23E-5
13 SGTC_1646 st011709 4.14 75.6 µM 2.22E-5 5 1.71E-5
14 SGTC_1053 3366-3204 4.08 134.0 µM 2.91E-5 cell wall 33 2.27E-5
15 SGTC_2755 lomerizine 4.07 42.7 µM 3.02E-5 22 2.35E-5
16 SGTC_1934 st074720 4.01 32.6 µM 3.81E-5 52 2.99E-5
17 SGTC_1726 st035556 3.99 14.6 µM 4.12E-5 33 3.24E-5
18 SGTC_2405 ticlatone 3.93 3.5 µM 5.41E-5 68 4.30E-5
19 SGTC_1146 3579-1023 3.89 7.0 µM 6.35E-5 17 5.07E-5
20 SGTC_1244 0416-0015 3.84 52.5 µM 7.63E-5 ERG2 34 6.14E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.294 8.31E-68 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.272 8.10E-58 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.236 1.58E-43 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.234 4.39E-43 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.227 1.61E-40 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.227 1.99E-40 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.223 7.35E-39 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.206 1.73E-33 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.199 2.97E-31 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.196 3.26E-30 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.191 7.85E-29 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.186 1.91E-27 YLR034C SMF3 hom Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress
0.185 3.05E-27 YOR033C EXO1 hom 5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress
0.183 1.17E-26 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.169 6.26E-23 YGR018C_p YGR018C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W