YDL054C / MCH1

Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL054C / MCH1

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:-3.57|P-value:2.39E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:4.57|P-value:4.12E-6 ID:SGTC_213|Compound:1246-0773|FD-Score:3.37|P-value:5.04E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.64|P-value:1.89E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.43|P-value:3.97E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.25|P-value:7.65E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:-3.43|P-value:3.96E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:-4.30|P-value:1.33E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:5.44|P-value:5.33E-8 ID:SGTC_1629|Compound:st005085|FD-Score:4.08|P-value:3.37E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.65|P-value:1.85E-4 ID:SGTC_1709|Compound:st033179|FD-Score:3.56|P-value:2.57E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.72|P-value:1.42E-4 ID:SGTC_2015|Compound:5119600|FD-Score:-4.88|P-value:9.56E-7 ID:SGTC_2017|Compound:5132927|FD-Score:3.48|P-value:3.44E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.20|P-value:8.92E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.55|P-value:2.66E-4 ID:SGTC_2537|Compound:larixol|FD-Score:8.36|P-value:1.64E-16 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.19|P-value:9.04E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.37|P-value:4.95E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.20|P-value:8.81E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-4.98|P-value:5.70E-7 ID:SGTC_2843|Compound:9000894|FD-Score:-3.84|P-value:8.67E-5 ID:SGTC_3043|Compound:9092303|FD-Score:3.90|P-value:7.04E-5 ID:SGTC_3094|Compound:9117742|FD-Score:-4.10|P-value:3.14E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:-3.57|P-value:2.39E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:4.57|P-value:4.12E-6 ID:SGTC_213|Compound:1246-0773|FD-Score:3.37|P-value:5.04E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.64|P-value:1.89E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.43|P-value:3.97E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.25|P-value:7.65E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:-3.43|P-value:3.96E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:-4.30|P-value:1.33E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:5.44|P-value:5.33E-8 ID:SGTC_1629|Compound:st005085|FD-Score:4.08|P-value:3.37E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.65|P-value:1.85E-4 ID:SGTC_1709|Compound:st033179|FD-Score:3.56|P-value:2.57E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.72|P-value:1.42E-4 ID:SGTC_2015|Compound:5119600|FD-Score:-4.88|P-value:9.56E-7 ID:SGTC_2017|Compound:5132927|FD-Score:3.48|P-value:3.44E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.20|P-value:8.92E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.55|P-value:2.66E-4 ID:SGTC_2537|Compound:larixol|FD-Score:8.36|P-value:1.64E-16 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.19|P-value:9.04E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.37|P-value:4.95E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.20|P-value:8.81E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-4.98|P-value:5.70E-7 ID:SGTC_2843|Compound:9000894|FD-Score:-3.84|P-value:8.67E-5 ID:SGTC_3043|Compound:9092303|FD-Score:3.90|P-value:7.04E-5 ID:SGTC_3094|Compound:9117742|FD-Score:-4.10|P-value:3.14E-5

Top fitness defect scores for YDL054C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2537 larixol 8.36 68.9 µM 1.64E-16 1 3.12E-17
2 SGTC_1512 0259-0544 5.44 12.2 µM 5.33E-8 3 2.60E-8
3 SGTC_61 0978-8327 4.57 98.6 µM 4.12E-6 ergosterol biosynthesis 15 2.47E-6
4 SGTC_1629 st005085 4.08 44.9 µM 3.37E-5 RPP1 & pyrimidine depletion 31 2.22E-5
5 SGTC_3043 9092303 3.90 49.5 µM 7.04E-5 19 4.81E-5
6 SGTC_1635 st007035 3.65 42.4 µM 1.85E-4 232 1.32E-4
7 SGTC_664 1222-0054 3.64 14.9 µM 1.89E-4 sphingolipid biosynthesis & PDR1 43 1.35E-4
8 SGTC_1709 st033179 3.56 39.1 µM 2.57E-4 23 1.86E-4
9 SGTC_2535 4',4'-dimethoxydalbergione 3.55 51.2 µM 2.66E-4 DNA damage response 24 1.93E-4
10 SGTC_2017 5132927 3.48 60.6 µM 3.44E-4 45 2.53E-4
11 SGTC_213 1246-0773 3.37 967.0 nM 5.04E-4 44 3.77E-4
12 SGTC_742 0kpi-0133 3.25 140.0 µM 7.65E-4 ERG2 43 5.84E-4
13 SGTC_2266 7929956 3.20 200.0 µM 8.92E-4 69 6.85E-4
14 SGTC_3085 9117376 3.13 49.5 µM 0.00111 36 8.61E-4
15 SGTC_178 4092-0806 3.12 87.5 µM 0.00118 ergosterol depletion effects on membrane 148 9.17E-4
16 SGTC_721 1187-1332 3.08 279.0 µM 0.00133 cell wall signaling 36 0.00104
17 SGTC_1215 3852-0577 3.03 11.2 µM 0.00156 48 0.00123
18 SGTC_711 k292-0785 3.03 179.0 µM 0.00157 DNA intercalators 56 0.00124
19 SGTC_1297 1068-0111 2.98 14.1 µM 0.00181 40 0.00144
20 SGTC_1132 3456-3614 2.98 2.5 µM 0.00181 tubulin folding & SWR complex 117 0.00144

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.12E-15 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.137 1.39E-15 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.125 4.44E-13 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.121 1.75E-12 YMR106C YKU80 hom Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
0.114 3.72E-11 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.113 4.99E-11 YDL009C_p YDL009C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene
0.110 1.44E-10 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.108 3.28E-10 YDL023C_d YDL023C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
0.105 1.01E-9 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.105 1.27E-9 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.104 1.57E-9 YML113W DAT1 hom DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability
0.102 2.68E-9 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.102 3.53E-9 YLR285C-A_p YLR285C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.099 1.04E-8 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.097 1.71E-8 YGR039W_d YGR039W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722