HIPHOP chemogenomics database

YDL061C / RPS29B

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YDL061C / RPS29B

Click on Significant Values for Screen Details

Top fitness defect scores for YDL061C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_800	3448-7362	7.03	155.0 µM	2.25E-13	translation	25	1.04E-12
2	SGTC_118	0083-0097	5.81	135.3 µM	1.04E-9	translation	27	3.10E-9
3	SGTC_830	4076-0286	5.33	57.8 µM	1.94E-8	translation	25	4.95E-8
4	SGTC_1266	0828-0227	5.14	32.9 µM	5.71E-8		7	1.38E-7
5	SGTC_2596	sinensetin	4.99	100.0 µM	1.27E-7		12	2.94E-7
6	SGTC_2336	9001819	4.97	198.7 µM	1.42E-7	heme biosynthesis & mitochondrial translocase	19	3.26E-7
7	SGTC_2822	7994718	4.96	71.4 µM	1.54E-7		9	3.51E-7
8	SGTC_387	norethindrone acetate	4.94	66.7 µM	1.75E-7		3	3.98E-7
9	SGTC_2688	kanamycin b	4.56	96.7 µM	1.22E-6	calcium & mitochondrial duress	287	2.50E-6
10	SGTC_1150	3909-7983	4.40	10.9 µM	2.72E-6		15	5.34E-6
11	SGTC_1238	0333-0287	4.32	48.8 µM	3.99E-6	Golgi	16	7.68E-6
12	SGTC_2075	5212009	4.26	200.0 µM	5.28E-6		6	1.00E-5
13	SGTC_1567	st069303	4.15	68.4 µM	8.96E-6	mitochondrial processes	17	1.65E-5
14	SGTC_1228	0124-0032	4.08	52.5 µM	1.25E-5		12	2.25E-5
15	SGTC_1734	st037168	4.07	69.4 µM	1.33E-5		20	2.40E-5
16	SGTC_2907	7721985	4.04	69.9 µM	1.50E-5		18	2.68E-5
17	SGTC_1372	2752-0194	3.83	270.0 µM	3.81E-5		19	6.50E-5
18	SGTC_562	3772-2733	3.80	112.0 µM	4.30E-5	ERG2	86	7.28E-5
19	SGTC_1543	azetidyl-2-carboxylic acid	3.75	198.0 µM	5.22E-5		19	8.75E-5
20	SGTC_1792	st045773	3.67	43.6 µM	7.49E-5		37	1.23E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.165	7.32E-22	YJL188C_d	BUD19_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.163	1.77E-21	YLR048W	RPS0B	hom	Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.161	6.80E-21	YJL189W	RPL39	hom	Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.143	9.19E-17	YHR203C	RPS4B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication
0.138	1.22E-15	YEL054C	RPL12A	hom	Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.136	2.37E-15	YKL110C	KTI12	hom	Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.133	9.90E-15	YOR235W_d	IRC13_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
0.132	1.82E-14	YLR061W	RPL22A	hom	Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.131	2.60E-14	YPL249C-A	RPL36B	hom	Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication
0.129	5.78E-14	YLR062C_d	BUD28_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.128	1.01E-13	YLR068W	FYV7	hom	Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.125	3.29E-13	YML061C	PIF1	hom	DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.124	5.83E-13	YLR287C-A	RPS30A	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication
0.119	4.62E-12	YOR309C_d	YOR309C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.118	6.07E-12	YIL008W	URM1	hom	Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response