YDL069C / CBS1

Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL069C / CBS1

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:3.25|P-value:8.12E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.46|P-value:7.32E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:4.30|P-value:1.50E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:6.47|P-value:1.61E-10 ID:SGTC_149|Compound:3970-0822|FD-Score:3.51|P-value:3.27E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.63|P-value:2.09E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.27|P-value:1.59E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:6.66|P-value:4.97E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:15.50|P-value:1.47E-51 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.07|P-value:2.19E-15 ID:SGTC_310|Compound:1273-0058|FD-Score:6.98|P-value:5.80E-12 ID:SGTC_386|Compound:1509-0011|FD-Score:5.07|P-value:4.28E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.95|P-value:6.04E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:-4.28|P-value:1.52E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:6.02|P-value:2.51E-9 ID:SGTC_885|Compound:0865-0106|FD-Score:3.18|P-value:9.98E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.84|P-value:9.69E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.86|P-value:9.05E-5 ID:SGTC_1088|Compound:bifonazole|FD-Score:-3.89|P-value:7.53E-5 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.27|P-value:7.62E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:-3.77|P-value:1.22E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:-3.41|P-value:4.51E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.33|P-value:6.05E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.31|P-value:6.64E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.91|P-value:7.00E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.73|P-value:1.47E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.74|P-value:1.41E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.42|P-value:4.26E-4 ID:SGTC_1815|Compound:st051655|FD-Score:-3.24|P-value:8.00E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.82|P-value:9.73E-5 ID:SGTC_2087|Compound:5276107|FD-Score:3.25|P-value:8.02E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.55|P-value:2.85E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:14.60|P-value:7.61E-46 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.44|P-value:4.08E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.33|P-value:6.23E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.63|P-value:3.46E-6 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.27|P-value:7.43E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.27|P-value:7.57E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.72|P-value:1.43E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.27|P-value:7.61E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.29|P-value:6.75E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.28|P-value:7.29E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-5.07|P-value:3.92E-7 ID:SGTC_2975|Compound:9084847|FD-Score:4.99|P-value:6.20E-7 ID:SGTC_2977|Compound:9011197|FD-Score:3.66|P-value:1.91E-4 ID:SGTC_3192|Compound:9110362|FD-Score:3.25|P-value:8.09E-4 ID:SGTC_3250|Compound:9135583|FD-Score:3.83|P-value:9.95E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:3.25|P-value:8.12E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.46|P-value:7.32E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:4.30|P-value:1.50E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:6.47|P-value:1.61E-10 ID:SGTC_149|Compound:3970-0822|FD-Score:3.51|P-value:3.27E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.63|P-value:2.09E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.27|P-value:1.59E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:6.66|P-value:4.97E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:15.50|P-value:1.47E-51 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.07|P-value:2.19E-15 ID:SGTC_310|Compound:1273-0058|FD-Score:6.98|P-value:5.80E-12 ID:SGTC_386|Compound:1509-0011|FD-Score:5.07|P-value:4.28E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.95|P-value:6.04E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:-4.28|P-value:1.52E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:6.02|P-value:2.51E-9 ID:SGTC_885|Compound:0865-0106|FD-Score:3.18|P-value:9.98E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.84|P-value:9.69E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.86|P-value:9.05E-5 ID:SGTC_1088|Compound:bifonazole|FD-Score:-3.89|P-value:7.53E-5 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.27|P-value:7.62E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:-3.77|P-value:1.22E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:-3.41|P-value:4.51E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.33|P-value:6.05E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.31|P-value:6.64E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.91|P-value:7.00E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.73|P-value:1.47E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.74|P-value:1.41E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.42|P-value:4.26E-4 ID:SGTC_1815|Compound:st051655|FD-Score:-3.24|P-value:8.00E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.82|P-value:9.73E-5 ID:SGTC_2087|Compound:5276107|FD-Score:3.25|P-value:8.02E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.55|P-value:2.85E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:14.60|P-value:7.61E-46 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.44|P-value:4.08E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.33|P-value:6.23E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.63|P-value:3.46E-6 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.27|P-value:7.43E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.27|P-value:7.57E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.72|P-value:1.43E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.27|P-value:7.61E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.29|P-value:6.75E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.28|P-value:7.29E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-5.07|P-value:3.92E-7 ID:SGTC_2975|Compound:9084847|FD-Score:4.99|P-value:6.20E-7 ID:SGTC_2977|Compound:9011197|FD-Score:3.66|P-value:1.91E-4 ID:SGTC_3192|Compound:9110362|FD-Score:3.25|P-value:8.09E-4 ID:SGTC_3250|Compound:9135583|FD-Score:3.83|P-value:9.95E-5

Top fitness defect scores for YDL069C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 15.50 5.3 µM 1.47E-51 94 1.99E-54
2 SGTC_2408 sulbentine 14.60 18.4 µM 7.61E-46 1 2.19E-48
3 SGTC_275 trichlorophene 8.07 5.7 µM 2.19E-15 mitochondrial stress 75 3.49E-16
4 SGTC_310 1273-0058 6.98 1.1 µM 5.80E-12 mitochondrial stress 117 1.45E-12
5 SGTC_168 3970-0862 6.66 530.5 µM 4.97E-11 33 1.41E-11
6 SGTC_134 0269-0018 6.47 6.9 µM 1.61E-10 75 4.87E-11
7 SGTC_802 4112-3352 6.02 742.0 µM 2.51E-9 3 8.87E-10
8 SGTC_386 1509-0011 5.07 3.1 µM 4.28E-7 105 2.02E-7
9 SGTC_2975 9084847 4.99 53.7 µM 6.20E-7 6 2.99E-7
10 SGTC_2419 paclitaxel 4.63 166.5 µM 3.46E-6 22 1.84E-6
11 SGTC_118 0083-0097 4.46 135.3 µM 7.32E-6 translation 86 4.06E-6
12 SGTC_119 0121-0043 4.30 24.8 µM 1.50E-5 mitochondrial stress 86 8.65E-6
13 SGTC_1027 k015-0025 3.86 8.7 µM 9.05E-5 29 5.77E-5
14 SGTC_1022 4477-0945 3.84 21.3 µM 9.69E-5 26 6.20E-5
15 SGTC_3250 9135583 3.83 49.5 µM 9.95E-5 12 6.38E-5
16 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 3.74 61.9 µM 1.41E-4 23 9.21E-5
17 SGTC_1385 3091-4834 3.73 14.1 µM 1.47E-4 RPP1 & pyrimidine depletion 25 9.62E-5
18 SGTC_2977 9011197 3.66 71.4 µM 1.91E-4 25 1.27E-4
19 SGTC_150 3970-0969 3.63 77.2 µM 2.09E-4 78 1.40E-4
20 SGTC_2344 7990960 3.55 77.0 µM 2.85E-4 38 1.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.486 2.21E-198 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.472 3.70E-185 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.446 1.41E-163 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.445 1.95E-162 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.426 1.83E-147 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.424 2.52E-146 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.422 5.65E-145 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.419 7.84E-143 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.418 1.06E-141 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.413 6.40E-138 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.411 6.16E-137 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.406 4.73E-133 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.403 4.26E-131 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.395 1.10E-125 YDL068W_d YDL068W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.392 1.11E-123 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p