YDL086W_p

Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL086W / YDL086W

Click on Significant Values for Screen Details ID:SGTC_148|Compound:3253-0744|FD-Score:-3.33|P-value:3.15E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:2.71|P-value:5.50E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:2.98|P-value:1.66E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:-2.86|P-value:2.92E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:2.79|P-value:3.86E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:-2.95|P-value:1.96E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-2.71|P-value:5.62E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:2.70|P-value:5.62E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:5.03|P-value:6.96E-10 ID:SGTC_1010|Compound:4112-3296|FD-Score:-2.94|P-value:2.07E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.38|P-value:4.41E-11 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.46|P-value:1.52E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.11|P-value:9.46E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:2.93|P-value:2.04E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.23|P-value:5.14E-5 ID:SGTC_1563|Compound:conessine|FD-Score:2.78|P-value:3.95E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-2.58|P-value:9.62E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.28|P-value:1.24E-7 ID:SGTC_1743|Compound:st037606|FD-Score:2.98|P-value:1.64E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.73|P-value:3.65E-6 ID:SGTC_2008|Compound:4012253|FD-Score:-3.71|P-value:4.13E-6 ID:SGTC_2128|Compound:5255449|FD-Score:4.17|P-value:2.45E-7 ID:SGTC_2135|Compound:5326629|FD-Score:-2.78|P-value:4.21E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-4.15|P-value:3.07E-7 ID:SGTC_2241|Compound:6772625|FD-Score:-4.92|P-value:1.71E-9 ID:SGTC_2245|Compound:6637752|FD-Score:3.68|P-value:4.62E-6 ID:SGTC_2316|Compound:5844804|FD-Score:3.77|P-value:2.77E-6 ID:SGTC_2322|Compound:7413319|FD-Score:2.68|P-value:6.15E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-2.83|P-value:3.40E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:2.61|P-value:8.27E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:2.57|P-value:9.53E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:2.98|P-value:1.63E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.41|P-value:2.06E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.89|P-value:1.85E-9 ID:SGTC_2576|Compound:guaiol|FD-Score:3.22|P-value:5.20E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.11|P-value:9.11E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.29|P-value:3.83E-5 ID:SGTC_2663|Compound:amphotericin b|FD-Score:2.78|P-value:4.03E-4 ID:SGTC_2693|Compound:st077581|FD-Score:2.69|P-value:5.85E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-2.88|P-value:2.67E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.14|P-value:7.92E-5 ID:SGTC_2871|Compound:9038510|FD-Score:2.73|P-value:4.86E-4 ID:SGTC_2876|Compound:9059903|FD-Score:2.93|P-value:2.05E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.54|P-value:9.86E-6 ID:SGTC_3015|Compound:9080845|FD-Score:3.13|P-value:8.03E-5 ID:SGTC_3018|Compound:9082602|FD-Score:3.03|P-value:1.26E-4 ID:SGTC_3067|Compound:9117431|FD-Score:-2.61|P-value:8.65E-4 ID:SGTC_3209|Compound:9113616|FD-Score:2.73|P-value:4.99E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-2.78|P-value:4.28E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.33|P-value:3.15E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:2.71|P-value:5.50E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:2.98|P-value:1.66E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:-2.86|P-value:2.92E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:2.79|P-value:3.86E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:-2.95|P-value:1.96E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-2.71|P-value:5.62E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:2.70|P-value:5.62E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:5.03|P-value:6.96E-10 ID:SGTC_1010|Compound:4112-3296|FD-Score:-2.94|P-value:2.07E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.38|P-value:4.41E-11 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.46|P-value:1.52E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.11|P-value:9.46E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:2.93|P-value:2.04E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.23|P-value:5.14E-5 ID:SGTC_1563|Compound:conessine|FD-Score:2.78|P-value:3.95E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-2.58|P-value:9.62E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.28|P-value:1.24E-7 ID:SGTC_1743|Compound:st037606|FD-Score:2.98|P-value:1.64E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.73|P-value:3.65E-6 ID:SGTC_2008|Compound:4012253|FD-Score:-3.71|P-value:4.13E-6 ID:SGTC_2128|Compound:5255449|FD-Score:4.17|P-value:2.45E-7 ID:SGTC_2135|Compound:5326629|FD-Score:-2.78|P-value:4.21E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-4.15|P-value:3.07E-7 ID:SGTC_2241|Compound:6772625|FD-Score:-4.92|P-value:1.71E-9 ID:SGTC_2245|Compound:6637752|FD-Score:3.68|P-value:4.62E-6 ID:SGTC_2316|Compound:5844804|FD-Score:3.77|P-value:2.77E-6 ID:SGTC_2322|Compound:7413319|FD-Score:2.68|P-value:6.15E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-2.83|P-value:3.40E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:2.61|P-value:8.27E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:2.57|P-value:9.53E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:2.98|P-value:1.63E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.41|P-value:2.06E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.89|P-value:1.85E-9 ID:SGTC_2576|Compound:guaiol|FD-Score:3.22|P-value:5.20E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.11|P-value:9.11E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.29|P-value:3.83E-5 ID:SGTC_2663|Compound:amphotericin b|FD-Score:2.78|P-value:4.03E-4 ID:SGTC_2693|Compound:st077581|FD-Score:2.69|P-value:5.85E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-2.88|P-value:2.67E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.14|P-value:7.92E-5 ID:SGTC_2871|Compound:9038510|FD-Score:2.73|P-value:4.86E-4 ID:SGTC_2876|Compound:9059903|FD-Score:2.93|P-value:2.05E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.54|P-value:9.86E-6 ID:SGTC_3015|Compound:9080845|FD-Score:3.13|P-value:8.03E-5 ID:SGTC_3018|Compound:9082602|FD-Score:3.03|P-value:1.26E-4 ID:SGTC_3067|Compound:9117431|FD-Score:-2.61|P-value:8.65E-4 ID:SGTC_3209|Compound:9113616|FD-Score:2.73|P-value:4.99E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-2.78|P-value:4.28E-4

Top fitness defect scores for YDL086W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1083 didemethylchlorpromazine sulfoxide 5.38 707.4 nM 4.41E-11 redox potentiating 40 3.67E-8
2 SGTC_996 3970-0799 5.03 1.8 µM 6.96E-10 52 2.51E-7
3 SGTC_2568 diosmetin 4.89 100.0 µM 1.85E-9 11 4.96E-7
4 SGTC_1741 st038134 4.28 10.2 µM 1.24E-7 25 9.34E-6
5 SGTC_2128 5255449 4.17 168.5 µM 2.45E-7 30 1.50E-5
6 SGTC_2316 5844804 3.77 197.4 µM 2.77E-6 39 8.22E-5
7 SGTC_2245 6637752 3.68 200.0 µM 4.62E-6 22 1.17E-4
8 SGTC_3013 9080133 3.54 71.4 µM 9.86E-6 34 2.00E-4
9 SGTC_1125 tnp00248 3.46 1.3 µM 1.52E-5 56 2.72E-4
10 SGTC_2576 guaiol 3.22 23.1 µM 5.20E-5 62 6.44E-4
11 SGTC_3015 9080845 3.13 49.5 µM 8.03E-5 29 8.75E-4
12 SGTC_3018 9082602 3.03 49.5 µM 1.26E-4 73 0.00120
13 SGTC_2497 7-hydroxyflavone 2.98 100.0 µM 1.63E-4 54 0.00144
14 SGTC_1743 st037606 2.98 46.4 µM 1.64E-4 76 0.00145
15 SGTC_288 1315-0019 2.98 35.1 µM 1.66E-4 RSC & ERG11 72 0.00146
16 SGTC_1127 asiatic acid 2.93 681.4 nM 2.04E-4 83 0.00169
17 SGTC_2876 9059903 2.93 26.0 µM 2.05E-4 50 0.00169
18 SGTC_815 1582-0027 2.79 36.9 µM 3.86E-4 87 0.00265
19 SGTC_1563 conessine 2.78 56.1 µM 3.95E-4 80 0.00269
20 SGTC_2663 amphotericin b 2.78 100.0 µM 4.03E-4 53 0.00274

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.262 9.04E-54 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.257 1.28E-51 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.242 7.08E-46 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.234 4.08E-43 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.230 1.48E-41 YPR011C_p YPR011C_p hom Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.225 8.26E-40 YGL131C SNT2 hom DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.222 1.00E-38 YMR112C MED11 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
0.219 1.10E-37 YDR109C_p YDR109C_p hom Putative kinase
0.215 2.50E-36 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.215 2.41E-36 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.214 6.64E-36 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.206 2.43E-33 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.202 5.13E-32 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.199 3.38E-31 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.196 1.88E-30 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments