YDL091C / UBX3

Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL091C / UBX3

Click on Significant Values for Screen Details ID:SGTC_234|Compound:nsc-17383|FD-Score:-2.82|P-value:6.58E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:2.77|P-value:9.52E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:2.81|P-value:8.08E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.09|P-value:2.69E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:3.23|P-value:1.44E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:-3.31|P-value:8.15E-5 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-2.78|P-value:7.61E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-2.88|P-value:5.12E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.01|P-value:3.02E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:-3.25|P-value:1.07E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.72|P-value:9.69E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:-4.61|P-value:8.04E-8 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.11|P-value:2.49E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.07|P-value:2.34E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.24|P-value:1.37E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:4.99|P-value:1.01E-8 ID:SGTC_1333|Compound:1482-0047|FD-Score:2.91|P-value:5.47E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.83|P-value:6.56E-6 ID:SGTC_1743|Compound:st037606|FD-Score:3.37|P-value:7.68E-5 ID:SGTC_1960|Compound:st011366|FD-Score:-3.17|P-value:1.50E-4 ID:SGTC_1962|Compound:st076595|FD-Score:2.91|P-value:5.46E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.54|P-value:3.56E-5 ID:SGTC_2008|Compound:4012253|FD-Score:-4.40|P-value:2.87E-7 ID:SGTC_2241|Compound:6772625|FD-Score:-2.73|P-value:9.14E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.28|P-value:1.18E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.16|P-value:1.99E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-2.92|P-value:4.27E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.52|P-value:3.08E-5 ID:SGTC_2711|Compound:st079103|FD-Score:-2.73|P-value:9.34E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-3.54|P-value:2.83E-5 ID:SGTC_3108|Compound:9121785|FD-Score:4.06|P-value:2.61E-6 ID:SGTC_3148|Compound:9097893|FD-Score:2.84|P-value:7.39E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-2.79|P-value:7.39E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:-2.82|P-value:6.58E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:2.77|P-value:9.52E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:2.81|P-value:8.08E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.09|P-value:2.69E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:3.23|P-value:1.44E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:-3.31|P-value:8.15E-5 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-2.78|P-value:7.61E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-2.88|P-value:5.12E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.01|P-value:3.02E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:-3.25|P-value:1.07E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.72|P-value:9.69E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:-4.61|P-value:8.04E-8 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.11|P-value:2.49E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.07|P-value:2.34E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.24|P-value:1.37E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:4.99|P-value:1.01E-8 ID:SGTC_1333|Compound:1482-0047|FD-Score:2.91|P-value:5.47E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.83|P-value:6.56E-6 ID:SGTC_1743|Compound:st037606|FD-Score:3.37|P-value:7.68E-5 ID:SGTC_1960|Compound:st011366|FD-Score:-3.17|P-value:1.50E-4 ID:SGTC_1962|Compound:st076595|FD-Score:2.91|P-value:5.46E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.54|P-value:3.56E-5 ID:SGTC_2008|Compound:4012253|FD-Score:-4.40|P-value:2.87E-7 ID:SGTC_2241|Compound:6772625|FD-Score:-2.73|P-value:9.14E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.28|P-value:1.18E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.16|P-value:1.99E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-2.92|P-value:4.27E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.52|P-value:3.08E-5 ID:SGTC_2711|Compound:st079103|FD-Score:-2.73|P-value:9.34E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-3.54|P-value:2.83E-5 ID:SGTC_3108|Compound:9121785|FD-Score:4.06|P-value:2.61E-6 ID:SGTC_3148|Compound:9097893|FD-Score:2.84|P-value:7.39E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-2.79|P-value:7.39E-4

Top fitness defect scores for YDL091C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1262 0737-0114 4.99 49.6 µM 1.01E-8 7 3.05E-7
2 SGTC_3108 9121785 4.06 49.5 µM 2.61E-6 10 2.51E-5
3 SGTC_1976 st070609 3.54 63.5 µM 3.56E-5 19 2.01E-4
4 SGTC_1743 st037606 3.37 46.4 µM 7.68E-5 40 3.71E-4
5 SGTC_2372 9071633 3.28 200.0 µM 1.18E-4 29 5.23E-4
6 SGTC_1257 0669-0121 3.24 16.0 µM 1.37E-4 61 5.90E-4
7 SGTC_330 1488-0319 3.23 80.1 µM 1.44E-4 RPP1 & pyrimidine depletion 33 6.15E-4
8 SGTC_2442 5158906 3.16 48.5 µM 1.99E-4 43 7.95E-4
9 SGTC_1198 1612-1005 3.11 86.7 µM 2.49E-4 43 9.50E-4
10 SGTC_326 k292-0812 3.09 17.5 µM 2.69E-4 24 0.00101
11 SGTC_1962 st076595 2.91 64.5 µM 5.46E-4 redox potentiating 94 0.00178
12 SGTC_1333 1482-0047 2.91 286.0 µM 5.47E-4 69 0.00179
13 SGTC_3148 9097893 2.84 49.5 µM 7.39E-4 90 0.00227
14 SGTC_319 1348-1596 2.81 45.5 µM 8.08E-4 RSC & ERG11 72 0.00244
15 SGTC_284 0988-0104 2.77 32.6 µM 9.52E-4 heme requiring 57 0.00279
16 SGTC_2633 5,7-dihydroxyisoflavone 2.70 100.0 µM 0.00125 91 0.00347
17 SGTC_410 α-linolenic acid 2.63 100.0 µM 0.00161 excess fatty acid 96 0.00426
18 SGTC_1312 1218-2183 2.62 165.0 µM 0.00166 63 0.00436
19 SGTC_2537 larixol 2.61 68.9 µM 0.00172 116 0.00448
20 SGTC_1569 carminic acid 2.60 40.6 µM 0.00183 93 0.00472

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.167 2.48E-22 YBR199W KTR4 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
0.159 2.98E-20 YBL081W_p YBL081W_p hom Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport
0.152 9.20E-19 YLR189C ATG26 hom UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
0.147 9.84E-18 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.147 1.35E-17 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.146 2.16E-17 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.143 9.32E-17 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.134 9.15E-15 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.133 1.30E-14 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.132 1.98E-14 YBR211C AME1 het Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress
0.128 9.54E-14 YIL042C PKP1 hom Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
0.128 1.06E-13 YFR025C HIS2 hom Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
0.127 1.33E-13 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.122 1.22E-12 YDL037C BSC1 hom Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.122 1.49E-12 YGR045C_d YGR045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data