HIPHOP chemogenomics database
YDL110C / TMA17 
Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YDL110C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.312 | 1.50E-76 | YBL036C | YBL036C | hom | Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS |
| 0.285 | 1.13E-63 | YKL179C | COY1 | hom | Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function |
| 0.263 | 5.16E-54 | YLR016C | PML1 | hom | Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p |
| 0.243 | 4.61E-46 | YLR353W | BUD8 | hom | Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole |
| 0.240 | 5.03E-45 | YKL131W_d | YKL131W_d | hom | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.234 | 1.03E-42 | YJL119C_d | YJL119C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.230 | 1.91E-41 | YOR298C-A | MBF1 | hom | Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress |
| 0.229 | 3.03E-41 | YAL060W | BDH1 | hom | NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source |
| 0.224 | 3.44E-39 | YFL063W_d | YFL063W_d | hom | Dubious open reading frame, based on available experimental and comparative sequence data |
| 0.222 | 9.37E-39 | YPR010C | RPA135 | het | RNA polymerase I second largest subunit A135 |
| 0.218 | 1.82E-37 | YHR003C | YHR003C | hom | Protein of unknown function, localized to the mitochondrial outer membrane |
| 0.217 | 5.14E-37 | YKL220C | FRE2 | hom | Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels |
| 0.217 | 6.71E-37 | YMR139W | RIM11 | hom | Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress |
| 0.215 | 2.49E-36 | YBL015W | ACH1 | hom | Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth |
| 0.214 | 6.07E-36 | YDR110W | FOB1 | hom | Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases |