YDL116W / NUP84

Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP107

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL116W / NUP84

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:-3.22|P-value:5.79E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:3.77|P-value:7.35E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.10|P-value:9.07E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.42|P-value:2.93E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.38|P-value:3.36E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.07|P-value:9.93E-4 ID:SGTC_446|Compound:go6976|FD-Score:-4.37|P-value:5.26E-6 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.49|P-value:2.23E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.70|P-value:9.65E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:3.89|P-value:4.51E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:3.19|P-value:6.67E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:3.35|P-value:3.81E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.38|P-value:3.32E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:-3.66|P-value:1.13E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.79|P-value:6.84E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:3.31|P-value:4.35E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.54|P-value:1.87E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.63|P-value:1.31E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.95|P-value:3.16E-7 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.64|P-value:1.26E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.50|P-value:2.13E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:4.64|P-value:1.47E-6 ID:SGTC_1492|Compound:4158-0558|FD-Score:4.59|P-value:1.92E-6 ID:SGTC_1594|Compound:piperine|FD-Score:4.47|P-value:3.43E-6 ID:SGTC_1610|Compound:st001799|FD-Score:3.75|P-value:7.95E-5 ID:SGTC_1617|Compound:st002906|FD-Score:3.26|P-value:5.14E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.54|P-value:1.84E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.54|P-value:1.82E-4 ID:SGTC_1833|Compound:st055984|FD-Score:4.28|P-value:8.05E-6 ID:SGTC_1836|Compound:st055642|FD-Score:-4.40|P-value:4.52E-6 ID:SGTC_1841|Compound:st054148|FD-Score:3.16|P-value:7.31E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.19|P-value:6.57E-4 ID:SGTC_1853|Compound:st056710|FD-Score:4.78|P-value:7.34E-7 ID:SGTC_1921|Compound:5740136|FD-Score:-3.41|P-value:2.95E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.16|P-value:7.40E-4 ID:SGTC_2036|Compound:5160441|FD-Score:3.70|P-value:9.78E-5 ID:SGTC_2060|Compound:5238662|FD-Score:3.96|P-value:3.40E-5 ID:SGTC_2357|Compound:9067248|FD-Score:4.96|P-value:3.04E-7 ID:SGTC_2399|Compound:5884133|FD-Score:4.22|P-value:1.09E-5 ID:SGTC_2423|Compound:st077119|FD-Score:3.27|P-value:5.00E-4 ID:SGTC_2441|Compound:5730946|FD-Score:4.52|P-value:2.69E-6 ID:SGTC_2570|Compound:licareol|FD-Score:4.51|P-value:2.81E-6 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.15|P-value:7.54E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.53|P-value:1.88E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-3.95|P-value:3.36E-5 ID:SGTC_3085|Compound:9117376|FD-Score:3.40|P-value:3.10E-4 ID:SGTC_3093|Compound:9117344|FD-Score:-3.20|P-value:6.25E-4 ID:SGTC_3101|Compound:9120531|FD-Score:4.09|P-value:1.93E-5 ID:SGTC_3131|Compound:9127911|FD-Score:3.24|P-value:5.54E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-3.33|P-value:3.95E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.22|P-value:5.79E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:3.77|P-value:7.35E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.10|P-value:9.07E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.42|P-value:2.93E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.38|P-value:3.36E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.07|P-value:9.93E-4 ID:SGTC_446|Compound:go6976|FD-Score:-4.37|P-value:5.26E-6 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.49|P-value:2.23E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.70|P-value:9.65E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:3.89|P-value:4.51E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:3.19|P-value:6.67E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:3.35|P-value:3.81E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.38|P-value:3.32E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:-3.66|P-value:1.13E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.79|P-value:6.84E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:3.31|P-value:4.35E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.54|P-value:1.87E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.63|P-value:1.31E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.95|P-value:3.16E-7 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.64|P-value:1.26E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.50|P-value:2.13E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:4.64|P-value:1.47E-6 ID:SGTC_1492|Compound:4158-0558|FD-Score:4.59|P-value:1.92E-6 ID:SGTC_1594|Compound:piperine|FD-Score:4.47|P-value:3.43E-6 ID:SGTC_1610|Compound:st001799|FD-Score:3.75|P-value:7.95E-5 ID:SGTC_1617|Compound:st002906|FD-Score:3.26|P-value:5.14E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.54|P-value:1.84E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.54|P-value:1.82E-4 ID:SGTC_1833|Compound:st055984|FD-Score:4.28|P-value:8.05E-6 ID:SGTC_1836|Compound:st055642|FD-Score:-4.40|P-value:4.52E-6 ID:SGTC_1841|Compound:st054148|FD-Score:3.16|P-value:7.31E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.19|P-value:6.57E-4 ID:SGTC_1853|Compound:st056710|FD-Score:4.78|P-value:7.34E-7 ID:SGTC_1921|Compound:5740136|FD-Score:-3.41|P-value:2.95E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.16|P-value:7.40E-4 ID:SGTC_2036|Compound:5160441|FD-Score:3.70|P-value:9.78E-5 ID:SGTC_2060|Compound:5238662|FD-Score:3.96|P-value:3.40E-5 ID:SGTC_2357|Compound:9067248|FD-Score:4.96|P-value:3.04E-7 ID:SGTC_2399|Compound:5884133|FD-Score:4.22|P-value:1.09E-5 ID:SGTC_2423|Compound:st077119|FD-Score:3.27|P-value:5.00E-4 ID:SGTC_2441|Compound:5730946|FD-Score:4.52|P-value:2.69E-6 ID:SGTC_2570|Compound:licareol|FD-Score:4.51|P-value:2.81E-6 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.15|P-value:7.54E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.53|P-value:1.88E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-3.95|P-value:3.36E-5 ID:SGTC_3085|Compound:9117376|FD-Score:3.40|P-value:3.10E-4 ID:SGTC_3093|Compound:9117344|FD-Score:-3.20|P-value:6.25E-4 ID:SGTC_3101|Compound:9120531|FD-Score:4.09|P-value:1.93E-5 ID:SGTC_3131|Compound:9127911|FD-Score:3.24|P-value:5.54E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-3.33|P-value:3.95E-4

Top fitness defect scores for YDL116W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2357 9067248 4.96 200.0 µM 3.04E-7 7 3.61E-7
2 SGTC_1394 3474-0001 4.95 65.7 µM 3.16E-7 endomembrane recycling 22 3.75E-7
3 SGTC_1853 st056710 4.78 91.2 µM 7.34E-7 amide catabolism 11 8.61E-7
4 SGTC_1491 4138-0063 4.64 26.5 µM 1.47E-6 3 1.71E-6
5 SGTC_1492 4158-0558 4.59 28.5 µM 1.92E-6 60S ribosome export 7 2.23E-6
6 SGTC_2441 5730946 4.52 39.1 µM 2.69E-6 8 3.10E-6
7 SGTC_2570 licareol 4.51 100.0 µM 2.81E-6 16 3.23E-6
8 SGTC_1594 piperine 4.47 70.1 µM 3.43E-6 6 3.94E-6
9 SGTC_1833 st055984 4.28 71.0 µM 8.05E-6 14 9.15E-6
10 SGTC_2399 5884133 4.22 200.0 µM 1.09E-5 cell wall signaling 61 1.23E-5
11 SGTC_3101 9120531 4.09 49.5 µM 1.93E-5 27 2.16E-5
12 SGTC_2060 5238662 3.96 140.0 µM 3.40E-5 28 3.79E-5
13 SGTC_598 3937-0236 3.89 20.2 µM 4.51E-5 ERG2 25 5.01E-5
14 SGTC_1050 3232-1156 3.79 69.3 µM 6.84E-5 RSC complex & mRNA processing 21 7.56E-5
15 SGTC_92 0063-0024 3.77 660.9 µM 7.35E-5 15 8.10E-5
16 SGTC_1610 st001799 3.75 48.1 µM 7.95E-5 14 8.76E-5
17 SGTC_590 k048-0076 3.70 22.4 µM 9.65E-5 RSC & ERG11 16 1.06E-4
18 SGTC_2036 5160441 3.70 105.0 µM 9.78E-5 NEO1 89 1.07E-4
19 SGTC_1413 3910-0535 3.64 34.4 µM 1.26E-4 19 1.38E-4
20 SGTC_1375 2910-0797 3.63 186.0 µM 1.31E-4 37 1.44E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.099 9.30E-9 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.094 4.32E-8 YJL183W MNN11 hom Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p
0.072 2.82E-5 YMR222C FSH2 hom Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2
0.072 2.97E-5 YPR139C LOA1 hom Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA
0.071 3.76E-5 YKL182W FAS1 het Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
0.071 3.91E-5 YKR104W YKR104W hom Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds
0.069 6.32E-5 YDR129C SAC6 hom Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.069 6.73E-5 YCL051W LRE1 hom Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway;
LRE1 has a paralog, HLR1, that arose from the whole genome duplication
0.068 8.17E-5 YAL058W CNE1 hom Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.067 9.88E-5 YOR348C PUT4 hom Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
0.066 1.20E-4 YPL095C EEB1 hom Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication
0.066 1.28E-4 YHR101C BIG1 het Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan
0.066 1.35E-4 YOR368W RAD17 hom Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins
0.066 1.36E-4 YBL076C ILS1 het Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A
0.065 1.50E-4 YDL231C BRE4 hom Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport