YDL121C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL121C / YDL121C

Click on Significant Values for Screen Details ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:3.00|P-value:3.64E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.94|P-value:4.27E-6 ID:SGTC_264|Compound:promethazine|FD-Score:-5.02|P-value:4.90E-9 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.64|P-value:1.98E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.31|P-value:7.42E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:3.05|P-value:2.98E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:2.91|P-value:5.25E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:2.92|P-value:5.03E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.23|P-value:1.36E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.19|P-value:1.61E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-2.76|P-value:7.78E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.45|P-value:4.89E-5 ID:SGTC_1507|Compound:4075-3230|FD-Score:2.78|P-value:8.91E-4 ID:SGTC_1775|Compound:st081588|FD-Score:-2.74|P-value:8.31E-4 ID:SGTC_1833|Compound:st055984|FD-Score:-2.91|P-value:4.14E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.86|P-value:6.45E-6 ID:SGTC_1915|Compound:st067105|FD-Score:-4.23|P-value:6.51E-7 ID:SGTC_1927|Compound:st060202|FD-Score:3.82|P-value:8.27E-6 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.00|P-value:3.18E-6 ID:SGTC_2135|Compound:5326629|FD-Score:-3.28|P-value:8.55E-5 ID:SGTC_2240|Compound:6690706|FD-Score:-4.48|P-value:1.49E-7 ID:SGTC_2309|Compound:7664088|FD-Score:2.97|P-value:4.04E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-2.77|P-value:7.50E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-4.18|P-value:8.68E-7 ID:SGTC_2589|Compound:lobaric acid|FD-Score:4.42|P-value:3.00E-7 ID:SGTC_2625|Compound:euphol|FD-Score:5.30|P-value:9.93E-10 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:2.78|P-value:8.89E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:4.38|P-value:3.84E-7 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.63|P-value:2.10E-5 ID:SGTC_2848|Compound:9016370|FD-Score:3.49|P-value:4.16E-5 ID:SGTC_2849|Compound:9019321|FD-Score:2.99|P-value:3.79E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.81|P-value:8.47E-6 ID:SGTC_3042|Compound:9091578|FD-Score:3.13|P-value:2.08E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.15|P-value:1.41E-6 ID:SGTC_3203|Compound:9113543|FD-Score:3.23|P-value:1.33E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-4.58|P-value:8.11E-8 ID:SGTC_3207|Compound:9114163|FD-Score:4.50|P-value:1.87E-7 ID:SGTC_3306|Compound:9127676|FD-Score:3.14|P-value:2.02E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.44|P-value:5.34E-5 ID:SGTC_3349|Compound:9149703|FD-Score:-2.81|P-value:6.21E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-2.81|P-value:6.36E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:3.00|P-value:3.64E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.94|P-value:4.27E-6 ID:SGTC_264|Compound:promethazine|FD-Score:-5.02|P-value:4.90E-9 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.64|P-value:1.98E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.31|P-value:7.42E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:3.05|P-value:2.98E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:2.91|P-value:5.25E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:2.92|P-value:5.03E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.23|P-value:1.36E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.19|P-value:1.61E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-2.76|P-value:7.78E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.45|P-value:4.89E-5 ID:SGTC_1507|Compound:4075-3230|FD-Score:2.78|P-value:8.91E-4 ID:SGTC_1775|Compound:st081588|FD-Score:-2.74|P-value:8.31E-4 ID:SGTC_1833|Compound:st055984|FD-Score:-2.91|P-value:4.14E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.86|P-value:6.45E-6 ID:SGTC_1915|Compound:st067105|FD-Score:-4.23|P-value:6.51E-7 ID:SGTC_1927|Compound:st060202|FD-Score:3.82|P-value:8.27E-6 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.00|P-value:3.18E-6 ID:SGTC_2135|Compound:5326629|FD-Score:-3.28|P-value:8.55E-5 ID:SGTC_2240|Compound:6690706|FD-Score:-4.48|P-value:1.49E-7 ID:SGTC_2309|Compound:7664088|FD-Score:2.97|P-value:4.04E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-2.77|P-value:7.50E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-4.18|P-value:8.68E-7 ID:SGTC_2589|Compound:lobaric acid|FD-Score:4.42|P-value:3.00E-7 ID:SGTC_2625|Compound:euphol|FD-Score:5.30|P-value:9.93E-10 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:2.78|P-value:8.89E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:4.38|P-value:3.84E-7 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.63|P-value:2.10E-5 ID:SGTC_2848|Compound:9016370|FD-Score:3.49|P-value:4.16E-5 ID:SGTC_2849|Compound:9019321|FD-Score:2.99|P-value:3.79E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.81|P-value:8.47E-6 ID:SGTC_3042|Compound:9091578|FD-Score:3.13|P-value:2.08E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.15|P-value:1.41E-6 ID:SGTC_3203|Compound:9113543|FD-Score:3.23|P-value:1.33E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-4.58|P-value:8.11E-8 ID:SGTC_3207|Compound:9114163|FD-Score:4.50|P-value:1.87E-7 ID:SGTC_3306|Compound:9127676|FD-Score:3.14|P-value:2.02E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.44|P-value:5.34E-5 ID:SGTC_3349|Compound:9149703|FD-Score:-2.81|P-value:6.21E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-2.81|P-value:6.36E-4

Top fitness defect scores for YDL121C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2625 euphol 5.30 100.0 µM 9.93E-10 9 5.66E-8
2 SGTC_3207 9114163 4.50 49.5 µM 1.87E-7 21 3.45E-6
3 SGTC_2589 lobaric acid 4.42 100.0 µM 3.00E-7 18 4.99E-6
4 SGTC_2639 lactacystin 4.38 53.0 µM 3.84E-7 16 6.05E-6
5 SGTC_3202 9113761 4.15 49.5 µM 1.41E-6 42 1.69E-5
6 SGTC_2130 NSC 7 4.00 2.5 µM 3.18E-6 copper-dependent oxidative stress 23 3.19E-5
7 SGTC_255 tunicamycin 3.94 200.5 nM 4.27E-6 unfolded protein response 74 4.03E-5
8 SGTC_1883 5-benzylidenerhodanine 3.86 20.0 µM 6.45E-6 TRP & mitochondrial translation 74 5.58E-5
9 SGTC_1927 st060202 3.82 13.8 µM 8.27E-6 21 6.78E-5
10 SGTC_2955 9076254 3.81 12.2 µM 8.47E-6 19 6.91E-5
11 SGTC_270 tamoxifen 3.64 5.5 µM 1.98E-5 NEO1 46 1.35E-4
12 SGTC_2690 usnic acid 3.63 100.0 µM 2.10E-5 36 1.42E-4
13 SGTC_2848 9016370 3.49 26.0 µM 4.16E-5 44 2.43E-4
14 SGTC_1254 0550-0035 3.45 264.0 µM 4.89E-5 36 2.76E-4
15 SGTC_3310 9130229 3.44 44.1 µM 5.34E-5 Golgi 44 2.96E-4
16 SGTC_3203 9113543 3.23 49.5 µM 1.33E-4 60 6.09E-4
17 SGTC_933 2914-0560 3.23 114.0 µM 1.36E-4 54 6.20E-4
18 SGTC_934 2950-0684 3.19 338.0 µM 1.61E-4 44 7.08E-4
19 SGTC_3306 9127676 3.14 59.8 µM 2.02E-4 54 8.49E-4
20 SGTC_3042 9091578 3.13 49.5 µM 2.08E-4 ERG2 21 8.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.158 3.36E-20 YBL043W ECM13 hom Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.151 1.39E-18 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.142 1.46E-16 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.137 1.93E-15 YGR122C-A_d YGR122C-A_d hom Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
0.135 5.85E-15 YLR343W GAS2 hom 1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p
0.123 1.08E-12 YLR112W_d YLR112W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.121 2.36E-12 YDR124W_p YDR124W_p hom Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
0.120 3.06E-12 YNR039C ZRG17 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency
0.119 4.15E-12 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.116 1.63E-11 YPL155C KIP2 hom Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle
0.114 4.13E-11 YDR208W MSS4 het Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
0.114 4.51E-11 YLR189C ATG26 hom UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
0.113 5.12E-11 YBR204C LDH1 hom Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)
0.113 5.63E-11 YBL040C ERD2 het HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins
0.110 1.71E-10 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress