YDL123W / SNA4

Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL123W / SNA4

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.97|P-value:6.52E-5 ID:SGTC_512|Compound:prima-1|FD-Score:-3.30|P-value:6.04E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.40|P-value:5.42E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.31|P-value:7.26E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.66|P-value:1.67E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.96|P-value:6.88E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:-3.22|P-value:7.79E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:-3.20|P-value:8.36E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:-3.28|P-value:6.47E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.90|P-value:6.47E-5 ID:SGTC_1997|Compound:st073024|FD-Score:-3.93|P-value:5.94E-5 ID:SGTC_2015|Compound:5119600|FD-Score:-3.76|P-value:1.13E-4 ID:SGTC_2018|Compound:5133068|FD-Score:5.33|P-value:1.34E-7 ID:SGTC_2023|Compound:5144124|FD-Score:3.36|P-value:6.28E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.62|P-value:2.48E-4 ID:SGTC_2694|Compound:st077685|FD-Score:3.57|P-value:3.01E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.36|P-value:6.12E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.42|P-value:5.02E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:3.97|P-value:6.52E-5 ID:SGTC_512|Compound:prima-1|FD-Score:-3.30|P-value:6.04E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.40|P-value:5.42E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.31|P-value:7.26E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.66|P-value:1.67E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.96|P-value:6.88E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:-3.22|P-value:7.79E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:-3.20|P-value:8.36E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:-3.28|P-value:6.47E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.90|P-value:6.47E-5 ID:SGTC_1997|Compound:st073024|FD-Score:-3.93|P-value:5.94E-5 ID:SGTC_2015|Compound:5119600|FD-Score:-3.76|P-value:1.13E-4 ID:SGTC_2018|Compound:5133068|FD-Score:5.33|P-value:1.34E-7 ID:SGTC_2023|Compound:5144124|FD-Score:3.36|P-value:6.28E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.62|P-value:2.48E-4 ID:SGTC_2694|Compound:st077685|FD-Score:3.57|P-value:3.01E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.36|P-value:6.12E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.42|P-value:5.02E-4

Top fitness defect scores for YDL123W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2018 5133068 5.33 143.0 µM 1.34E-7 5 4.86E-8
2 SGTC_17 0960-0276 3.97 49.8 µM 6.52E-5 29 3.53E-5
3 SGTC_1046 2001-0062 3.96 216.0 µM 6.88E-5 18 3.73E-5
4 SGTC_2501 sodium tetradecyl sulfate 3.62 13.4 µM 2.48E-4 42 1.47E-4
5 SGTC_2694 st077685 3.57 81.9 µM 3.01E-4 endomembrane recycling 43 1.80E-4
6 SGTC_3008 9078912 3.42 71.4 µM 5.02E-4 33 3.10E-4
7 SGTC_531 3788-1495 3.40 174.0 µM 5.42E-4 unfolded protein response 35 3.37E-4
8 SGTC_2762 leflunomide 3.36 42.1 µM 6.12E-4 55 3.84E-4
9 SGTC_2023 5144124 3.36 124.0 µM 6.28E-4 37 3.94E-4
10 SGTC_560 2332-1943 3.31 155.0 µM 7.26E-4 27 4.60E-4
11 SGTC_399 oxolinic acid 3.13 75.0 µM 0.00131 26 8.66E-4
12 SGTC_1330 1469-0054 3.04 61.8 µM 0.00177 iron homeostasis 50 0.00119
13 SGTC_3000 9075062 3.01 71.4 µM 0.00195 62 0.00132
14 SGTC_2383 9036125 2.99 200.0 µM 0.00204 27 0.00138
15 SGTC_170 4197-0004 2.99 226.0 µM 0.00206 51 0.00140
16 SGTC_94 0334-0113 2.97 514.8 µM 0.00216 68 0.00147
17 SGTC_1782 st039423 2.86 80.6 µM 0.00301 86 0.00209
18 SGTC_1323 1348-1351 2.82 11.2 µM 0.00344 51 0.00241
19 SGTC_2404 5161160 2.82 200.0 µM 0.00346 83 0.00243
20 SGTC_1564 D-Arginine 2.80 115.0 µM 0.00363 98 0.00256

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 3.57E-22 YOR176W HEM15 het Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
0.145 2.73E-17 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.138 9.33E-16 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.132 1.46E-14 YNR020C ATP23 hom Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p
0.119 4.94E-12 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.118 6.39E-12 YPR082C DIB1 het 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein
0.117 8.56E-12 YDR266C HEL2 hom RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor
0.112 7.43E-11 YPR073C LTP1 hom Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine
0.111 1.28E-10 YPL260W YPL260W hom Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress
0.097 1.54E-8 YDL045C FAD1 het Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
0.096 2.88E-8 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095 3.55E-8 YPR088C SRP54 het Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
0.092 9.26E-8 YDR302W GPI11 het ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
0.092 9.45E-8 YFR005C SAD1 het Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle
0.091 1.28E-7 YAR007C RFA1 het Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination