YDL127W / PCL2

Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL127W / PCL2

Click on Significant Values for Screen Details ID:SGTC_159|Compound:3970-0959|FD-Score:3.00|P-value:3.45E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.19|P-value:1.55E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-4.47|P-value:7.30E-7 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.14|P-value:3.92E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:2.90|P-value:5.13E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.12|P-value:2.12E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:2.76|P-value:8.87E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.27|P-value:1.12E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:3.23|P-value:1.31E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.51|P-value:8.60E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:2.76|P-value:8.81E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.48|P-value:4.50E-5 ID:SGTC_1407|Compound:3909-7909|FD-Score:-3.17|P-value:3.53E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.23|P-value:1.32E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.62|P-value:2.32E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:4.24|P-value:9.64E-7 ID:SGTC_1728|Compound:st035614|FD-Score:3.16|P-value:1.83E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.45|P-value:5.03E-5 ID:SGTC_2011|Compound:4012611|FD-Score:3.20|P-value:1.54E-4 ID:SGTC_2313|Compound:7726885|FD-Score:2.88|P-value:5.48E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-2.94|P-value:8.69E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.78|P-value:1.06E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.29|P-value:1.01E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.88|P-value:6.49E-6 ID:SGTC_2829|Compound:7992743|FD-Score:-5.02|P-value:2.93E-8 ID:SGTC_2835|Compound:9006588|FD-Score:3.34|P-value:8.45E-5 ID:SGTC_2853|Compound:9015042|FD-Score:3.39|P-value:6.60E-5 ID:SGTC_2857|Compound:9024691|FD-Score:5.11|P-value:5.75E-9 ID:SGTC_2900|Compound:5328528|FD-Score:-3.42|P-value:1.22E-4 ID:SGTC_3204|Compound:9114183|FD-Score:4.59|P-value:1.40E-7 ID:SGTC_3206|Compound:9114350|FD-Score:3.33|P-value:8.60E-5 ID:SGTC_3298|Compound:9116858|FD-Score:4.03|P-value:2.96E-6 ID:SGTC_3321|Compound:9137793|FD-Score:-5.33|P-value:4.04E-9 ID:SGTC_3327|Compound:9140648|FD-Score:3.90|P-value:5.88E-6 ID:SGTC_159|Compound:3970-0959|FD-Score:3.00|P-value:3.45E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.19|P-value:1.55E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-4.47|P-value:7.30E-7 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.14|P-value:3.92E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:2.90|P-value:5.13E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.12|P-value:2.12E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:2.76|P-value:8.87E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.27|P-value:1.12E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:3.23|P-value:1.31E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.51|P-value:8.60E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:2.76|P-value:8.81E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.48|P-value:4.50E-5 ID:SGTC_1407|Compound:3909-7909|FD-Score:-3.17|P-value:3.53E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.23|P-value:1.32E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.62|P-value:2.32E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:4.24|P-value:9.64E-7 ID:SGTC_1728|Compound:st035614|FD-Score:3.16|P-value:1.83E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.45|P-value:5.03E-5 ID:SGTC_2011|Compound:4012611|FD-Score:3.20|P-value:1.54E-4 ID:SGTC_2313|Compound:7726885|FD-Score:2.88|P-value:5.48E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-2.94|P-value:8.69E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.78|P-value:1.06E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.29|P-value:1.01E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.88|P-value:6.49E-6 ID:SGTC_2829|Compound:7992743|FD-Score:-5.02|P-value:2.93E-8 ID:SGTC_2835|Compound:9006588|FD-Score:3.34|P-value:8.45E-5 ID:SGTC_2853|Compound:9015042|FD-Score:3.39|P-value:6.60E-5 ID:SGTC_2857|Compound:9024691|FD-Score:5.11|P-value:5.75E-9 ID:SGTC_2900|Compound:5328528|FD-Score:-3.42|P-value:1.22E-4 ID:SGTC_3204|Compound:9114183|FD-Score:4.59|P-value:1.40E-7 ID:SGTC_3206|Compound:9114350|FD-Score:3.33|P-value:8.60E-5 ID:SGTC_3298|Compound:9116858|FD-Score:4.03|P-value:2.96E-6 ID:SGTC_3321|Compound:9137793|FD-Score:-5.33|P-value:4.04E-9 ID:SGTC_3327|Compound:9140648|FD-Score:3.90|P-value:5.88E-6

Top fitness defect scores for YDL127W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2857 9024691 5.11 58.4 µM 5.75E-9 9 1.65E-7
2 SGTC_3204 9114183 4.59 49.5 µM 1.40E-7 18 2.25E-6
3 SGTC_1718 roemerine 4.24 11.9 µM 9.64E-7 redox potentiating 46 1.10E-5
4 SGTC_3298 9116858 4.03 71.4 µM 2.96E-6 9 2.74E-5
5 SGTC_3327 9140648 3.90 26.9 µM 5.88E-6 13 4.81E-5
6 SGTC_2759 disulfiram 3.88 3.4 µM 6.49E-6 36 5.22E-5
7 SGTC_2432 5630864 3.78 12.2 µM 1.06E-5 24 7.80E-5
8 SGTC_1699 st031318 3.62 29.1 µM 2.32E-5 27 1.48E-4
9 SGTC_1319 1306-0155 3.48 43.7 µM 4.50E-5 41 2.54E-4
10 SGTC_2008 4012253 3.45 172.0 µM 5.03E-5 40 2.79E-4
11 SGTC_2853 9015042 3.39 58.4 µM 6.60E-5 42 3.48E-4
12 SGTC_2835 9006588 3.34 71.4 µM 8.45E-5 75 4.26E-4
13 SGTC_3206 9114350 3.33 49.5 µM 8.60E-5 41 4.32E-4
14 SGTC_2721 ifenprodil 3.29 61.4 µM 1.01E-4 plasma membrane duress 45 4.94E-4
15 SGTC_923 1900-2434 3.27 73.3 µM 1.12E-4 RNA processing & uracil transport 51 5.39E-4
16 SGTC_984 1492-0255 3.23 2.9 µM 1.31E-4 SWF1 & branched chain AA biosynthesis 53 6.09E-4
17 SGTC_1410 3909-8106 3.23 77.9 µM 1.32E-4 27 6.14E-4
18 SGTC_2011 4012611 3.20 177.0 µM 1.54E-4 mitochondrial processes 57 6.97E-4
19 SGTC_251 melphalan 3.19 456.5 µM 1.55E-4 DNA damage response 61 7.01E-4
20 SGTC_1728 st035614 3.16 33.8 µM 1.83E-4 97 8.02E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 5.79E-18 YPR013C_p CMR3_p hom Putative zinc finger protein; YPR013C is not an essential gene
0.118 5.68E-12 YML064C TEM1 het GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
0.117 8.55E-12 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.113 5.69E-11 YHR028C DAP2 hom Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p
0.112 7.28E-11 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.103 2.25E-9 YML111W BUL2 hom Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication
0.097 1.59E-8 YGR142W BTN2 hom v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication
0.094 5.16E-8 YMR175W SIP18 hom Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress
0.091 1.39E-7 YER073W ALD5 hom Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
0.087 4.09E-7 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.086 5.56E-7 YDR302W GPI11 het ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
0.082 1.86E-6 YMR179W SPT21 hom Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress
0.081 2.39E-6 YOR090C PTC5 hom Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p
0.076 1.01E-5 YKL168C KKQ8 hom Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication
0.076 1.19E-5 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids