YDL133C-A / RPL41B

Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL133C-A / RPL41B

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:-2.96|P-value:7.46E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:3.13|P-value:3.99E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:-3.02|P-value:5.83E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.07|P-value:4.81E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:7.53|P-value:3.17E-16 ID:SGTC_753|Compound:1322-0200|FD-Score:3.15|P-value:3.62E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.05|P-value:5.36E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.66|P-value:4.36E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:3.00|P-value:6.33E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.05|P-value:5.25E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:-3.13|P-value:3.90E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.48|P-value:9.30E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.16|P-value:3.45E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.04|P-value:7.19E-6 ID:SGTC_1943|Compound:st076331|FD-Score:-3.81|P-value:2.11E-5 ID:SGTC_2301|Compound:7769476|FD-Score:3.16|P-value:3.48E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-2.99|P-value:6.61E-4 ID:SGTC_2391|Compound:6285546|FD-Score:-2.89|P-value:9.45E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.90|P-value:1.40E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.28|P-value:2.11E-4 ID:SGTC_2601|Compound:securinine|FD-Score:-3.84|P-value:1.87E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.75|P-value:2.81E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.00|P-value:6.29E-4 ID:SGTC_2972|Compound:9093619|FD-Score:2.92|P-value:8.59E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.80|P-value:2.32E-5 ID:SGTC_3309|Compound:9129340|FD-Score:3.04|P-value:5.52E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-2.96|P-value:7.46E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:3.13|P-value:3.99E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:-3.02|P-value:5.83E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.07|P-value:4.81E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:7.53|P-value:3.17E-16 ID:SGTC_753|Compound:1322-0200|FD-Score:3.15|P-value:3.62E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.05|P-value:5.36E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.66|P-value:4.36E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:3.00|P-value:6.33E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.05|P-value:5.25E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:-3.13|P-value:3.90E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.48|P-value:9.30E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.16|P-value:3.45E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.04|P-value:7.19E-6 ID:SGTC_1943|Compound:st076331|FD-Score:-3.81|P-value:2.11E-5 ID:SGTC_2301|Compound:7769476|FD-Score:3.16|P-value:3.48E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-2.99|P-value:6.61E-4 ID:SGTC_2391|Compound:6285546|FD-Score:-2.89|P-value:9.45E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.90|P-value:1.40E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.28|P-value:2.11E-4 ID:SGTC_2601|Compound:securinine|FD-Score:-3.84|P-value:1.87E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.75|P-value:2.81E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.00|P-value:6.29E-4 ID:SGTC_2972|Compound:9093619|FD-Score:2.92|P-value:8.59E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.80|P-value:2.32E-5 ID:SGTC_3309|Compound:9129340|FD-Score:3.04|P-value:5.52E-4

Top fitness defect scores for YDL133C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_669 0108-0021 7.53 26.2 µM 3.17E-16 fatty acid desaturase (OLE1) 17 2.53E-14
2 SGTC_1673 st016611 4.04 27.3 µM 7.19E-6 42 2.64E-5
3 SGTC_2462 5162487 3.90 171.8 µM 1.40E-5 21 4.74E-5
4 SGTC_2987 9018338 3.80 71.4 µM 2.32E-5 RPP1 & pyrimidine depletion 21 7.35E-5
5 SGTC_882 0843-0131 3.66 351.0 µM 4.36E-5 21 1.28E-4
6 SGTC_1630 st005209 3.16 31.3 µM 3.45E-4 63 7.81E-4
7 SGTC_2301 7769476 3.16 200.0 µM 3.48E-4 46 7.86E-4
8 SGTC_753 1322-0200 3.15 289.0 µM 3.62E-4 56 8.14E-4
9 SGTC_303 1348-1668 3.13 34.2 µM 3.99E-4 16 8.86E-4
10 SGTC_823 0417-1665 3.05 178.0 µM 5.36E-4 70 0.00115
11 SGTC_3309 9129340 3.04 25.8 µM 5.52E-4 51 0.00118
12 SGTC_916 4466-0038 3.00 42.0 nM 6.33E-4 cell wall 147 0.00133
13 SGTC_2972 9093619 2.92 59.9 µM 8.59E-4 58 0.00174
14 SGTC_2563 tomatine 2.87 8.5 µM 0.00102 128 0.00202
15 SGTC_2458 5808907 2.83 16.4 µM 0.00119 33 0.00232
16 SGTC_2909 7941780 2.80 10.5 µM 0.00132 73 0.00254
17 SGTC_3048 9093155 2.80 49.5 µM 0.00133 30 0.00256
18 SGTC_3178 9107506 2.77 49.5 µM 0.00146 68 0.00277
19 SGTC_1500 4488-1866 2.77 171.0 µM 0.00149 RPP1 & pyrimidine depletion 79 0.00282
20 SGTC_1951 sophoraflavanone G 2.75 9.2 µM 0.00161 RNA processing & uracil transport 103 0.00302

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.236 8.57E-44 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.221 1.53E-38 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.214 5.51E-36 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.207 6.34E-34 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.207 9.74E-34 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.195 5.38E-30 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.189 1.78E-28 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.185 2.51E-27 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.183 1.34E-26 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.180 6.48E-26 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.172 8.24E-24 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.164 1.49E-21 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.163 2.00E-21 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.163 2.03E-21 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.161 5.47E-21 YLR137W RKM5 hom Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species