Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YDL133C-A deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.236 | 8.57E-44 | YOR037W | CYC2 | hom | Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p) |
0.221 | 1.53E-38 | YFL056C | AAD6 | hom | Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin |
0.214 | 5.51E-36 | YGL146C_p | RRT6_p | hom | Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins |
0.207 | 6.34E-34 | YBR083W | TEC1 | hom | Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member |
0.207 | 9.74E-34 | YBR207W | FTH1 | hom | Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress |
0.195 | 5.38E-30 | YCL076W_d | YCL076W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
0.189 | 1.78E-28 | YDR122W | KIN1 | hom | Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p |
0.185 | 2.51E-27 | YNL011C_p | YNL011C_p | hom | Putative protein of unknown function; YNL011C is not an essential gene |
0.183 | 1.34E-26 | YEL049W | PAU2 | hom | Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme |
0.180 | 6.48E-26 | YER066W_p | RRT13_p | hom | Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription |
0.172 | 8.24E-24 | YCR102W-A_d | YCR102W-A_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
0.164 | 1.49E-21 | YBL015W | ACH1 | hom | Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth |
0.163 | 2.00E-21 | YNR044W | AGA1 | hom | Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds |
0.163 | 2.03E-21 | YBL066C | SEF1 | hom | Putative transcription factor, has homolog in Kluyveromyces lactis |
0.161 | 5.47E-21 | YLR137W | RKM5 | hom | Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species |