YDL157C_p

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL157C / YDL157C

Click on Significant Values for Screen Details ID:SGTC_221|Compound:trifluoperazine|FD-Score:-2.73|P-value:9.42E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.25|P-value:5.37E-10 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:-3.06|P-value:2.41E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.08|P-value:2.25E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.64|P-value:1.60E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:-2.87|P-value:5.42E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.03|P-value:2.81E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-4.74|P-value:2.99E-8 ID:SGTC_875|Compound:0709-0210|FD-Score:3.80|P-value:4.83E-6 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.66|P-value:1.45E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:-2.89|P-value:5.07E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.92|P-value:4.44E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.67|P-value:8.86E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-2.83|P-value:6.34E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.30|P-value:2.46E-13 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.31|P-value:2.34E-13 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:2.67|P-value:8.89E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.40|P-value:3.69E-5 ID:SGTC_1716|Compound:st033144|FD-Score:2.98|P-value:2.50E-4 ID:SGTC_1751|Compound:st044839|FD-Score:4.81|P-value:1.13E-8 ID:SGTC_1758|Compound:st042942|FD-Score:3.00|P-value:2.31E-4 ID:SGTC_2374|Compound:9071832|FD-Score:3.02|P-value:2.09E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:-2.81|P-value:7.03E-4 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:-3.56|P-value:2.48E-5 ID:SGTC_2815|Compound:7968870|FD-Score:-3.47|P-value:3.84E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-3.37|P-value:6.06E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-2.73|P-value:9.42E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.25|P-value:5.37E-10 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:-3.06|P-value:2.41E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.08|P-value:2.25E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.64|P-value:1.60E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:-2.87|P-value:5.42E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.03|P-value:2.81E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-4.74|P-value:2.99E-8 ID:SGTC_875|Compound:0709-0210|FD-Score:3.80|P-value:4.83E-6 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.66|P-value:1.45E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:-2.89|P-value:5.07E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.92|P-value:4.44E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.67|P-value:8.86E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-2.83|P-value:6.34E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.30|P-value:2.46E-13 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.31|P-value:2.34E-13 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:2.67|P-value:8.89E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.40|P-value:3.69E-5 ID:SGTC_1716|Compound:st033144|FD-Score:2.98|P-value:2.50E-4 ID:SGTC_1751|Compound:st044839|FD-Score:4.81|P-value:1.13E-8 ID:SGTC_1758|Compound:st042942|FD-Score:3.00|P-value:2.31E-4 ID:SGTC_2374|Compound:9071832|FD-Score:3.02|P-value:2.09E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:-2.81|P-value:7.03E-4 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:-3.56|P-value:2.48E-5 ID:SGTC_2815|Compound:7968870|FD-Score:-3.47|P-value:3.84E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-3.37|P-value:6.06E-5

Top fitness defect scores for YDL157C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 5.25 5.3 µM 5.37E-10 313 7.77E-8
2 SGTC_1751 st044839 4.81 27.2 µM 1.13E-8 Golgi 6 7.70E-7
3 SGTC_875 0709-0210 3.80 25.7 µM 4.83E-6 fatty acid desaturase (OLE1) 35 7.36E-5
4 SGTC_1635 st007035 3.40 42.4 µM 3.69E-5 257 3.42E-4
5 SGTC_2374 9071832 3.02 200.0 µM 2.09E-4 endomembrane recycling 34 0.00127
6 SGTC_1758 st042942 3.00 75.2 µM 2.31E-4 55 0.00137
7 SGTC_1716 st033144 2.98 30.6 µM 2.50E-4 54 0.00145
8 SGTC_1312 1218-2183 2.67 165.0 µM 8.86E-4 55 0.00379
9 SGTC_1584 6-fluoro-dl-tryptophan 2.67 90.0 µM 8.89E-4 mitochondrial processes 92 0.00380
10 SGTC_2650 prasterone 2.63 100.0 µM 0.00104 40 0.00427
11 SGTC_2107 5363541 2.57 170.2 µM 0.00131 83 0.00510
12 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 2.55 66.5 µM 0.00139 91 0.00534
13 SGTC_1924 st058459 2.52 75.1 µM 0.00155 78 0.00581
14 SGTC_3018 9082602 2.50 49.5 µM 0.00172 126 0.00627
15 SGTC_1203 3992-3522 2.48 103.0 µM 0.00186 136 0.00666
16 SGTC_2644 guaiazulene 2.47 100.0 µM 0.00190 60 0.00677
17 SGTC_1219 1469-0211 2.42 33.1 µM 0.00227 91 0.00776
18 SGTC_2586 curcumin 2.42 80.0 µM 0.00228 iron homeostasis 202 0.00777
19 SGTC_2375 9072683 2.39 200.0 µM 0.00252 mitochondrial processes 149 0.00839
20 SGTC_871 0574-0004 2.38 149.0 µM 0.00267 185 0.00877

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.419 5.42E-143 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.393 1.51E-124 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.387 4.61E-120 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.377 1.00E-113 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.373 1.07E-110 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.362 3.83E-104 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.356 1.34E-100 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.344 5.60E-94 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.343 1.71E-93 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.340 8.03E-92 YDR197W CBS2 hom Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
0.340 1.26E-91 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.340 9.79E-92 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.335 1.35E-88 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.314 1.41E-77 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.311 2.17E-76 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit