YDL169C / UGX2

Protein of unknown function, transcript accumulates in response to any combination of stress conditions

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL169C / UGX2

Click on Significant Values for Screen Details ID:SGTC_138|Compound:0850-0259|FD-Score:-3.51|P-value:1.50E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.19|P-value:5.83E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.03|P-value:9.96E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.59|P-value:1.24E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.16|P-value:6.39E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.62|P-value:1.13E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.04|P-value:9.62E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:4.24|P-value:7.47E-6 ID:SGTC_743|Compound:1275-0778|FD-Score:3.79|P-value:5.55E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:-4.11|P-value:1.17E-5 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.56|P-value:1.43E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.22|P-value:8.13E-6 ID:SGTC_1483|Compound:3453-0561|FD-Score:-3.74|P-value:5.84E-5 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.54|P-value:1.55E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.13|P-value:6.99E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.35|P-value:3.16E-4 ID:SGTC_1777|Compound:st045864|FD-Score:3.74|P-value:6.87E-5 ID:SGTC_1925|Compound:st057770|FD-Score:3.07|P-value:8.77E-4 ID:SGTC_1957|Compound:st077035|FD-Score:3.18|P-value:5.91E-4 ID:SGTC_2134|Compound:5324836|FD-Score:3.48|P-value:1.90E-4 ID:SGTC_2168|Compound:5727979|FD-Score:3.19|P-value:5.74E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.71|P-value:7.61E-5 ID:SGTC_2367|Compound:9070478|FD-Score:4.14|P-value:1.20E-5 ID:SGTC_2443|Compound:5493264|FD-Score:-3.20|P-value:4.84E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.40|P-value:3.56E-6 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.56|P-value:1.39E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-5.80|P-value:1.24E-9 ID:SGTC_2702|Compound:st077768|FD-Score:3.06|P-value:9.18E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.81|P-value:5.00E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.50|P-value:1.82E-4 ID:SGTC_2798|Compound:7813637|FD-Score:4.26|P-value:6.95E-6 ID:SGTC_2800|Compound:7887935|FD-Score:3.39|P-value:2.69E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.05|P-value:8.26E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.14|P-value:6.89E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.20|P-value:5.55E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.70|P-value:8.08E-5 ID:SGTC_3143|Compound:9086658|FD-Score:4.72|P-value:7.22E-7 ID:SGTC_3157|Compound:9099274|FD-Score:-3.59|P-value:1.08E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.51|P-value:1.50E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.19|P-value:5.83E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.03|P-value:9.96E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.59|P-value:1.24E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.16|P-value:6.39E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.62|P-value:1.13E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.04|P-value:9.62E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:4.24|P-value:7.47E-6 ID:SGTC_743|Compound:1275-0778|FD-Score:3.79|P-value:5.55E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:-4.11|P-value:1.17E-5 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.56|P-value:1.43E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.22|P-value:8.13E-6 ID:SGTC_1483|Compound:3453-0561|FD-Score:-3.74|P-value:5.84E-5 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.54|P-value:1.55E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.13|P-value:6.99E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.35|P-value:3.16E-4 ID:SGTC_1777|Compound:st045864|FD-Score:3.74|P-value:6.87E-5 ID:SGTC_1925|Compound:st057770|FD-Score:3.07|P-value:8.77E-4 ID:SGTC_1957|Compound:st077035|FD-Score:3.18|P-value:5.91E-4 ID:SGTC_2134|Compound:5324836|FD-Score:3.48|P-value:1.90E-4 ID:SGTC_2168|Compound:5727979|FD-Score:3.19|P-value:5.74E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.71|P-value:7.61E-5 ID:SGTC_2367|Compound:9070478|FD-Score:4.14|P-value:1.20E-5 ID:SGTC_2443|Compound:5493264|FD-Score:-3.20|P-value:4.84E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.40|P-value:3.56E-6 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.56|P-value:1.39E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-5.80|P-value:1.24E-9 ID:SGTC_2702|Compound:st077768|FD-Score:3.06|P-value:9.18E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.81|P-value:5.00E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.50|P-value:1.82E-4 ID:SGTC_2798|Compound:7813637|FD-Score:4.26|P-value:6.95E-6 ID:SGTC_2800|Compound:7887935|FD-Score:3.39|P-value:2.69E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.05|P-value:8.26E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.14|P-value:6.89E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.20|P-value:5.55E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.70|P-value:8.08E-5 ID:SGTC_3143|Compound:9086658|FD-Score:4.72|P-value:7.22E-7 ID:SGTC_3157|Compound:9099274|FD-Score:-3.59|P-value:1.08E-4

Top fitness defect scores for YDL169C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3143 9086658 4.72 49.5 µM 7.22E-7 22 1.18E-6
2 SGTC_2560 caryophyllene 4.40 100.0 µM 3.56E-6 10 5.46E-6
3 SGTC_2798 7813637 4.26 45.5 µM 6.95E-6 23 1.03E-5
4 SGTC_733 4069-0007 4.24 56.1 µM 7.47E-6 ERAD & cell cycle 76 1.11E-5
5 SGTC_1459 k035-0031 4.22 35.7 µM 8.13E-6 DNA intercalators 19 1.20E-5
6 SGTC_2367 9070478 4.14 135.4 µM 1.20E-5 cell wall 28 1.74E-5
7 SGTC_2710 st078562 3.81 53.7 µM 5.00E-5 20 6.85E-5
8 SGTC_743 1275-0778 3.79 158.0 µM 5.55E-5 excess fatty acid 37 7.57E-5
9 SGTC_1777 st045864 3.74 34.8 µM 6.87E-5 14 9.29E-5
10 SGTC_2182 6325192 3.71 200.0 µM 7.61E-5 Golgi 19 1.02E-4
11 SGTC_3020 9089140 3.70 49.5 µM 8.08E-5 34 1.08E-4
12 SGTC_520 3584-0023 3.62 682.0 µM 1.13E-4 33 1.49E-4
13 SGTC_381 3461-2219 3.59 42.7 µM 1.24E-4 copper-dependent oxidative stress 25 1.63E-4
14 SGTC_2689 tacrolimus 3.56 100.0 µM 1.39E-4 63 1.82E-4
15 SGTC_1025 k007-0731 3.56 70.0 µM 1.43E-4 23 1.88E-4
16 SGTC_1596 piperlongumine 3.54 63.0 µM 1.55E-4 26 2.03E-4
17 SGTC_2758 dehydroepiandrosterone 3.50 69.3 µM 1.82E-4 56 2.37E-4
18 SGTC_2134 5324836 3.48 1.5 µM 1.90E-4 26 2.46E-4
19 SGTC_2800 7887935 3.39 81.8 µM 2.69E-4 RPP1 & pyrimidine depletion 57 3.44E-4
20 SGTC_1753 st043925 3.35 64.0 µM 3.16E-4 20 4.01E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 1.97E-13 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.113 4.47E-11 YGL215W CLG1 hom Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2
0.112 7.53E-11 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.111 9.87E-11 YKL021C MAK11 het Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
0.102 3.20E-9 YDR346C SVF1 hom Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance
0.101 4.15E-9 YDL164C CDC9 het DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
0.097 1.52E-8 YJR078W BNA2 hom Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp
0.097 1.75E-8 YAL016C-B_d YAL016C-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.096 2.46E-8 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.091 1.44E-7 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.090 1.56E-7 YGL103W RPL28 het Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance
0.089 2.46E-7 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.087 4.30E-7 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.085 9.03E-7 YDR132C YDR132C hom Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication
0.084 1.24E-6 YPL043W NOP4 het Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)