YDL174C / DLD1

D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL174C / DLD1

Click on Significant Values for Screen Details ID:SGTC_438|Compound:sphingosine|FD-Score:-3.25|P-value:1.11E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:2.78|P-value:8.16E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-2.95|P-value:3.98E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.12|P-value:2.04E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.19|P-value:1.52E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.38|P-value:6.50E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.47|P-value:2.64E-10 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.61|P-value:2.22E-5 ID:SGTC_1695|Compound:st026914|FD-Score:-2.72|P-value:9.83E-4 ID:SGTC_1850|Compound:st056238|FD-Score:-2.91|P-value:4.69E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-2.75|P-value:8.71E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.66|P-value:1.59E-5 ID:SGTC_2415|Compound:st077333|FD-Score:4.97|P-value:9.16E-9 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.19|P-value:1.44E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:2.87|P-value:5.87E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.53|P-value:2.96E-5 ID:SGTC_2624|Compound:nerol|FD-Score:2.85|P-value:6.44E-4 ID:SGTC_2692|Compound:st077426|FD-Score:2.90|P-value:5.08E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.28|P-value:1.01E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.03|P-value:2.91E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:-2.83|P-value:6.37E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-2.86|P-value:5.71E-4 ID:SGTC_2871|Compound:9038510|FD-Score:2.95|P-value:4.19E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-2.79|P-value:7.41E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.25|P-value:1.11E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:2.78|P-value:8.16E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-2.95|P-value:3.98E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.12|P-value:2.04E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.19|P-value:1.52E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.38|P-value:6.50E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.47|P-value:2.64E-10 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.61|P-value:2.22E-5 ID:SGTC_1695|Compound:st026914|FD-Score:-2.72|P-value:9.83E-4 ID:SGTC_1850|Compound:st056238|FD-Score:-2.91|P-value:4.69E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-2.75|P-value:8.71E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.66|P-value:1.59E-5 ID:SGTC_2415|Compound:st077333|FD-Score:4.97|P-value:9.16E-9 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.19|P-value:1.44E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:2.87|P-value:5.87E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.53|P-value:2.96E-5 ID:SGTC_2624|Compound:nerol|FD-Score:2.85|P-value:6.44E-4 ID:SGTC_2692|Compound:st077426|FD-Score:2.90|P-value:5.08E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.28|P-value:1.01E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.03|P-value:2.91E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:-2.83|P-value:6.37E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-2.86|P-value:5.71E-4 ID:SGTC_2871|Compound:9038510|FD-Score:2.95|P-value:4.19E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-2.79|P-value:7.41E-4

Top fitness defect scores for YDL174C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2415 st077333 4.97 57.7 µM 9.16E-9 18 3.37E-7
2 SGTC_1507 4075-3230 3.61 155.0 µM 2.22E-5 15 1.55E-4
3 SGTC_1059 3448-6867 3.38 171.0 µM 6.50E-5 26 3.61E-4
4 SGTC_2693 st077581 3.28 40.7 µM 1.01E-4 67 5.11E-4
5 SGTC_965 1291-5240 3.19 308.0 µM 1.52E-4 58 7.07E-4
6 SGTC_917 harmaline 3.12 728.1 nM 2.04E-4 ergosterol biosynthesis 64 8.92E-4
7 SGTC_2871 9038510 2.95 13.0 µM 4.19E-4 60 0.00158
8 SGTC_2692 st077426 2.90 47.7 µM 5.08E-4 76 0.00184
9 SGTC_2514 salinomycin 2.87 42.7 µM 5.87E-4 115 0.00206
10 SGTC_2624 nerol 2.85 100.0 µM 6.44E-4 53 0.00222
11 SGTC_640 3381-0960 2.78 37.1 µM 8.16E-4 58 0.00268
12 SGTC_713 1488-1073 2.69 324.0 µM 0.00115 ERG2 54 0.00353
13 SGTC_2458 5808907 2.66 16.4 µM 0.00132 50 0.00392
14 SGTC_3313 9133968 2.60 57.0 µM 0.00165 68 0.00468
15 SGTC_1266 0828-0227 2.59 32.9 µM 0.00168 104 0.00474
16 SGTC_2568 diosmetin 2.58 100.0 µM 0.00173 110 0.00487
17 SGTC_1230 0170-0365 2.57 3.8 µM 0.00181 endomembrane recycling 213 0.00504
18 SGTC_2876 9059903 2.56 26.0 µM 0.00188 86 0.00520
19 SGTC_2103 5378138 2.53 10.0 µM 0.00211 111 0.00569
20 SGTC_1741 st038134 2.53 10.2 µM 0.00211 137 0.00570

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.334 4.41E-88 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.317 4.05E-79 YER030W CHZ1 hom Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress
0.290 3.10E-66 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.285 1.07E-63 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.256 3.12E-51 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.229 5.28E-41 YJR092W BUD4 hom Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p
0.218 2.53E-37 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.212 2.26E-35 YGR189C CRH1 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress
0.210 7.32E-35 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.209 2.18E-34 YFR039C_p YFR039C_p hom Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces
0.203 1.45E-32 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.201 5.40E-32 YPR010C RPA135 het RNA polymerase I second largest subunit A135
0.196 2.50E-30 YLR272C YCS4 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.193 1.74E-29 YBR294W SUL1 hom High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.193 1.74E-29 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W