YDL179W / PCL9

Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL179W / PCL9

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.26|P-value:6.40E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.66|P-value:1.44E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.92|P-value:4.39E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.51|P-value:2.56E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-4.41|P-value:5.19E-6 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.28|P-value:5.11E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.33|P-value:4.89E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.54|P-value:2.31E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.79|P-value:8.67E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.11|P-value:9.21E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-3.58|P-value:1.68E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.11|P-value:9.23E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.71|P-value:1.02E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.69|P-value:1.31E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:-3.95|P-value:3.80E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.15|P-value:9.05E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.31|P-value:9.65E-6 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.52|P-value:2.48E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:-3.36|P-value:3.74E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-3.38|P-value:3.55E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.20|P-value:7.82E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-3.30|P-value:4.67E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.54|P-value:1.97E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.72|P-value:1.15E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.26|P-value:5.52E-4 ID:SGTC_1944|Compound:st076371|FD-Score:4.80|P-value:9.81E-7 ID:SGTC_1945|Compound:st075991|FD-Score:4.46|P-value:5.02E-6 ID:SGTC_1948|Compound:st076329|FD-Score:3.53|P-value:2.41E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-5.31|P-value:5.43E-8 ID:SGTC_1953|Compound:st076800|FD-Score:-3.57|P-value:1.75E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-4.41|P-value:5.21E-6 ID:SGTC_2014|Compound:4013930|FD-Score:3.71|P-value:1.21E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.19|P-value:8.15E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:9.06|P-value:1.10E-19 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.64|P-value:2.16E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.09|P-value:9.90E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.19|P-value:8.11E-4 ID:SGTC_2700|Compound:st077718|FD-Score:4.90|P-value:6.05E-7 ID:SGTC_2784|Compound:7567673|FD-Score:4.46|P-value:4.85E-6 ID:SGTC_2824|Compound:7998404|FD-Score:-4.00|P-value:3.05E-5 ID:SGTC_11|Compound:0438-0307|FD-Score:3.26|P-value:6.40E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.66|P-value:1.44E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.92|P-value:4.39E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.51|P-value:2.56E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-4.41|P-value:5.19E-6 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.28|P-value:5.11E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.33|P-value:4.89E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.54|P-value:2.31E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.79|P-value:8.67E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.11|P-value:9.21E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-3.58|P-value:1.68E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.11|P-value:9.23E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.71|P-value:1.02E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.69|P-value:1.31E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:-3.95|P-value:3.80E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.15|P-value:9.05E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.31|P-value:9.65E-6 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.52|P-value:2.48E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:-3.36|P-value:3.74E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-3.38|P-value:3.55E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.20|P-value:7.82E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-3.30|P-value:4.67E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.54|P-value:1.97E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.72|P-value:1.15E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.26|P-value:5.52E-4 ID:SGTC_1944|Compound:st076371|FD-Score:4.80|P-value:9.81E-7 ID:SGTC_1945|Compound:st075991|FD-Score:4.46|P-value:5.02E-6 ID:SGTC_1948|Compound:st076329|FD-Score:3.53|P-value:2.41E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-5.31|P-value:5.43E-8 ID:SGTC_1953|Compound:st076800|FD-Score:-3.57|P-value:1.75E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-4.41|P-value:5.21E-6 ID:SGTC_2014|Compound:4013930|FD-Score:3.71|P-value:1.21E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.19|P-value:8.15E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:9.06|P-value:1.10E-19 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.64|P-value:2.16E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.09|P-value:9.90E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.19|P-value:8.11E-4 ID:SGTC_2700|Compound:st077718|FD-Score:4.90|P-value:6.05E-7 ID:SGTC_2784|Compound:7567673|FD-Score:4.46|P-value:4.85E-6 ID:SGTC_2824|Compound:7998404|FD-Score:-4.00|P-value:3.05E-5

Top fitness defect scores for YDL179W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2586 curcumin 9.06 80.0 µM 1.10E-19 iron homeostasis 3 6.37E-20
2 SGTC_2700 st077718 4.90 96.8 µM 6.05E-7 3 4.88E-7
3 SGTC_1944 st076371 4.80 56.9 µM 9.81E-7 12 7.96E-7
4 SGTC_2587 piperic acid 4.64 92.2 µM 2.16E-6 9 1.77E-6
5 SGTC_2784 7567673 4.46 72.7 µM 4.85E-6 iron homeostasis 20 4.02E-6
6 SGTC_1945 st075991 4.46 56.6 µM 5.02E-6 60S ribosome export 8 4.16E-6
7 SGTC_1258 0671-0043 4.31 57.1 µM 9.65E-6 16 8.07E-6
8 SGTC_816 0325-0417 3.79 81.3 µM 8.67E-5 14 7.46E-5
9 SGTC_1728 st035614 3.72 33.8 µM 1.15E-4 63 9.96E-5
10 SGTC_2014 4013930 3.71 200.0 µM 1.21E-4 44 1.05E-4
11 SGTC_1052 3253-3998 3.69 198.0 µM 1.31E-4 25 1.13E-4
12 SGTC_50 0929-0078 3.66 56.4 µM 1.44E-4 58 1.25E-4
13 SGTC_815 1582-0027 3.54 36.9 µM 2.31E-4 45 2.01E-4
14 SGTC_1948 st076329 3.53 66.6 µM 2.41E-4 42 2.10E-4
15 SGTC_1290 0986-0249 3.52 10.2 µM 2.48E-4 DNA intercalators 33 2.17E-4
16 SGTC_217 ketoconazole 3.51 989.0 nM 2.56E-4 ergosterol depletion effects on membrane 41 2.23E-4
17 SGTC_511 blebbistatin 3.33 171.0 µM 4.89E-4 DNA intercalators 33 4.30E-4
18 SGTC_11 0438-0307 3.26 1.3 µM 6.40E-4 25 5.65E-4
19 SGTC_1656 st012921 3.20 11.0 µM 7.82E-4 54 6.93E-4
20 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 3.19 100.0 µM 8.11E-4 51 7.18E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.176 1.09E-24 YDR286C_p YDR286C_p hom Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site
0.114 3.99E-11 YER150W SPI1 hom GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
0.099 8.51E-9 YOL079W_d YOL079W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.099 8.82E-9 YDL180W_p YDL180W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.095 3.15E-8 YOL124C TRM11 hom Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
0.092 1.02E-7 YDR400W URH1 hom Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways
0.091 1.47E-7 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.089 2.40E-7 YER015W FAA2 hom Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome
0.089 2.58E-7 YNL270C ALP1 hom Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication
0.084 1.12E-6 YER006W NUG1 het GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus
0.084 1.22E-6 YBR248C HIS7 hom Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor
0.083 1.44E-6 YOR131C YOR131C hom Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress
0.082 1.85E-6 YHL015W-A_p YHL015W-A_p hom Putative protein of unknown function
0.082 2.12E-6 YDR513W GRX2 hom Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication
0.082 2.13E-6 YNL172W APC1 het Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress