YDL194W / SNF3

Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL194W / SNF3

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:3.17|P-value:5.09E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:6.28|P-value:4.15E-11 ID:SGTC_67|Compound:0335-0847|FD-Score:6.96|P-value:3.16E-13 ID:SGTC_86|Compound:0417-1630|FD-Score:3.04|P-value:8.14E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.55|P-value:1.21E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.04|P-value:8.16E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.40|P-value:2.66E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:3.07|P-value:7.50E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:3.86|P-value:3.18E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:6.16|P-value:9.79E-11 ID:SGTC_251|Compound:melphalan|FD-Score:4.33|P-value:3.72E-6 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.19|P-value:4.78E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:4.71|P-value:5.55E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:3.48|P-value:1.57E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:-4.10|P-value:1.19E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.19|P-value:5.09E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.81|P-value:3.35E-7 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.04|P-value:8.68E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.26|P-value:5.26E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:3.13|P-value:5.87E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.67|P-value:6.86E-7 ID:SGTC_821|Compound:1114-0266|FD-Score:-3.08|P-value:7.53E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:-3.09|P-value:7.35E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.44|P-value:2.36E-6 ID:SGTC_911|Compound:3456-4043|FD-Score:3.05|P-value:8.09E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.95|P-value:2.38E-5 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.00|P-value:9.41E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.13|P-value:5.99E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:5.50|P-value:6.61E-9 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-3.70|P-value:6.97E-5 ID:SGTC_1089|Compound:terbinafine|FD-Score:-4.77|P-value:4.55E-7 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.64|P-value:8.36E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.79|P-value:4.40E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:-3.20|P-value:4.93E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:-5.44|P-value:1.02E-8 ID:SGTC_1155|Compound:4088-0394|FD-Score:-3.16|P-value:5.81E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.49|P-value:9.91E-12 ID:SGTC_1162|Compound:k048-0130|FD-Score:4.19|P-value:7.26E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.14|P-value:6.06E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.35|P-value:2.87E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.02|P-value:1.63E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.18|P-value:5.31E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:-3.43|P-value:2.07E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.58|P-value:1.05E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.97|P-value:1.97E-5 ID:SGTC_1567|Compound:st069303|FD-Score:3.57|P-value:1.10E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.16|P-value:5.45E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.13|P-value:5.67E-8 ID:SGTC_1732|Compound:st034308|FD-Score:3.04|P-value:8.31E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.37|P-value:2.40E-4 ID:SGTC_1762|Compound:st045503|FD-Score:-3.03|P-value:9.23E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.85|P-value:3.72E-5 ID:SGTC_1765|Compound:st044815|FD-Score:3.14|P-value:5.78E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.89|P-value:2.15E-7 ID:SGTC_2132|Compound:5317594|FD-Score:-4.48|P-value:1.98E-6 ID:SGTC_2424|Compound:5537928|FD-Score:7.15|P-value:7.50E-14 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.81|P-value:4.07E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.00|P-value:3.38E-30 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.82|P-value:4.26E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:4.81|P-value:3.21E-7 ID:SGTC_2963|Compound:9082507|FD-Score:3.46|P-value:1.72E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.29|P-value:3.27E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.08|P-value:7.12E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.17|P-value:5.09E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:6.28|P-value:4.15E-11 ID:SGTC_67|Compound:0335-0847|FD-Score:6.96|P-value:3.16E-13 ID:SGTC_86|Compound:0417-1630|FD-Score:3.04|P-value:8.14E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.55|P-value:1.21E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.04|P-value:8.16E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.40|P-value:2.66E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:3.07|P-value:7.50E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:3.86|P-value:3.18E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:6.16|P-value:9.79E-11 ID:SGTC_251|Compound:melphalan|FD-Score:4.33|P-value:3.72E-6 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.19|P-value:4.78E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:4.71|P-value:5.55E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:3.48|P-value:1.57E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:-4.10|P-value:1.19E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.19|P-value:5.09E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.81|P-value:3.35E-7 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.04|P-value:8.68E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.26|P-value:5.26E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:3.13|P-value:5.87E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.67|P-value:6.86E-7 ID:SGTC_821|Compound:1114-0266|FD-Score:-3.08|P-value:7.53E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:-3.09|P-value:7.35E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.44|P-value:2.36E-6 ID:SGTC_911|Compound:3456-4043|FD-Score:3.05|P-value:8.09E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.95|P-value:2.38E-5 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.00|P-value:9.41E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.13|P-value:5.99E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:5.50|P-value:6.61E-9 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-3.70|P-value:6.97E-5 ID:SGTC_1089|Compound:terbinafine|FD-Score:-4.77|P-value:4.55E-7 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.64|P-value:8.36E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.79|P-value:4.40E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:-3.20|P-value:4.93E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:-5.44|P-value:1.02E-8 ID:SGTC_1155|Compound:4088-0394|FD-Score:-3.16|P-value:5.81E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.49|P-value:9.91E-12 ID:SGTC_1162|Compound:k048-0130|FD-Score:4.19|P-value:7.26E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.14|P-value:6.06E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.35|P-value:2.87E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.02|P-value:1.63E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.18|P-value:5.31E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:-3.43|P-value:2.07E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.58|P-value:1.05E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.97|P-value:1.97E-5 ID:SGTC_1567|Compound:st069303|FD-Score:3.57|P-value:1.10E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.16|P-value:5.45E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.13|P-value:5.67E-8 ID:SGTC_1732|Compound:st034308|FD-Score:3.04|P-value:8.31E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.37|P-value:2.40E-4 ID:SGTC_1762|Compound:st045503|FD-Score:-3.03|P-value:9.23E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.85|P-value:3.72E-5 ID:SGTC_1765|Compound:st044815|FD-Score:3.14|P-value:5.78E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.89|P-value:2.15E-7 ID:SGTC_2132|Compound:5317594|FD-Score:-4.48|P-value:1.98E-6 ID:SGTC_2424|Compound:5537928|FD-Score:7.15|P-value:7.50E-14 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.81|P-value:4.07E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.00|P-value:3.38E-30 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.82|P-value:4.26E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:4.81|P-value:3.21E-7 ID:SGTC_2963|Compound:9082507|FD-Score:3.46|P-value:1.72E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.29|P-value:3.27E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.08|P-value:7.12E-4

Top fitness defect scores for YDL194W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 11.00 100.0 µM 3.38E-30 redox potentiating 51 2.04E-28
2 SGTC_2424 5537928 7.15 59.2 µM 7.50E-14 2 4.43E-13
3 SGTC_67 0335-0847 6.96 266.0 µM 3.16E-13 ubiquinone biosynthesis & proteasome 52 1.71E-12
4 SGTC_1161 k007-0610 6.49 110.0 µM 9.91E-12 ERAD & cell cycle 54 4.33E-11
5 SGTC_64 000l-0018 6.28 272.1 µM 4.15E-11 ubiquinone biosynthesis & proteasome 73 1.66E-10
6 SGTC_216 k038-0035 6.16 28.4 µM 9.79E-11 ubiquinone biosynthesis & proteasome 19 3.72E-10
7 SGTC_1069 diphenylcyclopropenone 5.50 8.5 µM 6.61E-9 10 1.94E-8
8 SGTC_1712 st032288 5.13 53.4 µM 5.67E-8 calcium & mitochondrial duress 111 1.46E-7
9 SGTC_1789 tunicamycin 4.89 25.0 nM 2.15E-7 unfolded protein response 27 5.10E-7
10 SGTC_2756 carbadox 4.81 75.1 µM 3.21E-7 37 7.42E-7
11 SGTC_435 c-PAF 4.81 6.7 µM 3.35E-7 17 7.72E-7
12 SGTC_262 fenpropimorph 4.71 62.5 µM 5.55E-7 ergosterol depletion effects on membrane 18 1.24E-6
13 SGTC_794 k038-0031 4.67 316.0 µM 6.86E-7 ubiquinone biosynthesis & proteasome 88 1.51E-6
14 SGTC_158 k038-0087 4.40 26.4 µM 2.66E-6 ubiquinone biosynthesis & proteasome 113 5.40E-6
15 SGTC_251 melphalan 4.33 456.5 µM 3.72E-6 DNA damage response 14 7.41E-6
16 SGTC_669 0108-0021 4.26 26.2 µM 5.26E-6 fatty acid desaturase (OLE1) 64 1.03E-5
17 SGTC_1162 k048-0130 4.19 20.1 µM 7.26E-6 Golgi 16 1.39E-5
18 SGTC_1370 2001-0092 4.02 44.6 µM 1.63E-5 34 2.96E-5
19 SGTC_1511 0906-3109 3.97 28.5 µM 1.97E-5 excess fatty acid 47 3.54E-5
20 SGTC_201 4262-0159 3.86 12.8 µM 3.18E-5 ergosterol depletion effects on membrane 48 5.56E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.312 6.31E-77 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.303 2.83E-72 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.290 7.68E-66 YJL169W_d YJL169W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
0.264 2.06E-54 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.262 7.23E-54 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.252 6.38E-50 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.251 2.93E-49 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.247 8.01E-48 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.242 8.60E-46 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.239 6.76E-45 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.238 1.49E-44 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.233 1.10E-42 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.231 4.78E-42 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.229 4.19E-41 YLR238W FAR10 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate
0.228 1.36E-40 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p