YDL213C / NOP6

rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL213C / NOP6

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.67|P-value:1.93E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:12.50|P-value:4.57E-34 ID:SGTC_146|Compound:3448-8650|FD-Score:3.83|P-value:1.04E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.30|P-value:7.07E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:4.37|P-value:1.19E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:3.60|P-value:2.45E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.54|P-value:3.02E-4 ID:SGTC_398|Compound:bronopol|FD-Score:4.07|P-value:4.11E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.38|P-value:5.43E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:-5.17|P-value:3.03E-7 ID:SGTC_703|Compound:3875-0075|FD-Score:3.27|P-value:7.75E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:4.25|P-value:1.96E-5 ID:SGTC_840|Compound:0245-0196|FD-Score:4.07|P-value:4.18E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:3.30|P-value:6.95E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.37|P-value:1.17E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:-4.45|P-value:8.67E-6 ID:SGTC_995|Compound:3931-2021|FD-Score:3.26|P-value:7.97E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.16|P-value:2.88E-5 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:-3.92|P-value:7.80E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.60|P-value:4.40E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:4.51|P-value:6.49E-6 ID:SGTC_1800|Compound:st050079|FD-Score:3.47|P-value:3.92E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.58|P-value:2.65E-4 ID:SGTC_1828|Compound:st055811|FD-Score:-4.40|P-value:1.09E-5 ID:SGTC_1829|Compound:berberine|FD-Score:-3.48|P-value:3.89E-4 ID:SGTC_2308|Compound:7584454|FD-Score:5.35|P-value:1.14E-7 ID:SGTC_2312|Compound:7706453|FD-Score:4.89|P-value:1.14E-6 ID:SGTC_2425|Compound:5628681|FD-Score:4.45|P-value:8.32E-6 ID:SGTC_2436|Compound:5633522|FD-Score:3.65|P-value:2.10E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.24|P-value:2.01E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.06|P-value:2.33E-9 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.73|P-value:1.52E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-4.06|P-value:4.45E-5 ID:SGTC_2877|Compound:9040724|FD-Score:4.07|P-value:4.11E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.33|P-value:6.31E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.08|P-value:3.94E-5 ID:SGTC_3108|Compound:9121785|FD-Score:3.83|P-value:1.04E-4 ID:SGTC_3174|Compound:9107204|FD-Score:-3.65|P-value:2.17E-4 ID:SGTC_3180|Compound:9109287|FD-Score:-3.86|P-value:1.00E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.14|P-value:3.13E-5 ID:SGTC_3264|Compound:9137442|FD-Score:3.53|P-value:3.19E-4 ID:SGTC_3266|Compound:9136860|FD-Score:4.24|P-value:2.05E-5 ID:SGTC_3282|Compound:9108498|FD-Score:-3.53|P-value:3.27E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.67|P-value:1.93E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:12.50|P-value:4.57E-34 ID:SGTC_146|Compound:3448-8650|FD-Score:3.83|P-value:1.04E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.30|P-value:7.07E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:4.37|P-value:1.19E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:3.60|P-value:2.45E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.54|P-value:3.02E-4 ID:SGTC_398|Compound:bronopol|FD-Score:4.07|P-value:4.11E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.38|P-value:5.43E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:-5.17|P-value:3.03E-7 ID:SGTC_703|Compound:3875-0075|FD-Score:3.27|P-value:7.75E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:4.25|P-value:1.96E-5 ID:SGTC_840|Compound:0245-0196|FD-Score:4.07|P-value:4.18E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:3.30|P-value:6.95E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.37|P-value:1.17E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:-4.45|P-value:8.67E-6 ID:SGTC_995|Compound:3931-2021|FD-Score:3.26|P-value:7.97E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.16|P-value:2.88E-5 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:-3.92|P-value:7.80E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.60|P-value:4.40E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:4.51|P-value:6.49E-6 ID:SGTC_1800|Compound:st050079|FD-Score:3.47|P-value:3.92E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.58|P-value:2.65E-4 ID:SGTC_1828|Compound:st055811|FD-Score:-4.40|P-value:1.09E-5 ID:SGTC_1829|Compound:berberine|FD-Score:-3.48|P-value:3.89E-4 ID:SGTC_2308|Compound:7584454|FD-Score:5.35|P-value:1.14E-7 ID:SGTC_2312|Compound:7706453|FD-Score:4.89|P-value:1.14E-6 ID:SGTC_2425|Compound:5628681|FD-Score:4.45|P-value:8.32E-6 ID:SGTC_2436|Compound:5633522|FD-Score:3.65|P-value:2.10E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.24|P-value:2.01E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.06|P-value:2.33E-9 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.73|P-value:1.52E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-4.06|P-value:4.45E-5 ID:SGTC_2877|Compound:9040724|FD-Score:4.07|P-value:4.11E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.33|P-value:6.31E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.08|P-value:3.94E-5 ID:SGTC_3108|Compound:9121785|FD-Score:3.83|P-value:1.04E-4 ID:SGTC_3174|Compound:9107204|FD-Score:-3.65|P-value:2.17E-4 ID:SGTC_3180|Compound:9109287|FD-Score:-3.86|P-value:1.00E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.14|P-value:3.13E-5 ID:SGTC_3264|Compound:9137442|FD-Score:3.53|P-value:3.19E-4 ID:SGTC_3266|Compound:9136860|FD-Score:4.24|P-value:2.05E-5 ID:SGTC_3282|Compound:9108498|FD-Score:-3.53|P-value:3.27E-4

Top fitness defect scores for YDL213C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 12.50 9.0 µM 4.57E-34 cell wall 45 2.46E-36
2 SGTC_2688 kanamycin b 6.06 96.7 µM 2.33E-9 calcium & mitochondrial duress 157 6.82E-10
3 SGTC_2308 7584454 5.35 197.6 µM 1.14E-7 6 4.38E-8
4 SGTC_2312 7706453 4.89 155.7 µM 1.14E-6 16 5.09E-7
5 SGTC_1712 st032288 4.60 53.4 µM 4.40E-6 calcium & mitochondrial duress 137 2.16E-6
6 SGTC_1718 roemerine 4.51 11.9 µM 6.49E-6 redox potentiating 31 3.27E-6
7 SGTC_2425 5628681 4.45 7.8 µM 8.32E-6 11 4.26E-6
8 SGTC_928 2764-0428 4.37 58.7 µM 1.17E-5 cell wall 44 6.13E-6
9 SGTC_180 1486-1293 4.37 102.8 µM 1.19E-5 32 6.27E-6
10 SGTC_792 4534-1957 4.25 155.0 µM 1.96E-5 25 1.06E-5
11 SGTC_2614 arthonioic acid 4.24 13.4 µM 2.01E-5 19 1.09E-5
12 SGTC_3266 9136860 4.24 49.5 µM 2.05E-5 cell wall 41 1.11E-5
13 SGTC_1230 0170-0365 4.16 3.8 µM 2.88E-5 endomembrane recycling 58 1.60E-5
14 SGTC_3201 9113999 4.14 49.5 µM 3.13E-5 30 1.75E-5
15 SGTC_2967 9089538 4.08 49.9 µM 3.94E-5 30 2.24E-5
16 SGTC_398 bronopol 4.07 33.3 µM 4.11E-5 RNA processing & uracil transport 24 2.34E-5
17 SGTC_2877 9040724 4.07 71.4 µM 4.11E-5 6 2.35E-5
18 SGTC_840 0245-0196 4.07 390.0 µM 4.18E-5 10 2.39E-5
19 SGTC_3108 9121785 3.83 49.5 µM 1.04E-4 14 6.30E-5
20 SGTC_146 3448-8650 3.83 53.1 µM 1.04E-4 NEO1-PIK1 146 6.32E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.292 8.79E-67 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.287 8.83E-65 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.281 6.97E-62 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.277 2.76E-60 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.264 1.45E-54 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.261 3.60E-53 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.257 1.04E-51 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.256 1.78E-51 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.246 1.92E-47 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.238 1.32E-44 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.236 9.82E-44 YKL053W_d YKL053W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1
0.233 1.04E-42 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.232 2.97E-42 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.232 3.47E-42 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.229 2.49E-41 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids