YDL214C / PRR2

Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL214C / PRR2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-2.94|P-value:9.61E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.55|P-value:1.03E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.41|P-value:1.61E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:-3.18|P-value:4.03E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:4.29|P-value:3.59E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:-3.49|P-value:1.16E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.55|P-value:9.21E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:3.27|P-value:3.16E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.61|P-value:8.05E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:-3.68|P-value:5.41E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:3.57|P-value:9.70E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.53|P-value:1.11E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.55|P-value:9.13E-5 ID:SGTC_1321|Compound:1326-2144|FD-Score:4.25|P-value:4.44E-6 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.23|P-value:3.73E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.26|P-value:3.74E-6 ID:SGTC_1496|Compound:4469-0713|FD-Score:2.98|P-value:9.35E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.26|P-value:3.00E-4 ID:SGTC_1674|Compound:st016616|FD-Score:4.83|P-value:2.14E-7 ID:SGTC_1683|Compound:st010134|FD-Score:-3.51|P-value:1.08E-4 ID:SGTC_1717|Compound:st033143|FD-Score:4.88|P-value:1.67E-7 ID:SGTC_1892|Compound:st058411|FD-Score:5.73|P-value:9.97E-10 ID:SGTC_1906|Compound:st060206|FD-Score:3.22|P-value:3.83E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.21|P-value:3.60E-4 ID:SGTC_1915|Compound:st067105|FD-Score:4.50|P-value:1.28E-6 ID:SGTC_2087|Compound:5276107|FD-Score:3.20|P-value:4.07E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.87|P-value:2.61E-5 ID:SGTC_2101|Compound:5377231|FD-Score:3.94|P-value:1.94E-5 ID:SGTC_2110|Compound:5483698|FD-Score:-2.99|P-value:8.18E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.25|P-value:3.48E-4 ID:SGTC_2439|Compound:5492030|FD-Score:-3.76|P-value:3.68E-5 ID:SGTC_2467|Compound:5474540|FD-Score:-3.11|P-value:5.21E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.35|P-value:2.36E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.15|P-value:4.92E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.25|P-value:3.38E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:4.48|P-value:1.42E-6 ID:SGTC_2831|Compound:7999036|FD-Score:5.58|P-value:2.59E-9 ID:SGTC_2837|Compound:9008476|FD-Score:3.43|P-value:1.69E-4 ID:SGTC_2894|Compound:9048625|FD-Score:4.23|P-value:4.88E-6 ID:SGTC_2966|Compound:9084041|FD-Score:-3.58|P-value:7.97E-5 ID:SGTC_2972|Compound:9093619|FD-Score:-3.10|P-value:5.34E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-2.96|P-value:8.87E-4 ID:SGTC_3179|Compound:9107801|FD-Score:-3.14|P-value:4.75E-4 ID:SGTC_3185|Compound:9108267|FD-Score:-2.96|P-value:8.88E-4 ID:SGTC_3186|Compound:9110464|FD-Score:-3.33|P-value:2.23E-4 ID:SGTC_3231|Compound:9132313|FD-Score:-3.63|P-value:6.71E-5 ID:SGTC_3250|Compound:9135583|FD-Score:3.02|P-value:8.11E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-2.94|P-value:9.61E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.55|P-value:1.03E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.41|P-value:1.61E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:-3.18|P-value:4.03E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:4.29|P-value:3.59E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:-3.49|P-value:1.16E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.55|P-value:9.21E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:3.27|P-value:3.16E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.61|P-value:8.05E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:-3.68|P-value:5.41E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:3.57|P-value:9.70E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.53|P-value:1.11E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.55|P-value:9.13E-5 ID:SGTC_1321|Compound:1326-2144|FD-Score:4.25|P-value:4.44E-6 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.23|P-value:3.73E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.26|P-value:3.74E-6 ID:SGTC_1496|Compound:4469-0713|FD-Score:2.98|P-value:9.35E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.26|P-value:3.00E-4 ID:SGTC_1674|Compound:st016616|FD-Score:4.83|P-value:2.14E-7 ID:SGTC_1683|Compound:st010134|FD-Score:-3.51|P-value:1.08E-4 ID:SGTC_1717|Compound:st033143|FD-Score:4.88|P-value:1.67E-7 ID:SGTC_1892|Compound:st058411|FD-Score:5.73|P-value:9.97E-10 ID:SGTC_1906|Compound:st060206|FD-Score:3.22|P-value:3.83E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.21|P-value:3.60E-4 ID:SGTC_1915|Compound:st067105|FD-Score:4.50|P-value:1.28E-6 ID:SGTC_2087|Compound:5276107|FD-Score:3.20|P-value:4.07E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.87|P-value:2.61E-5 ID:SGTC_2101|Compound:5377231|FD-Score:3.94|P-value:1.94E-5 ID:SGTC_2110|Compound:5483698|FD-Score:-2.99|P-value:8.18E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.25|P-value:3.48E-4 ID:SGTC_2439|Compound:5492030|FD-Score:-3.76|P-value:3.68E-5 ID:SGTC_2467|Compound:5474540|FD-Score:-3.11|P-value:5.21E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.35|P-value:2.36E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.15|P-value:4.92E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.25|P-value:3.38E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:4.48|P-value:1.42E-6 ID:SGTC_2831|Compound:7999036|FD-Score:5.58|P-value:2.59E-9 ID:SGTC_2837|Compound:9008476|FD-Score:3.43|P-value:1.69E-4 ID:SGTC_2894|Compound:9048625|FD-Score:4.23|P-value:4.88E-6 ID:SGTC_2966|Compound:9084041|FD-Score:-3.58|P-value:7.97E-5 ID:SGTC_2972|Compound:9093619|FD-Score:-3.10|P-value:5.34E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-2.96|P-value:8.87E-4 ID:SGTC_3179|Compound:9107801|FD-Score:-3.14|P-value:4.75E-4 ID:SGTC_3185|Compound:9108267|FD-Score:-2.96|P-value:8.88E-4 ID:SGTC_3186|Compound:9110464|FD-Score:-3.33|P-value:2.23E-4 ID:SGTC_3231|Compound:9132313|FD-Score:-3.63|P-value:6.71E-5 ID:SGTC_3250|Compound:9135583|FD-Score:3.02|P-value:8.11E-4

Top fitness defect scores for YDL214C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1892 st058411 5.73 7.4 µM 9.97E-10 5 5.02E-9
2 SGTC_2831 7999036 5.58 19.5 µM 2.59E-9 9 1.20E-8
3 SGTC_1717 st033143 4.88 58.0 µM 1.67E-7 23 5.38E-7
4 SGTC_1674 st016616 4.83 23.6 µM 2.14E-7 11 6.75E-7
5 SGTC_1915 st067105 4.50 30.6 µM 1.28E-6 RNA pol III & RNase P/MRP 25 3.45E-6
6 SGTC_2760 etidronate 4.48 98.0 µM 1.42E-6 16 3.80E-6
7 SGTC_322 k048-0136 4.29 19.3 µM 3.59E-6 RSC & ERG11 10 8.89E-6
8 SGTC_1321 1326-2144 4.25 215.0 µM 4.44E-6 7 1.08E-5
9 SGTC_2894 9048625 4.23 32.5 µM 4.88E-6 6 1.18E-5
10 SGTC_2101 5377231 3.94 179.2 µM 1.94E-5 7 4.16E-5
11 SGTC_2094 5332512 3.87 191.7 µM 2.61E-5 26 5.47E-5
12 SGTC_545 4218-0007 3.61 221.0 µM 8.05E-5 36 1.53E-4
13 SGTC_749 1000-0129 3.57 128.0 µM 9.70E-5 amide catabolism 28 1.82E-4
14 SGTC_99 0109-0120 3.55 622.8 µM 1.03E-4 26 1.93E-4
15 SGTC_1229 0139-0193 3.53 12.2 µM 1.11E-4 RSC complex & mRNA processing 20 2.06E-4
16 SGTC_2837 9008476 3.43 45.5 µM 1.69E-4 57 3.02E-4
17 SGTC_2596 sinensetin 3.35 100.0 µM 2.36E-4 58 4.10E-4
18 SGTC_542 3381-0244 3.27 89.3 µM 3.16E-4 70 5.37E-4
19 SGTC_2744 captopril 3.25 92.0 µM 3.38E-4 60S ribosome export 27 5.71E-4
20 SGTC_2326 6164455 3.25 177.6 µM 3.48E-4 mitochondrial processes 50 5.86E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.181 5.09E-26 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.141 1.99E-16 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.131 3.23E-14 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.117 8.95E-12 YDR459C PFA5 hom Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
0.107 5.40E-10 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.106 8.00E-10 YIR020C_p YIR020C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.106 8.16E-10 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.103 2.51E-9 YGR132C PHB1 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.099 9.76E-9 YDR117C TMA64 hom Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity
0.097 1.92E-8 YER011W TIR1 hom Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
0.097 2.16E-8 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.095 3.63E-8 YML020W_p YML020W_p hom Putative protein of unknown function
0.094 4.77E-8 YNL333W SNZ2 hom Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p
0.093 6.44E-8 YMR195W ICY1 hom Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
0.093 7.30E-8 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p