YDL229W / SSB1

Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL229W / SSB1

Click on Significant Values for Screen Details ID:SGTC_78|Compound:0336-0123|FD-Score:-3.20|P-value:1.77E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:4.21|P-value:1.18E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:3.24|P-value:1.41E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.14|P-value:2.17E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:3.16|P-value:1.94E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.73|P-value:1.47E-5 ID:SGTC_419|Compound:nsc-638432|FD-Score:2.98|P-value:4.19E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:2.92|P-value:5.31E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:4.40|P-value:4.07E-7 ID:SGTC_646|Compound:4092-0839|FD-Score:2.91|P-value:5.42E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:-2.85|P-value:7.19E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:-3.28|P-value:1.25E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.92|P-value:5.82E-6 ID:SGTC_763|Compound:3453-1109|FD-Score:2.95|P-value:4.75E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.50|P-value:4.28E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:3.22|P-value:1.54E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.01|P-value:3.71E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.93|P-value:5.35E-6 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.36|P-value:8.43E-5 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.72|P-value:1.55E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:2.82|P-value:7.82E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.17|P-value:1.93E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.37|P-value:4.89E-7 ID:SGTC_1422|Compound:4031-0024|FD-Score:4.58|P-value:1.40E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.52|P-value:4.18E-5 ID:SGTC_1642|Compound:st009582|FD-Score:3.18|P-value:1.83E-4 ID:SGTC_1678|Compound:st019265|FD-Score:2.96|P-value:4.56E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-2.87|P-value:6.69E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.32|P-value:9.70E-5 ID:SGTC_1780|Compound:st038448|FD-Score:4.03|P-value:3.14E-6 ID:SGTC_1781|Compound:st038725|FD-Score:-4.20|P-value:1.30E-6 ID:SGTC_1786|Compound:berberine|FD-Score:-3.02|P-value:3.70E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.50|P-value:4.32E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.10|P-value:2.50E-4 ID:SGTC_2021|Compound:4019055|FD-Score:2.86|P-value:6.77E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.48|P-value:4.81E-5 ID:SGTC_2242|Compound:6630449|FD-Score:-3.42|P-value:6.53E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.94|P-value:5.10E-6 ID:SGTC_2325|Compound:6158266|FD-Score:3.17|P-value:1.93E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.42|P-value:6.46E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.88|P-value:2.32E-8 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.26|P-value:1.27E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.00|P-value:3.84E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.87|P-value:7.54E-6 ID:SGTC_2968|Compound:9090663|FD-Score:3.06|P-value:3.02E-4 ID:SGTC_2973|Compound:9094665|FD-Score:2.95|P-value:4.66E-4 ID:SGTC_3201|Compound:9113999|FD-Score:2.76|P-value:9.68E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.02|P-value:3.62E-4 ID:SGTC_3208|Compound:9114115|FD-Score:2.89|P-value:5.86E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-2.78|P-value:9.34E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.20|P-value:1.77E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:4.21|P-value:1.18E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:3.24|P-value:1.41E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.14|P-value:2.17E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:3.16|P-value:1.94E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.73|P-value:1.47E-5 ID:SGTC_419|Compound:nsc-638432|FD-Score:2.98|P-value:4.19E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:2.92|P-value:5.31E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:4.40|P-value:4.07E-7 ID:SGTC_646|Compound:4092-0839|FD-Score:2.91|P-value:5.42E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:-2.85|P-value:7.19E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:-3.28|P-value:1.25E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.92|P-value:5.82E-6 ID:SGTC_763|Compound:3453-1109|FD-Score:2.95|P-value:4.75E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.50|P-value:4.28E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:3.22|P-value:1.54E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.01|P-value:3.71E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.93|P-value:5.35E-6 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.36|P-value:8.43E-5 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.72|P-value:1.55E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:2.82|P-value:7.82E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.17|P-value:1.93E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.37|P-value:4.89E-7 ID:SGTC_1422|Compound:4031-0024|FD-Score:4.58|P-value:1.40E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.52|P-value:4.18E-5 ID:SGTC_1642|Compound:st009582|FD-Score:3.18|P-value:1.83E-4 ID:SGTC_1678|Compound:st019265|FD-Score:2.96|P-value:4.56E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-2.87|P-value:6.69E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.32|P-value:9.70E-5 ID:SGTC_1780|Compound:st038448|FD-Score:4.03|P-value:3.14E-6 ID:SGTC_1781|Compound:st038725|FD-Score:-4.20|P-value:1.30E-6 ID:SGTC_1786|Compound:berberine|FD-Score:-3.02|P-value:3.70E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.50|P-value:4.32E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.10|P-value:2.50E-4 ID:SGTC_2021|Compound:4019055|FD-Score:2.86|P-value:6.77E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.48|P-value:4.81E-5 ID:SGTC_2242|Compound:6630449|FD-Score:-3.42|P-value:6.53E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.94|P-value:5.10E-6 ID:SGTC_2325|Compound:6158266|FD-Score:3.17|P-value:1.93E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.42|P-value:6.46E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.88|P-value:2.32E-8 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.26|P-value:1.27E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.00|P-value:3.84E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.87|P-value:7.54E-6 ID:SGTC_2968|Compound:9090663|FD-Score:3.06|P-value:3.02E-4 ID:SGTC_2973|Compound:9094665|FD-Score:2.95|P-value:4.66E-4 ID:SGTC_3201|Compound:9113999|FD-Score:2.76|P-value:9.68E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.02|P-value:3.62E-4 ID:SGTC_3208|Compound:9114115|FD-Score:2.89|P-value:5.86E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-2.78|P-value:9.34E-4

Top fitness defect scores for YDL229W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2638 epoxomicin 4.88 18.0 µM 2.32E-8 15 5.41E-7
2 SGTC_1422 4031-0024 4.58 15.5 µM 1.40E-7 iron homeostasis 8 2.29E-6
3 SGTC_606 k015-0008 4.40 38.6 µM 4.07E-7 5 5.40E-6
4 SGTC_1340 1486-1359 4.37 257.0 µM 4.89E-7 10 6.25E-6
5 SGTC_159 3970-0959 4.21 50.0 µM 1.18E-6 67 1.27E-5
6 SGTC_1780 st038448 4.03 24.5 µM 3.14E-6 iron homeostasis 15 2.80E-5
7 SGTC_2247 cerulenin 3.94 830.0 nM 5.10E-6 17 4.13E-5
8 SGTC_1124 fisetin 3.93 1.2 µM 5.35E-6 35 4.29E-5
9 SGTC_381 3461-2219 3.73 42.7 µM 1.47E-5 copper-dependent oxidative stress 22 9.67E-5
10 SGTC_1235 benzylparaben 3.72 21.5 µM 1.55E-5 16 1.01E-4
11 SGTC_768 0384-0033 3.50 77.3 µM 4.28E-5 fatty acid desaturase (OLE1) 106 2.29E-4
12 SGTC_1787 fluconazole 3.50 80.0 µM 4.32E-5 iron homeostasis 44 2.31E-4
13 SGTC_2084 5306078 3.48 60.6 µM 4.81E-5 30 2.52E-4
14 SGTC_1126 isoteolin 3.36 1.0 µM 8.43E-5 55 3.96E-4
15 SGTC_1703 st026983 3.32 48.3 µM 9.70E-5 27 4.43E-4
16 SGTC_2639 lactacystin 3.26 53.0 µM 1.27E-4 51 5.51E-4
17 SGTC_212 3807-4682 3.24 38.8 µM 1.41E-4 tubulin folding & SWR complex 114 6.00E-4
18 SGTC_803 4488-1585 3.22 147.0 µM 1.54E-4 35 6.43E-4
19 SGTC_1642 st009582 3.18 77.7 µM 1.83E-4 RPP1 & pyrimidine depletion 42 7.42E-4
20 SGTC_1338 1486-1223 3.17 76.0 µM 1.93E-4 48 7.72E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.84E-15 YDR001C NTH1 hom Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication
0.118 6.09E-12 YOL032W OPI10 hom Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress
0.112 9.38E-11 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.111 1.35E-10 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.108 2.97E-10 YLL059C_d YLL059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.100 7.73E-9 YGR084C MRP13 hom Mitochondrial ribosomal protein of the small subunit
0.099 1.06E-8 YGR209C TRX2 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.097 1.63E-8 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.096 2.73E-8 YHR063C PAN5 hom 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE
0.095 4.05E-8 YMR193C-A_d YMR193C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.094 4.77E-8 YDL201W TRM8 hom Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.091 1.13E-7 YIL161W_p YIL161W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene
0.090 1.75E-7 YBR270C_p BIT2_p hom Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication
0.090 1.88E-7 YDR446W ECM11 hom Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
0.089 2.30E-7 YJL064W_d YJL064W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1