YDL230W / PTP1

Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL230W / PTP1

Click on Significant Values for Screen Details ID:SGTC_105|Compound:0111-0055|FD-Score:-3.78|P-value:1.11E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.69|P-value:1.75E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:-4.47|P-value:2.77E-7 ID:SGTC_152|Compound:4469-0003|FD-Score:3.52|P-value:4.34E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:3.22|P-value:1.64E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:2.82|P-value:8.36E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:-3.12|P-value:2.35E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.60|P-value:2.91E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.93|P-value:5.76E-6 ID:SGTC_369|Compound:0957-0393|FD-Score:2.80|P-value:9.08E-4 ID:SGTC_394|Compound:menadione|FD-Score:2.81|P-value:8.58E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-2.75|P-value:9.97E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:2.80|P-value:9.04E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:3.38|P-value:8.13E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:4.03|P-value:3.42E-6 ID:SGTC_616|Compound:4092-0450|FD-Score:3.32|P-value:1.06E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-2.93|P-value:4.96E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:2.86|P-value:6.99E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.56|P-value:3.55E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:6.48|P-value:2.23E-13 ID:SGTC_918|Compound:glabranin|FD-Score:3.43|P-value:6.37E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:2.92|P-value:5.72E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.78|P-value:1.10E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.83|P-value:8.83E-6 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.21|P-value:1.60E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.84|P-value:9.02E-15 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.02|P-value:7.83E-12 ID:SGTC_1522|Compound:st012842|FD-Score:-3.21|P-value:1.60E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-3.36|P-value:8.20E-5 ID:SGTC_1710|Compound:st031758|FD-Score:3.22|P-value:1.63E-4 ID:SGTC_1740|Compound:st038286|FD-Score:2.94|P-value:5.14E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-2.89|P-value:6.02E-4 ID:SGTC_2239|Compound:6685329|FD-Score:5.87|P-value:2.68E-11 ID:SGTC_2241|Compound:6772625|FD-Score:-4.06|P-value:2.67E-6 ID:SGTC_2259|Compound:7964009|FD-Score:-2.81|P-value:8.22E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.91|P-value:6.44E-6 ID:SGTC_2475|Compound:5812728|FD-Score:-3.26|P-value:1.25E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.71|P-value:1.76E-5 ID:SGTC_2817|Compound:7995342|FD-Score:-3.48|P-value:4.73E-5 ID:SGTC_3075|Compound:9116269|FD-Score:3.70|P-value:1.80E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-3.98|P-value:4.12E-6 ID:SGTC_3138|Compound:9097216|FD-Score:-3.44|P-value:5.68E-5 ID:SGTC_3320|Compound:9137005|FD-Score:-3.25|P-value:1.31E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-2.85|P-value:6.82E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.78|P-value:1.11E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.69|P-value:1.75E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:-4.47|P-value:2.77E-7 ID:SGTC_152|Compound:4469-0003|FD-Score:3.52|P-value:4.34E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:3.22|P-value:1.64E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:2.82|P-value:8.36E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:-3.12|P-value:2.35E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.60|P-value:2.91E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.93|P-value:5.76E-6 ID:SGTC_369|Compound:0957-0393|FD-Score:2.80|P-value:9.08E-4 ID:SGTC_394|Compound:menadione|FD-Score:2.81|P-value:8.58E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-2.75|P-value:9.97E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:2.80|P-value:9.04E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:3.38|P-value:8.13E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:4.03|P-value:3.42E-6 ID:SGTC_616|Compound:4092-0450|FD-Score:3.32|P-value:1.06E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-2.93|P-value:4.96E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:2.86|P-value:6.99E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.56|P-value:3.55E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:6.48|P-value:2.23E-13 ID:SGTC_918|Compound:glabranin|FD-Score:3.43|P-value:6.37E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:2.92|P-value:5.72E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.78|P-value:1.10E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.83|P-value:8.83E-6 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.21|P-value:1.60E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.84|P-value:9.02E-15 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.02|P-value:7.83E-12 ID:SGTC_1522|Compound:st012842|FD-Score:-3.21|P-value:1.60E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-3.36|P-value:8.20E-5 ID:SGTC_1710|Compound:st031758|FD-Score:3.22|P-value:1.63E-4 ID:SGTC_1740|Compound:st038286|FD-Score:2.94|P-value:5.14E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-2.89|P-value:6.02E-4 ID:SGTC_2239|Compound:6685329|FD-Score:5.87|P-value:2.68E-11 ID:SGTC_2241|Compound:6772625|FD-Score:-4.06|P-value:2.67E-6 ID:SGTC_2259|Compound:7964009|FD-Score:-2.81|P-value:8.22E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.91|P-value:6.44E-6 ID:SGTC_2475|Compound:5812728|FD-Score:-3.26|P-value:1.25E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.71|P-value:1.76E-5 ID:SGTC_2817|Compound:7995342|FD-Score:-3.48|P-value:4.73E-5 ID:SGTC_3075|Compound:9116269|FD-Score:3.70|P-value:1.80E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-3.98|P-value:4.12E-6 ID:SGTC_3138|Compound:9097216|FD-Score:-3.44|P-value:5.68E-5 ID:SGTC_3320|Compound:9137005|FD-Score:-3.25|P-value:1.31E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-2.85|P-value:6.82E-4

Top fitness defect scores for YDL230W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_916 4466-0038 6.48 42.0 nM 2.23E-13 cell wall 23 4.54E-11
2 SGTC_2239 6685329 5.87 187.6 µM 2.68E-11 3 2.13E-9
3 SGTC_611 3453-1652 4.03 23.7 µM 3.42E-6 14 2.78E-5
4 SGTC_358 0075-0058 3.93 9.4 µM 5.76E-6 64 4.25E-5
5 SGTC_2468 5987765 3.91 72.9 µM 6.44E-6 18 4.65E-5
6 SGTC_2689 tacrolimus 3.71 100.0 µM 1.76E-5 56 1.05E-4
7 SGTC_3075 9116269 3.70 49.5 µM 1.80E-5 27 1.07E-4
8 SGTC_310 1273-0058 3.60 1.1 µM 2.91E-5 mitochondrial stress 276 1.58E-4
9 SGTC_912 3474-0017 3.56 2.2 µM 3.55E-5 33 1.86E-4
10 SGTC_152 4469-0003 3.52 551.2 µM 4.34E-5 34 2.18E-4
11 SGTC_918 glabranin 3.43 770.7 nM 6.37E-5 54 2.98E-4
12 SGTC_603 3794-0023 3.38 45.9 µM 8.13E-5 23 3.63E-4
13 SGTC_616 4092-0450 3.32 108.0 µM 1.06E-4 34 4.50E-4
14 SGTC_1710 st031758 3.22 61.5 µM 1.63E-4 31 6.38E-4
15 SGTC_159 3970-0959 3.22 50.0 µM 1.64E-4 137 6.42E-4
16 SGTC_1740 st038286 2.94 13.2 µM 5.14E-4 81 0.00162
17 SGTC_933 2914-0560 2.92 114.0 µM 5.72E-4 80 0.00177
18 SGTC_910 3454-3003 2.86 490.0 µM 6.99E-4 75 0.00209
19 SGTC_245 methotrexate 2.82 289.6 µM 8.36E-4 105 0.00241
20 SGTC_394 menadione 2.81 8.3 µM 8.58E-4 superoxide 85 0.00246

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.307 3.69E-74 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.295 6.15E-68 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.286 5.52E-64 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.273 1.60E-58 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.270 3.53E-57 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.270 1.36E-56 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.265 6.95E-55 YDL227C HO hom Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p
0.257 8.86E-52 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.248 5.17E-48 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.246 1.32E-47 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.244 1.55E-46 YNL339C YRF1-6 hom Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
0.234 5.31E-43 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.228 6.40E-41 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.226 3.57E-40 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.219 7.31E-38 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2