YDL239C / ADY3

Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL239C / ADY3

Click on Significant Values for Screen Details ID:SGTC_233|Compound:rapamycin|FD-Score:-3.15|P-value:3.71E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.62|P-value:6.42E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:3.04|P-value:6.73E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:4.12|P-value:6.69E-6 ID:SGTC_974|Compound:1326-0144|FD-Score:2.97|P-value:8.58E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-4.14|P-value:4.77E-6 ID:SGTC_983|Compound:1491-0821|FD-Score:4.28|P-value:2.96E-6 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.33|P-value:2.19E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.26|P-value:2.83E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.83|P-value:2.54E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.22|P-value:3.36E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.92|P-value:8.60E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.79|P-value:3.04E-5 ID:SGTC_1756|Compound:st041558|FD-Score:3.69|P-value:4.82E-5 ID:SGTC_1975|Compound:st070967|FD-Score:3.09|P-value:5.50E-4 ID:SGTC_2317|Compound:5986382|FD-Score:3.64|P-value:5.83E-5 ID:SGTC_2326|Compound:6164455|FD-Score:3.49|P-value:1.13E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.52|P-value:1.02E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.36|P-value:1.92E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.51|P-value:7.00E-7 ID:SGTC_2532|Compound:xanthone|FD-Score:-2.94|P-value:8.00E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.01|P-value:7.40E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.05|P-value:5.36E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.14|P-value:4.53E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.04|P-value:9.50E-6 ID:SGTC_2940|Compound:9060638|FD-Score:3.38|P-value:1.80E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.02|P-value:7.07E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.38|P-value:1.77E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:-3.15|P-value:3.71E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.62|P-value:6.42E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:3.04|P-value:6.73E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:4.12|P-value:6.69E-6 ID:SGTC_974|Compound:1326-0144|FD-Score:2.97|P-value:8.58E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-4.14|P-value:4.77E-6 ID:SGTC_983|Compound:1491-0821|FD-Score:4.28|P-value:2.96E-6 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.33|P-value:2.19E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.26|P-value:2.83E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.83|P-value:2.54E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.22|P-value:3.36E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.92|P-value:8.60E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.79|P-value:3.04E-5 ID:SGTC_1756|Compound:st041558|FD-Score:3.69|P-value:4.82E-5 ID:SGTC_1975|Compound:st070967|FD-Score:3.09|P-value:5.50E-4 ID:SGTC_2317|Compound:5986382|FD-Score:3.64|P-value:5.83E-5 ID:SGTC_2326|Compound:6164455|FD-Score:3.49|P-value:1.13E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.52|P-value:1.02E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.36|P-value:1.92E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.51|P-value:7.00E-7 ID:SGTC_2532|Compound:xanthone|FD-Score:-2.94|P-value:8.00E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.01|P-value:7.40E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.05|P-value:5.36E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.14|P-value:4.53E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.04|P-value:9.50E-6 ID:SGTC_2940|Compound:9060638|FD-Score:3.38|P-value:1.80E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.02|P-value:7.07E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.38|P-value:1.77E-4

Top fitness defect scores for YDL239C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_983 1491-0821 4.28 12.2 µM 2.96E-6 11 9.35E-6
2 SGTC_972 1319-0219 4.12 195.0 µM 6.69E-6 24 1.93E-5
3 SGTC_2635 hydroquinidine 4.04 100.0 µM 9.50E-6 23 2.64E-5
4 SGTC_1134 3477-0009 3.83 42.5 µM 2.54E-5 47 6.37E-5
5 SGTC_1520 flindersine 3.79 88.0 µM 3.04E-5 36 7.48E-5
6 SGTC_1756 st041558 3.69 35.5 µM 4.82E-5 15 1.13E-4
7 SGTC_2317 5986382 3.64 200.0 µM 5.83E-5 21 1.34E-4
8 SGTC_382 3229-0966 3.62 23.2 µM 6.42E-5 34 1.46E-4
9 SGTC_2371 9071574 3.52 200.0 µM 1.02E-4 22 2.20E-4
10 SGTC_2326 6164455 3.49 177.6 µM 1.13E-4 mitochondrial processes 41 2.43E-4
11 SGTC_2987 9018338 3.38 71.4 µM 1.77E-4 RPP1 & pyrimidine depletion 41 3.61E-4
12 SGTC_2940 9060638 3.38 45.9 µM 1.80E-4 amide catabolism 47 3.66E-4
13 SGTC_2410 aloe-emodin-8-o-glycoside 3.36 46.3 µM 1.92E-4 mitochondrial processes 58 3.89E-4
14 SGTC_1009 4106-0057 3.33 9.9 µM 2.19E-4 26 4.37E-4
15 SGTC_1066 ketoconazole 3.26 628.0 nM 2.83E-4 48 5.51E-4
16 SGTC_1331 1472-0049 3.22 76.2 µM 3.36E-4 55 6.42E-4
17 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 3.14 100.0 µM 4.53E-4 67 8.38E-4
18 SGTC_1975 st070967 3.09 30.8 µM 5.50E-4 76 9.98E-4
19 SGTC_666 0272-0154 3.04 136.0 µM 6.73E-4 cell wall 102 0.00119
20 SGTC_2942 9052777 3.02 62.2 µM 7.07E-4 82 0.00125

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 1.92E-17 YCR048W ARE1 hom Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication
0.137 1.48E-15 YBL003C HTA2 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.133 1.27E-14 YNL045W LAP2 hom Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.129 8.44E-14 YOR214C_p YOR214C_p hom Putative protein of unknown function; YOR214C is not an essential gene
0.128 1.17E-13 YMR305C SCW10 hom Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
0.118 8.33E-12 YKL128C PMU1 hom Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
0.113 4.70E-11 YIL046W-A_p YIL046W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.111 1.35E-10 YLR406C-A_p YLR406C-A_p hom Putative protein of unknown function
0.095 3.12E-8 YOR083W WHI5 hom Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1
0.094 4.38E-8 YNR003C RPC34 het RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
0.093 6.85E-8 YBL104C SEA4 hom Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites
0.091 1.32E-7 YDR099W BMH2 hom 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.090 1.68E-7 YJR152W DAL5 hom Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
0.090 2.07E-7 YDR279W RNH202 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome
0.088 3.18E-7 YLR287C_p YLR287C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene