YDR003W / RCR2

Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR003W / RCR2

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-3.24|P-value:1.47E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.53|P-value:4.26E-10 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.36|P-value:9.84E-5 ID:SGTC_417|Compound:st075190|FD-Score:3.09|P-value:3.07E-4 ID:SGTC_469|Compound:w7|FD-Score:3.31|P-value:1.24E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:-3.06|P-value:3.15E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.56|P-value:3.99E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:3.12|P-value:2.76E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:2.90|P-value:6.72E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.35|P-value:8.79E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.84|P-value:1.02E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.58|P-value:3.61E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:-3.63|P-value:2.43E-5 ID:SGTC_1498|Compound:4478-3555|FD-Score:3.00|P-value:4.48E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.51|P-value:5.00E-5 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.25|P-value:1.62E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.41|P-value:7.74E-5 ID:SGTC_1952|Compound:st077036|FD-Score:-2.90|P-value:5.78E-4 ID:SGTC_2049|Compound:5262831|FD-Score:4.09|P-value:2.83E-6 ID:SGTC_2165|Compound:5727197|FD-Score:3.68|P-value:2.26E-5 ID:SGTC_2239|Compound:6685329|FD-Score:-2.78|P-value:9.40E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.24|P-value:1.66E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.24|P-value:1.63E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.09|P-value:3.12E-4 ID:SGTC_2923|Compound:7992654|FD-Score:2.97|P-value:4.97E-4 ID:SGTC_2929|Compound:9013348|FD-Score:2.83|P-value:8.65E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-3.55|P-value:3.63E-5 ID:SGTC_2949|Compound:9072542|FD-Score:3.12|P-value:2.69E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.28|P-value:1.42E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.24|P-value:1.47E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.53|P-value:4.26E-10 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.36|P-value:9.84E-5 ID:SGTC_417|Compound:st075190|FD-Score:3.09|P-value:3.07E-4 ID:SGTC_469|Compound:w7|FD-Score:3.31|P-value:1.24E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:-3.06|P-value:3.15E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.56|P-value:3.99E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:3.12|P-value:2.76E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:2.90|P-value:6.72E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.35|P-value:8.79E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.84|P-value:1.02E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.58|P-value:3.61E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:-3.63|P-value:2.43E-5 ID:SGTC_1498|Compound:4478-3555|FD-Score:3.00|P-value:4.48E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.51|P-value:5.00E-5 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.25|P-value:1.62E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.41|P-value:7.74E-5 ID:SGTC_1952|Compound:st077036|FD-Score:-2.90|P-value:5.78E-4 ID:SGTC_2049|Compound:5262831|FD-Score:4.09|P-value:2.83E-6 ID:SGTC_2165|Compound:5727197|FD-Score:3.68|P-value:2.26E-5 ID:SGTC_2239|Compound:6685329|FD-Score:-2.78|P-value:9.40E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.24|P-value:1.66E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.24|P-value:1.63E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.09|P-value:3.12E-4 ID:SGTC_2923|Compound:7992654|FD-Score:2.97|P-value:4.97E-4 ID:SGTC_2929|Compound:9013348|FD-Score:2.83|P-value:8.65E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-3.55|P-value:3.63E-5 ID:SGTC_2949|Compound:9072542|FD-Score:3.12|P-value:2.69E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.28|P-value:1.42E-4

Top fitness defect scores for YDR003W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 5.53 1.1 µM 4.26E-10 mitochondrial stress 160 1.63E-8
2 SGTC_2049 5262831 4.09 67.2 µM 2.83E-6 22 2.13E-5
3 SGTC_1132 3456-3614 3.84 2.5 µM 1.02E-5 tubulin folding & SWR complex 55 6.08E-5
4 SGTC_2165 5727197 3.68 32.1 µM 2.26E-5 45 1.17E-4
5 SGTC_1317 1273-0028 3.58 910.0 nM 3.61E-5 azole & statin 65 1.71E-4
6 SGTC_622 1348-1566 3.56 26.3 µM 3.99E-5 30 1.86E-4
7 SGTC_1500 4488-1866 3.51 171.0 µM 5.00E-5 RPP1 & pyrimidine depletion 32 2.23E-4
8 SGTC_1780 st038448 3.41 24.5 µM 7.74E-5 iron homeostasis 39 3.19E-4
9 SGTC_390 dec-rvkr-cmk 3.36 16.7 µM 9.84E-5 calcium & mitochondrial duress 51 3.89E-4
10 SGTC_469 w7 3.31 172.0 µM 1.24E-4 ERG2 25 4.72E-4
11 SGTC_2951 9072950 3.28 58.1 µM 1.42E-4 ERG2 53 5.26E-4
12 SGTC_1501 4491-0275 3.25 38.4 µM 1.62E-4 27 5.85E-4
13 SGTC_2588 indole-3-carbinol 3.24 100.0 µM 1.63E-4 85 5.90E-4
14 SGTC_2246 7293507 3.24 91.6 µM 1.66E-4 59 5.99E-4
15 SGTC_2949 9072542 3.12 2.2 µM 2.69E-4 TSC3-RPN4 83 8.90E-4
16 SGTC_650 1328-0195 3.12 38.0 µM 2.76E-4 50 9.07E-4
17 SGTC_417 st075190 3.09 100.0 µM 3.07E-4 43 9.92E-4
18 SGTC_2884 9058502 3.09 52.0 µM 3.12E-4 60 0.00101
19 SGTC_1498 4478-3555 3.00 97.6 µM 4.48E-4 23 0.00135
20 SGTC_2923 7992654 2.97 58.1 µM 4.97E-4 Golgi 71 0.00147

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 9.43E-15 YPR130C_d YPR130C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.127 1.40E-13 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.125 4.58E-13 YNL073W MSK1 hom Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)
0.123 8.77E-13 YOR276W CAF20 hom Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E
0.119 5.47E-12 YER028C MIG3 hom Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication
0.116 1.42E-11 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.116 1.86E-11 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.115 2.07E-11 YDR347W MRP1 hom Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein
0.112 9.17E-11 YDR519W FPR2 hom Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress
0.112 9.52E-11 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.111 1.33E-10 YHR040W BCD1 het Essential protein required for the accumulation of box C/D snoRNA
0.110 1.62E-10 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.109 2.59E-10 YMR267W PPA2 hom Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate
0.108 3.45E-10 YOL054W PSH1 hom E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p
0.108 4.16E-10 YDR239C YDR239C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments