YDR017C / KCS1

Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR017C / KCS1

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:3.48|P-value:5.59E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.78|P-value:5.97E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.43|P-value:6.38E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.59|P-value:1.06E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:4.86|P-value:3.46E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:4.09|P-value:6.97E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:3.38|P-value:7.66E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:4.46|P-value:1.75E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:3.42|P-value:6.75E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.17|P-value:1.66E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:7.27|P-value:1.38E-11 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.59|P-value:1.02E-5 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:3.46|P-value:5.93E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-4.95|P-value:9.07E-6 ID:SGTC_502|Compound:l-744,832|FD-Score:4.35|P-value:2.64E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:3.88|P-value:1.45E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.70|P-value:2.72E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:4.39|P-value:2.27E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:3.71|P-value:2.58E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:6.24|P-value:4.93E-9 ID:SGTC_800|Compound:3448-7362|FD-Score:4.94|P-value:2.44E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:5.35|P-value:4.05E-7 ID:SGTC_869|Compound:0564-0080|FD-Score:4.57|P-value:1.11E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.04|P-value:8.27E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.67|P-value:2.97E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.66|P-value:3.05E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.14|P-value:5.88E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:6.51|P-value:1.13E-9 ID:SGTC_1581|Compound:himbacine|FD-Score:4.21|P-value:4.46E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.33|P-value:8.83E-4 ID:SGTC_1745|Compound:st081495|FD-Score:5.83|P-value:3.92E-8 ID:SGTC_1784|Compound:st039334|FD-Score:-3.64|P-value:9.10E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-4.00|P-value:2.90E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-5.21|P-value:3.08E-6 ID:SGTC_1950|Compound:st077106|FD-Score:4.05|P-value:8.01E-5 ID:SGTC_2125|Compound:5246583|FD-Score:-3.97|P-value:3.21E-4 ID:SGTC_2166|Compound:5933061|FD-Score:6.42|P-value:1.83E-9 ID:SGTC_2216|Compound:7189485|FD-Score:4.44|P-value:1.91E-5 ID:SGTC_2274|Compound:7947094|FD-Score:3.39|P-value:7.29E-4 ID:SGTC_2334|Compound:9017922|FD-Score:4.00|P-value:9.83E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.66|P-value:3.07E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:6.91|P-value:1.17E-10 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.81|P-value:5.38E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.64|P-value:3.29E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.45|P-value:6.17E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.38|P-value:7.58E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-3.88|P-value:4.33E-4 ID:SGTC_2827|Compound:7993847|FD-Score:-3.64|P-value:9.32E-4 ID:SGTC_2876|Compound:9059903|FD-Score:-3.83|P-value:5.10E-4 ID:SGTC_2970|Compound:9090938|FD-Score:4.54|P-value:1.26E-5 ID:SGTC_2996|Compound:9066192|FD-Score:9.26|P-value:1.58E-17 ID:SGTC_3149|Compound:9097855|FD-Score:-4.11|P-value:2.01E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.84|P-value:4.92E-4 ID:SGTC_3159|Compound:9100096|FD-Score:4.47|P-value:1.70E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.48|P-value:5.59E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.78|P-value:5.97E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.43|P-value:6.38E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.59|P-value:1.06E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:4.86|P-value:3.46E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:4.09|P-value:6.97E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:3.38|P-value:7.66E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:4.46|P-value:1.75E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:3.42|P-value:6.75E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.17|P-value:1.66E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:7.27|P-value:1.38E-11 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.59|P-value:1.02E-5 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:3.46|P-value:5.93E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-4.95|P-value:9.07E-6 ID:SGTC_502|Compound:l-744,832|FD-Score:4.35|P-value:2.64E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:3.88|P-value:1.45E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.70|P-value:2.72E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:4.39|P-value:2.27E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:3.71|P-value:2.58E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:6.24|P-value:4.93E-9 ID:SGTC_800|Compound:3448-7362|FD-Score:4.94|P-value:2.44E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:5.35|P-value:4.05E-7 ID:SGTC_869|Compound:0564-0080|FD-Score:4.57|P-value:1.11E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.04|P-value:8.27E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.67|P-value:2.97E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.66|P-value:3.05E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.14|P-value:5.88E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:6.51|P-value:1.13E-9 ID:SGTC_1581|Compound:himbacine|FD-Score:4.21|P-value:4.46E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.33|P-value:8.83E-4 ID:SGTC_1745|Compound:st081495|FD-Score:5.83|P-value:3.92E-8 ID:SGTC_1784|Compound:st039334|FD-Score:-3.64|P-value:9.10E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-4.00|P-value:2.90E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-5.21|P-value:3.08E-6 ID:SGTC_1950|Compound:st077106|FD-Score:4.05|P-value:8.01E-5 ID:SGTC_2125|Compound:5246583|FD-Score:-3.97|P-value:3.21E-4 ID:SGTC_2166|Compound:5933061|FD-Score:6.42|P-value:1.83E-9 ID:SGTC_2216|Compound:7189485|FD-Score:4.44|P-value:1.91E-5 ID:SGTC_2274|Compound:7947094|FD-Score:3.39|P-value:7.29E-4 ID:SGTC_2334|Compound:9017922|FD-Score:4.00|P-value:9.83E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.66|P-value:3.07E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:6.91|P-value:1.17E-10 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.81|P-value:5.38E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.64|P-value:3.29E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.45|P-value:6.17E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.38|P-value:7.58E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-3.88|P-value:4.33E-4 ID:SGTC_2827|Compound:7993847|FD-Score:-3.64|P-value:9.32E-4 ID:SGTC_2876|Compound:9059903|FD-Score:-3.83|P-value:5.10E-4 ID:SGTC_2970|Compound:9090938|FD-Score:4.54|P-value:1.26E-5 ID:SGTC_2996|Compound:9066192|FD-Score:9.26|P-value:1.58E-17 ID:SGTC_3149|Compound:9097855|FD-Score:-4.11|P-value:2.01E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.84|P-value:4.92E-4 ID:SGTC_3159|Compound:9100096|FD-Score:4.47|P-value:1.70E-5

Top fitness defect scores for YDR017C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2996 9066192 9.26 71.4 µM 1.58E-17 1 1.01E-20
2 SGTC_467 ro 31-8220 7.27 72.8 µM 1.38E-11 calcium & mitochondrial duress 20 1.77E-13
3 SGTC_2606 farnesol 6.91 9.8 µM 1.17E-10 3 2.36E-12
4 SGTC_1362 1611-0397 6.51 101.0 µM 1.13E-9 1 3.68E-11
5 SGTC_2166 5933061 6.42 31.5 µM 1.83E-9 tubulin folding & SWR complex 12 6.64E-11
6 SGTC_782 0083-0095 6.24 30.5 µM 4.93E-9 3 2.20E-10
7 SGTC_1745 st081495 5.83 74.0 µM 3.92E-8 RNA processing & uracil transport 31 2.70E-9
8 SGTC_832 4083-0019 5.35 164.0 µM 4.05E-7 translation 29 4.51E-8
9 SGTC_800 3448-7362 4.94 155.0 µM 2.44E-6 translation 91 3.89E-7
10 SGTC_168 3970-0862 4.86 530.5 µM 3.46E-6 75 5.93E-7
11 SGTC_475 α-linolenic acid 4.59 10.0 µM 1.02E-5 excess fatty acid 12 2.17E-6
12 SGTC_150 3970-0969 4.59 77.2 µM 1.06E-5 42 2.26E-6
13 SGTC_869 0564-0080 4.57 44.1 µM 1.11E-5 11 2.40E-6
14 SGTC_2970 9090938 4.54 41.9 µM 1.26E-5 RNA processing & uracil transport 21 2.79E-6
15 SGTC_3159 9100096 4.47 49.5 µM 1.70E-5 12 4.00E-6
16 SGTC_214 4373-3496 4.46 70.0 µM 1.75E-5 43 4.13E-6
17 SGTC_2216 7189485 4.44 200.0 µM 1.91E-5 2 4.60E-6
18 SGTC_663 1486-0733 4.39 13.9 µM 2.27E-5 cell wall signaling 41 5.62E-6
19 SGTC_502 l-744,832 4.35 89.3 µM 2.64E-5 calcium & mitochondrial duress 28 6.74E-6
20 SGTC_1581 himbacine 4.21 57.9 µM 4.46E-5 Golgi 45 1.26E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.176 1.02E-24 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.174 3.50E-24 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.138 7.98E-16 YOL049W GSH2 hom Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
0.137 2.05E-15 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.131 2.30E-14 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
0.131 2.73E-14 YBL007C SLA1 hom Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains
0.130 3.68E-14 YGR285C ZUO1 hom Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
0.124 5.31E-13 YBL027W RPL19B hom Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication
0.123 9.65E-13 YDR173C ARG82 hom Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
0.122 1.34E-12 YDL160C DHH1 hom Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress
0.121 1.75E-12 YKL136W_d YKL136W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C
0.121 1.76E-12 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.118 6.58E-12 YGR219W_d YGR219W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C
0.117 1.08E-11 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.117 1.21E-11 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication