YDR019C / GCV1

T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR019C / GCV1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.77|P-value:1.54E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.32|P-value:7.53E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:4.50|P-value:7.94E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:4.25|P-value:2.27E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.43|P-value:5.08E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.24|P-value:9.51E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.97|P-value:7.26E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:3.30|P-value:7.89E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.27|P-value:7.64E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.72|P-value:3.01E-6 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.51|P-value:3.90E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.71|P-value:1.88E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.80|P-value:1.18E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.28|P-value:8.39E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.25|P-value:8.08E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.55|P-value:3.37E-4 ID:SGTC_1667|Compound:st014849|FD-Score:3.84|P-value:1.19E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.26|P-value:8.90E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-5.06|P-value:4.92E-7 ID:SGTC_1982|Compound:st072467|FD-Score:3.48|P-value:4.25E-4 ID:SGTC_2034|Compound:5197015|FD-Score:3.99|P-value:6.60E-5 ID:SGTC_2044|Compound:5102272|FD-Score:3.67|P-value:2.23E-4 ID:SGTC_2112|Compound:5488546|FD-Score:4.85|P-value:1.65E-6 ID:SGTC_2161|Compound:5662504|FD-Score:-3.32|P-value:6.55E-4 ID:SGTC_2191|Compound:5911152|FD-Score:-3.36|P-value:5.62E-4 ID:SGTC_2291|Compound:7917025|FD-Score:4.26|P-value:2.19E-5 ID:SGTC_2439|Compound:5492030|FD-Score:-3.40|P-value:4.92E-4 ID:SGTC_2440|Compound:5628896|FD-Score:3.43|P-value:5.14E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.39|P-value:5.15E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.28|P-value:8.48E-4 ID:SGTC_2818|Compound:7996756|FD-Score:3.45|P-value:4.74E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-7.94|P-value:9.05E-15 ID:SGTC_2823|Compound:7987624|FD-Score:-4.71|P-value:2.62E-6 ID:SGTC_2824|Compound:7998404|FD-Score:5.24|P-value:2.44E-7 ID:SGTC_2877|Compound:9040724|FD-Score:3.60|P-value:2.86E-4 ID:SGTC_2878|Compound:9043973|FD-Score:3.44|P-value:5.03E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.31|P-value:6.73E-4 ID:SGTC_2924|Compound:9010168|FD-Score:4.45|P-value:1.00E-5 ID:SGTC_2934|Compound:9036370|FD-Score:3.33|P-value:7.11E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-5.47|P-value:6.33E-8 ID:SGTC_3151|Compound:9099821|FD-Score:-3.70|P-value:1.71E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-4.75|P-value:2.22E-6 ID:SGTC_6|Compound:0844-0013|FD-Score:3.77|P-value:1.54E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.32|P-value:7.53E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:4.50|P-value:7.94E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:4.25|P-value:2.27E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.43|P-value:5.08E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.24|P-value:9.51E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.97|P-value:7.26E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:3.30|P-value:7.89E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.27|P-value:7.64E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.72|P-value:3.01E-6 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.51|P-value:3.90E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.71|P-value:1.88E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.80|P-value:1.18E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.28|P-value:8.39E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.25|P-value:8.08E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.55|P-value:3.37E-4 ID:SGTC_1667|Compound:st014849|FD-Score:3.84|P-value:1.19E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.26|P-value:8.90E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-5.06|P-value:4.92E-7 ID:SGTC_1982|Compound:st072467|FD-Score:3.48|P-value:4.25E-4 ID:SGTC_2034|Compound:5197015|FD-Score:3.99|P-value:6.60E-5 ID:SGTC_2044|Compound:5102272|FD-Score:3.67|P-value:2.23E-4 ID:SGTC_2112|Compound:5488546|FD-Score:4.85|P-value:1.65E-6 ID:SGTC_2161|Compound:5662504|FD-Score:-3.32|P-value:6.55E-4 ID:SGTC_2191|Compound:5911152|FD-Score:-3.36|P-value:5.62E-4 ID:SGTC_2291|Compound:7917025|FD-Score:4.26|P-value:2.19E-5 ID:SGTC_2439|Compound:5492030|FD-Score:-3.40|P-value:4.92E-4 ID:SGTC_2440|Compound:5628896|FD-Score:3.43|P-value:5.14E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.39|P-value:5.15E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.28|P-value:8.48E-4 ID:SGTC_2818|Compound:7996756|FD-Score:3.45|P-value:4.74E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-7.94|P-value:9.05E-15 ID:SGTC_2823|Compound:7987624|FD-Score:-4.71|P-value:2.62E-6 ID:SGTC_2824|Compound:7998404|FD-Score:5.24|P-value:2.44E-7 ID:SGTC_2877|Compound:9040724|FD-Score:3.60|P-value:2.86E-4 ID:SGTC_2878|Compound:9043973|FD-Score:3.44|P-value:5.03E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.31|P-value:6.73E-4 ID:SGTC_2924|Compound:9010168|FD-Score:4.45|P-value:1.00E-5 ID:SGTC_2934|Compound:9036370|FD-Score:3.33|P-value:7.11E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-5.47|P-value:6.33E-8 ID:SGTC_3151|Compound:9099821|FD-Score:-3.70|P-value:1.71E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-4.75|P-value:2.22E-6

Top fitness defect scores for YDR019C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2824 7998404 5.24 52.0 µM 2.44E-7 11 7.86E-8
2 SGTC_2112 5488546 4.85 200.0 µM 1.65E-6 TSC3-RPN4 10 6.19E-7
3 SGTC_1128 3448-9350 4.72 235.0 µM 3.01E-6 14 1.18E-6
4 SGTC_188 3229-0966 4.50 278.5 µM 7.94E-6 19 3.37E-6
5 SGTC_2924 9010168 4.45 62.8 µM 1.00E-5 cell wall signaling 25 4.33E-6
6 SGTC_2291 7917025 4.26 104.3 µM 2.19E-5 iron homeostasis 40 1.01E-5
7 SGTC_212 3807-4682 4.25 38.8 µM 2.27E-5 tubulin folding & SWR complex 56 1.05E-5
8 SGTC_2034 5197015 3.99 53.1 µM 6.60E-5 SWF1 & branched chain AA biosynthesis 22 3.31E-5
9 SGTC_594 1487-1584 3.97 10.8 µM 7.26E-5 23 3.67E-5
10 SGTC_1667 st014849 3.84 34.6 µM 1.19E-4 Golgi 10 6.27E-5
11 SGTC_6 0844-0013 3.77 19.8 µM 1.54E-4 104 8.26E-5
12 SGTC_1294 1000-1494 3.71 117.0 µM 1.88E-4 29 1.02E-4
13 SGTC_2044 5102272 3.67 200.0 µM 2.23E-4 15 1.24E-4
14 SGTC_2877 9040724 3.60 71.4 µM 2.86E-4 17 1.61E-4
15 SGTC_1483 3453-0561 3.55 55.9 µM 3.37E-4 33 1.92E-4
16 SGTC_1248 0469-0687 3.51 58.6 µM 3.90E-4 44 2.25E-4
17 SGTC_1982 st072467 3.48 71.9 µM 4.25E-4 52 2.47E-4
18 SGTC_2818 7996756 3.45 13.0 µM 4.74E-4 25 2.78E-4
19 SGTC_2878 9043973 3.44 26.0 µM 5.03E-4 33 2.96E-4
20 SGTC_474 dl-dihydrosphingosine 3.43 5.0 µM 5.08E-4 50 3.00E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 3.19E-14 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.125 3.18E-13 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.116 1.36E-11 YDL207W GLE1 het Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
0.115 2.90E-11 YMR235C RNA1 het GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport
0.109 2.68E-10 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.098 1.25E-8 YPR012W_d YPR012W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene
0.098 1.45E-8 YFR042W KEG1 het Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
0.097 1.66E-8 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.092 9.31E-8 YOR381W FRE3 hom Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
0.089 2.73E-7 YKL185W ASH1 hom Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
0.087 4.80E-7 YOL085C_d YOL085C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
0.082 1.71E-6 YPL016W SWI1 het Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer
0.082 2.26E-6 YER159C BUR6 het Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
0.080 3.55E-6 YOL075C_p YOL075C_p hom Putative ABC transporter
0.080 3.84E-6 YLR313C SPH1 hom Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p