HIPHOP chemogenomics database

YDR021W / FAL1

Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases

Zygosity: Heterozygous strain

fixedexpanded
Profile for YDR021W / FAL1

Click on Significant Values for Screen Details

Top fitness defect scores for YDR021W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_1732	st034308	5.71	51.8 µM	2.45E-11		1	5.75E-9	0.44
2	SGTC_184	1494-0393	4.57	24.7 µM	6.78E-8		22	2.39E-6	0.02
3	SGTC_1727	st034309	4.39	9.9 µM	2.08E-7		11	5.63E-6	0.13
4	SGTC_2960	9079389	4.30	6.0 µM	3.50E-7		2	8.37E-6	0.21
5	SGTC_1246	0422-0085	4.23	105.0 µM	5.29E-7		7	1.15E-5	0.03
6	SGTC_2381	9035592	4.17	200.0 µM	7.81E-7		6	1.55E-5	0.32
7	SGTC_764	1951-2361	3.95	146.0 µM	2.61E-6		11	3.88E-5	0.01
8	SGTC_2462	5162487	3.60	171.8 µM	1.61E-5		7	1.56E-4	0.26
9	SGTC_2456	5770359	3.58	74.5 µM	1.79E-5		6	1.69E-4	0.19
10	SGTC_1494	4358-1428	3.50	177.0 µM	2.70E-5		8	2.32E-4	0.04
11	SGTC_2387	9077560	3.27	195.1 µM	7.97E-5		17	5.31E-4	0.01
12	SGTC_1579	chlormadinone acetate	3.14	49.4 µM	1.45E-4		11	8.39E-4	0.03
13	SGTC_3150	9097574	3.07	49.5 µM	2.00E-4		11	0.00108	0.24
14	SGTC_1736	st036774	3.03	51.0 µM	2.35E-4		10	0.00122	0.10
15	SGTC_2958	9077254	3.00	16.7 µM	2.66E-4		16	0.00134	0.14
16	SGTC_1171	0368-0077	2.88	21.4 µM	4.48E-4		33	0.00200	0.00
17	SGTC_740	k014-0057	2.86	261.0 µM	4.76E-4		22	0.00210	0.08
18	SGTC_2574	2',4'-dihydroxychalcone	2.82	14.6 µM	5.79E-4		29	0.00244	0.09
19	SGTC_561	1550-0330	2.79	72.9 µM	6.44E-4		16	0.00265	0.12
20	SGTC_1435	4092-0789	2.78	56.7 µM	6.71E-4	plasma membrane duress	22	0.00273	0.09

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.175	1.66E-24	YBR155W	CNS1	het	TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.170	3.69E-23	YPL035C_d	YPL035C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.135	4.40E-15	YDR478W	SNM1	het	Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.124	5.11E-13	YOR335C	ALA1	het	Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog
0.122	1.54E-12	YDL102W	POL3	het	Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
0.121	1.91E-12	YOR063W	RPL3	het	Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus
0.121	2.25E-12	YHR019C	DED81	het	Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
0.119	4.75E-12	YMR308C	PSE1	het	Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
0.115	2.64E-11	YOR056C	NOB1	het	Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress
0.115	3.11E-11	YPL262W	FUM1	hom	Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.111	1.28E-10	YKL196C	YKT6	het	Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
0.111	1.32E-10	YLR195C	NMT1	het	N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.107	4.99E-10	YDR416W	SYF1	het	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
0.105	1.09E-9	YDL153C	SAS10	het	Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.104	1.47E-9	YDR235W	PRP42	het	U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats