YDR024W_d / FYV1

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR024W / FYV1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.61|P-value:3.65E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:-4.47|P-value:1.20E-5 ID:SGTC_23|Compound:0213-0011|FD-Score:-4.29|P-value:2.50E-5 ID:SGTC_25|Compound:0118-0223|FD-Score:3.94|P-value:1.13E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.40|P-value:1.88E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.50|P-value:4.72E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.53|P-value:4.80E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.39|P-value:7.56E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:4.38|P-value:2.03E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:4.22|P-value:3.82E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:3.99|P-value:9.12E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:-4.79|P-value:3.11E-6 ID:SGTC_572|Compound:0960-0087|FD-Score:3.94|P-value:1.12E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.63|P-value:3.32E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.77|P-value:2.03E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:5.13|P-value:7.44E-7 ID:SGTC_903|Compound:1134-0042|FD-Score:3.57|P-value:4.12E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:-3.78|P-value:1.74E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.83|P-value:1.69E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-4.27|P-value:2.75E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:4.35|P-value:2.29E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:5.07|P-value:9.87E-7 ID:SGTC_1352|Compound:1496-0991|FD-Score:5.20|P-value:5.30E-7 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.54|P-value:4.07E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:-3.50|P-value:4.63E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.42|P-value:6.82E-4 ID:SGTC_1526|Compound:st051518|FD-Score:4.40|P-value:1.87E-5 ID:SGTC_1722|Compound:st034304|FD-Score:3.72|P-value:2.42E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.95|P-value:1.09E-4 ID:SGTC_1863|Compound:st057641|FD-Score:4.14|P-value:5.28E-5 ID:SGTC_1970|Compound:st070122|FD-Score:-3.75|P-value:1.94E-4 ID:SGTC_2053|Compound:5265679|FD-Score:4.34|P-value:2.39E-5 ID:SGTC_2092|Compound:5303694|FD-Score:4.25|P-value:3.34E-5 ID:SGTC_2150|Compound:5556613|FD-Score:4.17|P-value:4.67E-5 ID:SGTC_2152|Compound:5568786|FD-Score:3.54|P-value:4.63E-4 ID:SGTC_2162|Compound:5663267|FD-Score:-4.03|P-value:6.92E-5 ID:SGTC_2452|Compound:5863136|FD-Score:5.53|P-value:1.04E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.98|P-value:8.55E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.87|P-value:1.26E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.42|P-value:1.73E-5 ID:SGTC_2715|Compound:st079500|FD-Score:3.88|P-value:1.41E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-4.46|P-value:1.25E-5 ID:SGTC_2797|Compound:7859098|FD-Score:-4.12|P-value:4.88E-5 ID:SGTC_2803|Compound:7707263|FD-Score:4.93|P-value:1.91E-6 ID:SGTC_2809|Compound:7964133|FD-Score:4.23|P-value:3.63E-5 ID:SGTC_2947|Compound:9072639|FD-Score:3.64|P-value:3.29E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:-3.71|P-value:2.29E-4 ID:SGTC_3072|Compound:9116419|FD-Score:4.31|P-value:2.65E-5 ID:SGTC_3132|Compound:9126706|FD-Score:-3.29|P-value:9.45E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.95|P-value:1.07E-4 ID:SGTC_3328|Compound:9140624|FD-Score:-3.29|P-value:9.42E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.61|P-value:3.65E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:-4.47|P-value:1.20E-5 ID:SGTC_23|Compound:0213-0011|FD-Score:-4.29|P-value:2.50E-5 ID:SGTC_25|Compound:0118-0223|FD-Score:3.94|P-value:1.13E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.40|P-value:1.88E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.50|P-value:4.72E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.53|P-value:4.80E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.39|P-value:7.56E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:4.38|P-value:2.03E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:4.22|P-value:3.82E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:3.99|P-value:9.12E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:-4.79|P-value:3.11E-6 ID:SGTC_572|Compound:0960-0087|FD-Score:3.94|P-value:1.12E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.63|P-value:3.32E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.77|P-value:2.03E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:5.13|P-value:7.44E-7 ID:SGTC_903|Compound:1134-0042|FD-Score:3.57|P-value:4.12E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:-3.78|P-value:1.74E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.83|P-value:1.69E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-4.27|P-value:2.75E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:4.35|P-value:2.29E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:5.07|P-value:9.87E-7 ID:SGTC_1352|Compound:1496-0991|FD-Score:5.20|P-value:5.30E-7 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.54|P-value:4.07E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:-3.50|P-value:4.63E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.42|P-value:6.82E-4 ID:SGTC_1526|Compound:st051518|FD-Score:4.40|P-value:1.87E-5 ID:SGTC_1722|Compound:st034304|FD-Score:3.72|P-value:2.42E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.95|P-value:1.09E-4 ID:SGTC_1863|Compound:st057641|FD-Score:4.14|P-value:5.28E-5 ID:SGTC_1970|Compound:st070122|FD-Score:-3.75|P-value:1.94E-4 ID:SGTC_2053|Compound:5265679|FD-Score:4.34|P-value:2.39E-5 ID:SGTC_2092|Compound:5303694|FD-Score:4.25|P-value:3.34E-5 ID:SGTC_2150|Compound:5556613|FD-Score:4.17|P-value:4.67E-5 ID:SGTC_2152|Compound:5568786|FD-Score:3.54|P-value:4.63E-4 ID:SGTC_2162|Compound:5663267|FD-Score:-4.03|P-value:6.92E-5 ID:SGTC_2452|Compound:5863136|FD-Score:5.53|P-value:1.04E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.98|P-value:8.55E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.87|P-value:1.26E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.42|P-value:1.73E-5 ID:SGTC_2715|Compound:st079500|FD-Score:3.88|P-value:1.41E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-4.46|P-value:1.25E-5 ID:SGTC_2797|Compound:7859098|FD-Score:-4.12|P-value:4.88E-5 ID:SGTC_2803|Compound:7707263|FD-Score:4.93|P-value:1.91E-6 ID:SGTC_2809|Compound:7964133|FD-Score:4.23|P-value:3.63E-5 ID:SGTC_2947|Compound:9072639|FD-Score:3.64|P-value:3.29E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:-3.71|P-value:2.29E-4 ID:SGTC_3072|Compound:9116419|FD-Score:4.31|P-value:2.65E-5 ID:SGTC_3132|Compound:9126706|FD-Score:-3.29|P-value:9.45E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.95|P-value:1.07E-4 ID:SGTC_3328|Compound:9140624|FD-Score:-3.29|P-value:9.42E-4

Top fitness defect scores for YDR024W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2452 5863136 5.53 48.4 µM 1.04E-7 6 1.57E-8
2 SGTC_1352 1496-0991 5.20 99.0 µM 5.30E-7 tubulin folding & SWR complex 9 9.84E-8
3 SGTC_836 0330-0104 5.13 1.4 µM 7.44E-7 5 1.44E-7
4 SGTC_1242 0402-0103 5.07 60.1 µM 9.87E-7 11 1.98E-7
5 SGTC_2803 7707263 4.93 71.4 µM 1.91E-6 17 4.19E-7
6 SGTC_2688 kanamycin b 4.42 96.7 µM 1.73E-5 calcium & mitochondrial duress 305 5.02E-6
7 SGTC_1526 st051518 4.40 75.0 µM 1.87E-5 16 5.48E-6
8 SGTC_146 3448-8650 4.40 53.1 µM 1.88E-5 NEO1-PIK1 115 5.51E-6
9 SGTC_195 4234-0266 4.38 16.6 µM 2.03E-5 21 6.01E-6
10 SGTC_1227 3909-8010 4.35 46.6 µM 2.29E-5 8 6.87E-6
11 SGTC_2053 5265679 4.34 138.0 µM 2.39E-5 16 7.21E-6
12 SGTC_3072 9116419 4.31 49.5 µM 2.65E-5 ERG2 9 8.10E-6
13 SGTC_2092 5303694 4.25 80.7 µM 3.34E-5 TSC3-RPN4 33 1.05E-5
14 SGTC_2809 7964133 4.23 13.0 µM 3.63E-5 60S ribosome export 27 1.16E-5
15 SGTC_363 0455-0021 4.22 3.1 µM 3.82E-5 azole & statin 56 1.22E-5
16 SGTC_2150 5556613 4.17 200.0 µM 4.67E-5 15 1.54E-5
17 SGTC_1863 st057641 4.14 20.1 µM 5.28E-5 11 1.76E-5
18 SGTC_424 splitomicin 3.99 100.0 mM 9.12E-5 20 3.26E-5
19 SGTC_3154 9100113 3.95 49.5 µM 1.07E-4 28 3.90E-5
20 SGTC_1781 st038725 3.95 66.3 µM 1.09E-4 NEO1 99 3.97E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 4.30E-15 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.134 8.49E-15 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.124 5.58E-13 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
0.115 2.73E-11 YDL052C SLC1 hom 1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes
0.106 8.66E-10 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.104 1.62E-9 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.102 3.13E-9 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.101 4.88E-9 YDR471W RPL27B hom Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication
0.100 6.29E-9 YDL136W RPL35B hom Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication
0.097 2.05E-8 YGR214W RPS0A hom Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;
0.096 2.46E-8 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.095 3.69E-8 YEL022W GEA2 hom Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication
0.095 3.76E-8 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.093 6.60E-8 YOR295W UAF30 hom Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication
0.092 1.06E-7 YGR081C SLX9 hom Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant