YDR029W_d

Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR029W / YDR029W

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-5.44|P-value:6.63E-10 ID:SGTC_46|Compound:0329-0187a|FD-Score:6.61|P-value:1.06E-13 ID:SGTC_187|Compound:1488-2104|FD-Score:-3.33|P-value:1.01E-4 ID:SGTC_223|Compound:busulfan|FD-Score:-3.12|P-value:2.47E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:2.91|P-value:6.39E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.16|P-value:1.76E-6 ID:SGTC_321|Compound:4534-3890|FD-Score:2.90|P-value:6.60E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-5.44|P-value:6.69E-10 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.65|P-value:2.29E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:3.32|P-value:1.18E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:2.99|P-value:4.62E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-2.88|P-value:6.52E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:2.86|P-value:7.67E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:2.90|P-value:6.50E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:6.18|P-value:3.56E-12 ID:SGTC_875|Compound:0709-0210|FD-Score:4.13|P-value:2.30E-6 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.99|P-value:4.23E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.83|P-value:1.06E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.51|P-value:5.00E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:2.86|P-value:7.70E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.17|P-value:2.23E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.22|P-value:1.78E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.56|P-value:3.99E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.24|P-value:1.67E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:2.79|P-value:9.87E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-3.11|P-value:2.55E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-3.50|P-value:4.58E-5 ID:SGTC_1619|Compound:st003326|FD-Score:2.96|P-value:5.33E-4 ID:SGTC_1902|Compound:st060212|FD-Score:-2.92|P-value:5.50E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-2.84|P-value:7.55E-4 ID:SGTC_2256|Compound:7954252|FD-Score:3.36|P-value:9.66E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-5.57|P-value:2.68E-10 ID:SGTC_2347|Compound:9049783|FD-Score:3.10|P-value:2.98E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.50|P-value:5.33E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:3.30|P-value:1.26E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:2.87|P-value:7.32E-4 ID:SGTC_2625|Compound:euphol|FD-Score:4.93|P-value:2.23E-8 ID:SGTC_2808|Compound:7946468|FD-Score:-3.33|P-value:1.02E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-2.91|P-value:5.69E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.26|P-value:1.36E-4 ID:SGTC_2955|Compound:9076254|FD-Score:4.18|P-value:1.76E-6 ID:SGTC_3026|Compound:9090633|FD-Score:-2.77|P-value:9.75E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.68|P-value:2.31E-5 ID:SGTC_3192|Compound:9110362|FD-Score:-3.63|P-value:2.48E-5 ID:SGTC_3196|Compound:9111891|FD-Score:-4.62|P-value:1.27E-7 ID:SGTC_44|Compound:0929-0055|FD-Score:-5.44|P-value:6.63E-10 ID:SGTC_46|Compound:0329-0187a|FD-Score:6.61|P-value:1.06E-13 ID:SGTC_187|Compound:1488-2104|FD-Score:-3.33|P-value:1.01E-4 ID:SGTC_223|Compound:busulfan|FD-Score:-3.12|P-value:2.47E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:2.91|P-value:6.39E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.16|P-value:1.76E-6 ID:SGTC_321|Compound:4534-3890|FD-Score:2.90|P-value:6.60E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-5.44|P-value:6.69E-10 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.65|P-value:2.29E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:3.32|P-value:1.18E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:2.99|P-value:4.62E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-2.88|P-value:6.52E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:2.86|P-value:7.67E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:2.90|P-value:6.50E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:6.18|P-value:3.56E-12 ID:SGTC_875|Compound:0709-0210|FD-Score:4.13|P-value:2.30E-6 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.99|P-value:4.23E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.83|P-value:1.06E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.51|P-value:5.00E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:2.86|P-value:7.70E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.17|P-value:2.23E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.22|P-value:1.78E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.56|P-value:3.99E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.24|P-value:1.67E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:2.79|P-value:9.87E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-3.11|P-value:2.55E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-3.50|P-value:4.58E-5 ID:SGTC_1619|Compound:st003326|FD-Score:2.96|P-value:5.33E-4 ID:SGTC_1902|Compound:st060212|FD-Score:-2.92|P-value:5.50E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-2.84|P-value:7.55E-4 ID:SGTC_2256|Compound:7954252|FD-Score:3.36|P-value:9.66E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-5.57|P-value:2.68E-10 ID:SGTC_2347|Compound:9049783|FD-Score:3.10|P-value:2.98E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.50|P-value:5.33E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:3.30|P-value:1.26E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:2.87|P-value:7.32E-4 ID:SGTC_2625|Compound:euphol|FD-Score:4.93|P-value:2.23E-8 ID:SGTC_2808|Compound:7946468|FD-Score:-3.33|P-value:1.02E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-2.91|P-value:5.69E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.26|P-value:1.36E-4 ID:SGTC_2955|Compound:9076254|FD-Score:4.18|P-value:1.76E-6 ID:SGTC_3026|Compound:9090633|FD-Score:-2.77|P-value:9.75E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.68|P-value:2.31E-5 ID:SGTC_3192|Compound:9110362|FD-Score:-3.63|P-value:2.48E-5 ID:SGTC_3196|Compound:9111891|FD-Score:-4.62|P-value:1.27E-7

Top fitness defect scores for YDR029W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_46 0329-0187a 6.61 2.2 µM 1.06E-13 24 1.89E-11
2 SGTC_874 0599-0792 6.18 117.0 µM 3.56E-12 6 3.29E-10
3 SGTC_2625 euphol 4.93 100.0 µM 2.23E-8 15 4.07E-7
4 SGTC_2955 9076254 4.18 12.2 µM 1.76E-6 12 1.44E-5
5 SGTC_875 0709-0210 4.13 25.7 µM 2.30E-6 fatty acid desaturase (OLE1) 28 1.80E-5
6 SGTC_1203 3992-3522 3.83 103.0 µM 1.06E-5 41 6.28E-5
7 SGTC_3040 9091894 3.68 49.5 µM 2.31E-5 DNA intercalators 22 1.18E-4
8 SGTC_1347 1493-0251 3.56 600.0 nM 3.99E-5 mitochondrial response to ROS 23 1.85E-4
9 SGTC_1209 2323-2347 3.51 50.3 µM 5.00E-5 23 2.23E-4
10 SGTC_2490 carminic acid 3.50 95.4 µM 5.33E-5 10 2.35E-4
11 SGTC_2256 7954252 3.36 200.0 µM 9.66E-5 mitochondrial processes 15 3.84E-4
12 SGTC_424 splitomicin 3.32 100.0 mM 1.18E-4 44 4.53E-4
13 SGTC_2586 curcumin 3.30 80.0 µM 1.26E-4 iron homeostasis 88 4.78E-4
14 SGTC_1348 1493-0373 3.24 93.8 µM 1.67E-4 33 6.01E-4
15 SGTC_1214 0358-0031 3.22 63.7 µM 1.78E-4 42 6.34E-4
16 SGTC_1213 1315-0166 3.17 115.0 µM 2.23E-4 59 7.63E-4
17 SGTC_2347 9049783 3.10 174.8 µM 2.98E-4 68 9.68E-4
18 SGTC_427 1354-0053 2.99 47.3 µM 4.62E-4 65 0.00139
19 SGTC_1619 st003326 2.96 88.7 µM 5.33E-4 60S ribosome export 53 0.00156
20 SGTC_239 5hr heat shock (37°C) + mitomycin C 2.91 819.4 µM 6.39E-4 heat shock/prefoldin 79 0.00182

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 9.78E-17 YJL109C UTP10 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance
0.124 8.17E-13 YGR044C RME1 hom Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.120 3.42E-12 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.120 4.23E-12 YLR112W_d YLR112W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.118 7.29E-12 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.114 3.82E-11 YPL116W HOS3 hom Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
0.108 3.69E-10 YBR104W YMC2 hom Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication
0.106 8.55E-10 YBL043W ECM13 hom Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.104 2.04E-9 YMR006C PLB2 hom Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
0.104 2.07E-9 YIL032C_d YIL032C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.103 2.38E-9 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
0.102 3.00E-9 YDR265W PEX10 hom Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders
0.102 3.13E-9 YML076C WAR1 hom Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
0.102 3.32E-9 YJR018W_d YJR018W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.102 3.91E-9 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene