YDR031W / MIC14

Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR031W / MIC14

Click on Significant Values for Screen Details ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.74|P-value:1.74E-7 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.32|P-value:1.88E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-4.97|P-value:5.19E-8 ID:SGTC_520|Compound:3584-0023|FD-Score:-4.07|P-value:6.59E-6 ID:SGTC_521|Compound:r062-0005|FD-Score:-5.32|P-value:6.03E-9 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.24|P-value:2.63E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.34|P-value:1.63E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-2.92|P-value:8.87E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-3.73|P-value:3.33E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:2.97|P-value:6.77E-4 ID:SGTC_1115|Compound:galangin|FD-Score:2.93|P-value:8.04E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-4.81|P-value:1.26E-7 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.21|P-value:2.79E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.11|P-value:4.00E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.04|P-value:5.31E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-2.95|P-value:7.90E-4 ID:SGTC_1846|Compound:st056244|FD-Score:-2.93|P-value:8.60E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.44|P-value:1.05E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-2.90|P-value:9.75E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.86|P-value:1.77E-5 ID:SGTC_2313|Compound:7726885|FD-Score:3.27|P-value:2.14E-4 ID:SGTC_2315|Compound:7733312|FD-Score:2.97|P-value:6.89E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-3.63|P-value:5.02E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.66|P-value:4.55E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-3.71|P-value:3.62E-5 ID:SGTC_2429|Compound:5902844|FD-Score:-3.09|P-value:4.81E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.43|P-value:9.54E-7 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.20|P-value:2.89E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:2.87|P-value:9.88E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.11|P-value:4.08E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.65|P-value:4.19E-5 ID:SGTC_2978|Compound:9011784|FD-Score:-3.03|P-value:5.96E-4 ID:SGTC_2982|Compound:9019404|FD-Score:2.88|P-value:9.64E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-3.32|P-value:1.88E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.61|P-value:5.08E-5 ID:SGTC_3038|Compound:9091290|FD-Score:3.84|P-value:1.81E-5 ID:SGTC_3040|Compound:9091894|FD-Score:-3.02|P-value:6.27E-4 ID:SGTC_3147|Compound:9097027|FD-Score:-3.90|P-value:1.49E-5 ID:SGTC_3153|Compound:9100258|FD-Score:4.80|P-value:1.25E-7 ID:SGTC_3215|Compound:9129942|FD-Score:-4.26|P-value:2.57E-6 ID:SGTC_3248|Compound:9135562|FD-Score:3.49|P-value:8.58E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.74|P-value:1.74E-7 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.32|P-value:1.88E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-4.97|P-value:5.19E-8 ID:SGTC_520|Compound:3584-0023|FD-Score:-4.07|P-value:6.59E-6 ID:SGTC_521|Compound:r062-0005|FD-Score:-5.32|P-value:6.03E-9 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.24|P-value:2.63E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.34|P-value:1.63E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-2.92|P-value:8.87E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-3.73|P-value:3.33E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:2.97|P-value:6.77E-4 ID:SGTC_1115|Compound:galangin|FD-Score:2.93|P-value:8.04E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-4.81|P-value:1.26E-7 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.21|P-value:2.79E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.11|P-value:4.00E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.04|P-value:5.31E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-2.95|P-value:7.90E-4 ID:SGTC_1846|Compound:st056244|FD-Score:-2.93|P-value:8.60E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.44|P-value:1.05E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-2.90|P-value:9.75E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.86|P-value:1.77E-5 ID:SGTC_2313|Compound:7726885|FD-Score:3.27|P-value:2.14E-4 ID:SGTC_2315|Compound:7733312|FD-Score:2.97|P-value:6.89E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-3.63|P-value:5.02E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.66|P-value:4.55E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-3.71|P-value:3.62E-5 ID:SGTC_2429|Compound:5902844|FD-Score:-3.09|P-value:4.81E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.43|P-value:9.54E-7 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.20|P-value:2.89E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:2.87|P-value:9.88E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.11|P-value:4.08E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.65|P-value:4.19E-5 ID:SGTC_2978|Compound:9011784|FD-Score:-3.03|P-value:5.96E-4 ID:SGTC_2982|Compound:9019404|FD-Score:2.88|P-value:9.64E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-3.32|P-value:1.88E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.61|P-value:5.08E-5 ID:SGTC_3038|Compound:9091290|FD-Score:3.84|P-value:1.81E-5 ID:SGTC_3040|Compound:9091894|FD-Score:-3.02|P-value:6.27E-4 ID:SGTC_3147|Compound:9097027|FD-Score:-3.90|P-value:1.49E-5 ID:SGTC_3153|Compound:9100258|FD-Score:4.80|P-value:1.25E-7 ID:SGTC_3215|Compound:9129942|FD-Score:-4.26|P-value:2.57E-6 ID:SGTC_3248|Compound:9135562|FD-Score:3.49|P-value:8.58E-5

Top fitness defect scores for YDR031W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3153 9100258 4.80 49.5 µM 1.25E-7 7 8.13E-7
2 SGTC_102 gallobenzophenone 4.74 83.6 µM 1.74E-7 redox potentiating 28 1.09E-6
3 SGTC_2588 indole-3-carbinol 4.43 100.0 µM 9.54E-7 27 4.78E-6
4 SGTC_3038 9091290 3.84 49.5 µM 1.81E-5 17 6.20E-5
5 SGTC_2874 9043904 3.65 71.4 µM 4.19E-5 19 1.29E-4
6 SGTC_3031 9088762 3.61 49.5 µM 5.08E-5 32 1.53E-4
7 SGTC_3248 9135562 3.49 49.5 µM 8.58E-5 14 2.41E-4
8 SGTC_1879 gemcitabine 3.44 100.0 µM 1.05E-4 29 2.88E-4
9 SGTC_842 0271-0008 3.34 11.1 µM 1.63E-4 heme biosynthesis & mitochondrial translocase 37 4.22E-4
10 SGTC_2313 7726885 3.27 200.0 µM 2.14E-4 RPP1 & pyrimidine depletion 58 5.36E-4
11 SGTC_1237 0330-0133 3.21 46.1 µM 2.79E-4 ergosterol biosynthesis 45 6.75E-4
12 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.20 70.0 µM 2.89E-4 redox potentiating 118 6.96E-4
13 SGTC_1242 0402-0103 3.11 60.1 µM 4.00E-4 60 9.25E-4
14 SGTC_2837 9008476 3.11 45.5 µM 4.08E-4 72 9.42E-4
15 SGTC_1464 k208-0027 3.04 110.0 µM 5.31E-4 52 0.00118
16 SGTC_1106 tegaserod maleate 2.97 11.7 µM 6.77E-4 78 0.00147
17 SGTC_2315 7733312 2.97 200.0 µM 6.89E-4 63 0.00149
18 SGTC_1115 galangin 2.93 695.7 nM 8.04E-4 RPP1 & pyrimidine depletion 62 0.00170
19 SGTC_2982 9019404 2.88 26.0 µM 9.64E-4 72 0.00200
20 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 2.87 100.0 µM 9.88E-4 66 0.00204

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.188 5.08E-28 YDL241W_p YDL241W_p hom Putative protein of unknown function; YDL241W is not an essential gene
0.166 4.78E-22 YBR151W APD1 hom Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
0.133 1.21E-14 YLR072W_p YLR072W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene
0.126 2.27E-13 YLR082C SRL2 hom Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation
0.125 3.72E-13 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.105 1.16E-9 YDR285W ZIP1 hom Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate
0.100 7.22E-9 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.099 9.92E-9 YMR184W ADD37 hom Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress
0.098 1.45E-8 YML059C NTE1 hom Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes
0.097 2.04E-8 YLR124W_d YLR124W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.096 2.40E-8 YDR030C RAD28 hom Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair
0.087 3.90E-7 YIL089W YIL089W hom Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking
0.086 6.20E-7 YJL130C URA2 hom Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
0.085 8.31E-7 YLR014C PPR1 hom Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p
0.084 1.04E-6 YKL097C_d YKL097C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species